SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6arr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 SER A  82
GLU A  81
GLU A  80
 None
 0.54A 1eqbD-6arrA:
undetectable		 1eqbD-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 SER A  82
GLU A  81
GLU A  80
 None
 0.54A 1eqbB-6arrA:
undetectable		 1eqbB-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 364
LEU A 368
ILE A 100
LEU A 398
VAL A   7
 None
 1.21A 1hrkA-6arrA:
undetectable		 1hrkA-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 THR A  83
LEU A  47
VAL A  44
VAL A 113
ALA A  40
 None
 1.11A 1q23H-6arrA:
undetectable
1q23I-6arrA:
undetectable		 1q23H-6arrA:
13.76
1q23I-6arrA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 6 GLU A 224
TYR A 187
PHE A 199
ARG A  14
 CS  A 402 ( 4.4A)
None
None
None
 1.49A 2a3bB-6arrA:
undetectable		 2a3bB-6arrA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 ALA A  29
GLY A 357
ILE A 356
ALA A  63
VAL A  65
 None
 1.00A 2b7zA-6arrA:
undetectable		 2b7zA-6arrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 11 THR A  86
THR A  87
ALA A  70
GLY A 102
ALA A 116
 None
 1.23A 2f16N-6arrA:
undetectable		 2f16N-6arrA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 7 ILE A 352
GLY A 347
LEU A 198
PHE A 199
 None
 0.97A 2vctD-6arrA:
undetectable		 2vctD-6arrA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 ILE A  37
GLN A  31
ASN A  68
VAL A  52
CYH A  85
 None
 0.94A 3dzuA-6arrA:
undetectable		 3dzuA-6arrA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 11 LEU A 306
ALA A 301
GLY A 283
ILE A 302
SER A 391
 None
 1.06A 3gyqB-6arrA:
undetectable		 3gyqB-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 9 ILE A  99
ILE A 100
LEU A 393
LEU A 264
ALA A 116
 None
 1.09A 3ozvB-6arrA:
undetectable		 3ozvB-6arrA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 GLY A  22
ASP A 257
ILE A 206
VAL A 217
VAL A 219
 None
 1.01A 3ucbA-6arrA:
undetectable		 3ucbA-6arrA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 GLY A  22
ASP A 257
ILE A 206
VAL A 217
VAL A 219
 None
 1.02A 3ucbB-6arrA:
undetectable		 3ucbB-6arrA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 ILE A   9
LEU A 364
GLY A 102
ALA A 103
LEU A  96
 None
 1.07A 3vaqB-6arrA:
undetectable		 3vaqB-6arrA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 6 CYH A  85
THR A  86
ASN A  68
ILE A  37
 None
 1.32A 3w9tB-6arrA:
undetectable		 3w9tB-6arrA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 10 ASN A 344
GLU A 323
ASP A 222
GLU A 202
GLY A 360
 None
 1.47A 4evyA-6arrA:
undetectable
4evyB-6arrA:
undetectable		 4evyA-6arrA:
22.86
4evyB-6arrA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 11 GLY A 348
ASN A 344
ALA A 318
PRO A 225
PHE A 199
 None
 1.42A 4j4vA-6arrA:
undetectable		 4j4vA-6arrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 10 GLY A 348
ASN A 344
ALA A 318
PRO A 225
PHE A 199
 None
 1.42A 4j4vB-6arrA:
undetectable		 4j4vB-6arrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 10 GLY A 348
ASN A 344
ALA A 318
PRO A 225
PHE A 199
 None
 1.42A 4j4vA-6arrA:
undetectable
4j4vE-6arrA:
undetectable		 4j4vA-6arrA:
17.34
4j4vE-6arrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 364
LEU A 368
ILE A   9
GLY A 379
LEU A 393
 None
 1.02A 4lmnA-6arrA:
undetectable		 4lmnA-6arrA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 11 THR A 366
GLY A 347
GLY A 348
ALA A 349
SER A 253
 None
 1.04A 4qvlK-6arrA:
undetectable
4qvlL-6arrA:
undetectable		 4qvlK-6arrA:
17.39
4qvlL-6arrA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 11 THR A 366
GLY A 347
GLY A 348
ALA A 349
SER A 253
 None
 1.03A 4qvlY-6arrA:
undetectable
4qvlZ-6arrA:
undetectable		 4qvlY-6arrA:
17.39
4qvlZ-6arrA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 THR A  86
THR A  87
ALA A  70
GLY A 102
ALA A 116
 None
 1.26A 4qvnV-6arrA:
undetectable
4qvnb-6arrA:
undetectable		 4qvnV-6arrA:
16.23
4qvnb-6arrA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 THR A  86
THR A  87
ALA A  70
GLY A 102
ALA A 116
 None
 1.26A 4qvnH-6arrA:
undetectable
4qvnN-6arrA:
undetectable		 4qvnH-6arrA:
16.23
4qvnN-6arrA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 6 PRO A 225
GLY A 348
PHE A 199
ARG A  14
 None
 1.39A 5jcnB-6arrA:
undetectable		 5jcnB-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 10 ALA A 183
GLU A 188
ALA A 349
GLY A 348
ALA A 351
 None
 1.22A 5lf3V-6arrA:
undetectable
5lf3W-6arrA:
undetectable		 5lf3V-6arrA:
21.58
5lf3W-6arrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 VAL A  88
LEU A  96
ALA A  98
THR A 365
GLY A  33
 None
 1.16A 5m5cB-6arrA:
undetectable		 5m5cB-6arrA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 10 VAL A  88
LEU A  96
ALA A  98
THR A 365
GLY A  33
 None
 1.14A 5m5cE-6arrA:
undetectable		 5m5cE-6arrA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 10 GLY A 118
GLY A 357
LEU A 393
ILE A 363
LEU A 364
 None
 1.08A 5vm8B-6arrA:
undetectable		 5vm8B-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 GLY A  58
THR A 119
GLU A 120
 None
 0.63A 6b58A-6arrA:
undetectable		 6b58A-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 11 ASP A 222
VAL A  17
THR A  15
VAL A 350
ALA A 259
 None
None
None
CS  A 402 (-4.6A)
None
 1.13A 6dryA-6arrA:
undetectable		 6dryA-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 THR A  86
THR A  87
ALA A  70
GLY A 102
ALA A 116
 None
 1.24A 6hwdV-6arrA:
undetectable
6hwdb-6arrA:
undetectable		 6hwdV-6arrA:
21.95
6hwdb-6arrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		5 / 12 THR A  86
THR A  87
ALA A  70
GLY A 102
ALA A 116
 None
 1.24A 6hwdH-6arrA:
undetectable
6hwdN-6arrA:
undetectable		 6hwdH-6arrA:
21.95
6hwdN-6arrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 ASN A 332
PRO A 298
GLN A 289
 None
 0.90A 6jnhA-6arrA:
undetectable		 6jnhA-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 ASN A 332
PRO A 298
GLN A 289
 None
 0.88A 6jogA-6arrA:
undetectable		 6jogA-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6arr ACETYL-COA
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 7 ASP A 222
ARG A 362
GLU A 202
GLU A 320
 None
 1.18A 6mn5E-6arrA:
undetectable		 6mn5E-6arrA:
26.37