SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ar3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 165
ALA A   9
VAL A 159
LEU A  95
HIS A  49
 None
 1.40A 1aqbA-6ar3A:
undetectable		 1aqbA-6ar3A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 116
HIS A 117
VAL A 120
 None
 0.29A 1lqtB-6ar3A:
undetectable		 1lqtB-6ar3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 116
HIS A 117
VAL A 120
 None
 0.31A 1lquB-6ar3A:
undetectable		 1lquB-6ar3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A 108
TYR A 126
TYR A 228
 None
 0.99A 1x70B-6ar3A:
undetectable		 1x70B-6ar3A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A  63
ASP A  30
ARG A  85
ALA A  26
 U  C   2 ( 2.9A)
None
G  C   4 ( 3.6A)
U  C   3 ( 3.2A)
 1.40A 2rk8A-6ar3A:
undetectable		 2rk8A-6ar3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 195
VAL A 164
ILE A  87
LEU A  52
ILE A   7
 None
 1.26A 3jw3B-6ar3A:
undetectable		 3jw3B-6ar3A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		5 / 9 ARG A 360
ILE A 361
LEU A 369
THR A 390
LEU A 352
 None
 1.41A 3nxuB-6ar3A:
undetectable		 3nxuB-6ar3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A  60
GLY A  31
GLY A  28
ASP A  35
TYR A  40
 None
 1.09A 3o7wA-6ar3A:
undetectable		 3o7wA-6ar3A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 313
SER A 307
GLU A 310
 None
 0.82A 3s8pA-6ar3A:
undetectable		 3s8pA-6ar3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		4 / 4 ASN A  12
SER A 196
LEU A 195
THR A  15
 None
 1.35A 4an2A-6ar3A:
1.9		 4an2A-6ar3A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 211
LEU A 207
LEU A 250
ARG A 214
ILE A 227
 None
 1.07A 4mk4A-6ar3A:
undetectable		 4mk4A-6ar3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A 261
GLN A 236
LEU A 232
SER A 231
 None
 0.86A 4zphA-6ar3A:
undetectable
4zphB-6ar3A:
undetectable		 4zphA-6ar3A:
21.71
4zphB-6ar3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 325
GLY A 271
SER A 288
LEU A 284
 None
 1.10A 5bphB-6ar3A:
undetectable		 5bphB-6ar3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		4 / 6 LYS A  69
ARG A  75
ASP A 138
ASP A 223
 DTP  A 501 (-2.9A)
DTP  A 501 (-4.0A)
MG  A 502 ( 2.8A)
MG  A 502 ( 2.9A)
 1.08A 5hp1A-6ar3A:
9.6		 5hp1A-6ar3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		5 / 6 LYS A  69
ARG A  75
ASP A 138
ASP A 223
LYS A 258
 DTP  A 501 (-2.9A)
DTP  A 501 (-4.0A)
MG  A 502 ( 2.8A)
MG  A 502 ( 2.9A)
DTP  A 501 (-2.8A)
 1.24A 5hp1C-6ar3A:
7.6		 5hp1C-6ar3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A  79
VAL A  62
ARG A  64
GLN A 191
 U  C   3 ( 4.0A)
None
None
DTP  A 501 (-4.1A)
 1.03A 5kkzC-6ar3A:
undetectable
5kkzE-6ar3A:
undetectable		 5kkzC-6ar3A:
18.52
5kkzE-6ar3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A  79
VAL A  62
ARG A  64
GLN A 191
 U  C   3 ( 4.0A)
None
None
DTP  A 501 (-4.1A)
 1.05A 5kkzK-6ar3A:
undetectable
5kkzQ-6ar3A:
undetectable		 5kkzK-6ar3A:
21.38
5kkzQ-6ar3A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 165
VAL A 155
SER A 196
LEU A 198
ILE A 202
 None
 1.36A 6fdyU-6ar3A:
undetectable		 6fdyU-6ar3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 6ar3 GSI-IIC RT
(Geobacillus
stearothermophil
us) 		4 / 5 ALA A  43
TYR A  40
GLN A  51
ILE A  48
 None
 0.96A 6g9bA-6ar3A:
undetectable
6g9bB-6ar3A:
undetectable		 6g9bA-6ar3A:
13.07
6g9bB-6ar3A:
12.17