SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ar2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A  30
LEU A 127
GLN A  70
ILE A  80
LEU A  85
 None
 1.11A 1drfA-6ar2A:
undetectable		 1drfA-6ar2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A  30
LEU A 127
GLN A  70
ILE A  80
LEU A  85
 None
 1.09A 2w3mA-6ar2A:
undetectable		 2w3mA-6ar2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A   6
PHE A  17
CYH A  48
LEU A  51
HIS A  55
 None
 1.30A 3b0wA-6ar2A:
undetectable		 3b0wA-6ar2A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A  30
LEU A 127
GLN A  70
ILE A  80
LEU A  85
 None
 1.09A 4kebB-6ar2A:
undetectable		 4kebB-6ar2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  44
VAL A  22
LEU A  24
PHE A   8
ILE A  97
 None
 1.25A 4pd5A-6ar2A:
undetectable		 4pd5A-6ar2A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  44
VAL A  22
LEU A  24
PHE A   8
ILE A  97
 None
 1.26A 4pd9A-6ar2A:
undetectable		 4pd9A-6ar2A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN
(Homo
sapiens) 		3 / 3 GLY A  31
LEU A  51
HIS A  55
 None
 0.70A 5u63A-6ar2A:
undetectable		 5u63A-6ar2A:
undetectable