SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6arx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 9 TRP A 245
GLY A 278
TRP A 592
HIS A 600
GLY A 601
 None
 0.99A 1acjA-6arxA:
65.3		 1acjA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 9 TRP A 245
GLY A 279
GLU A 359
TYR A 493
TRP A 592
HIS A 600
GLY A 601
 None
 0.44A 1acjA-6arxA:
65.3		 1acjA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACL_A_DMEA999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 10 TRP A 245
TYR A 282
GLU A 359
SER A 360
TRP A 441
TYR A 493
HIS A 600
GLY A 601
 None
 0.45A 1aclA-6arxA:
64.0		 1aclA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 TRP A 245
GLY A 278
PHE A 490
HIS A 600
 None
 0.99A 1ax9A-6arxA:
59.3		 1ax9A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 8 TRP A 245
GLY A 279
TYR A 282
GLU A 359
PHE A 490
HIS A 600
 None
 0.45A 1ax9A-6arxA:
59.3		 1ax9A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 8 TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
HIS A 600
 None
 0.67A 1ax9A-6arxA:
59.3		 1ax9A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 ASP A 233
GLY A 279
TYR A 282
SER A 360
PHE A 490
HIS A 600
 None
 1.12A 1dx6A-6arxA:
65.4		 1dx6A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 ASP A 233
TRP A 245
GLY A 278
GLY A 279
TYR A 282
SER A 360
TRP A 393
PHE A 449
PHE A 490
HIS A 600
 None
 0.36A 1dx6A-6arxA:
65.4		 1dx6A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 GLY A 362
SER A 360
TRP A 393
PHE A 449
PHE A 490
HIS A 600
 None
 1.22A 1dx6A-6arxA:
65.4		 1dx6A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		9 / 10 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TRP A 441
LEU A 444
PHE A 490
TYR A 493
HIS A 600
 None
 0.78A 1eveA-6arxA:
64.4		 1eveA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 LEU A 368
LEU A 371
SER A 367
HIS A 600
PHE A 449
 None
 1.27A 1fmlA-6arxA:
undetectable		 1fmlA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 GLY A 358
ALA A 382
HIS A 369
LEU A 371
TYR A 309
 None
 1.27A 1kiaD-6arxA:
undetectable		 1kiaD-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 GLY A 358
ALA A 382
SER A 365
HIS A 369
LEU A 371
 None
 1.30A 1kiaD-6arxA:
undetectable		 1kiaD-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		11 / 12 ASP A 233
TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
TRP A 441
PHE A 449
TYR A 489
TYR A 493
HIS A 600
 None
 0.64A 1maaA-6arxA:
55.1		 1maaA-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 TRP A 245
GLY A 278
SER A 360
TYR A 489
HIS A 600
 None
 1.07A 1maaA-6arxA:
55.1		 1maaA-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 TRP A 245
TYR A 282
GLU A 359
ILE A 446
 None
 0.74A 1maaB-6arxA:
64.4
1maaD-6arxA:
55.1		 1maaB-6arxA:
9.77
1maaD-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 TRP A 245
TYR A 282
GLU A 359
TYR A 493
 None
 0.56A 1maaB-6arxA:
64.4
1maaD-6arxA:
55.1		 1maaB-6arxA:
9.77
1maaD-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 TRP A 245
GLY A 278
SER A 360
TYR A 489
PHE A 490
HIS A 600
 None
 1.01A 1maaC-6arxA:
57.4		 1maaC-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 TRP A 245
GLY A 279
TYR A 282
TYR A 291
SER A 360
PHE A 449
TYR A 489
PHE A 490
TYR A 493
HIS A 600
 None
 0.71A 1maaC-6arxA:
57.4		 1maaC-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 TRP A 245
GLY A 279
TYR A 282
TYR A 291
SER A 360
TRP A 441
PHE A 449
TYR A 489
PHE A 490
HIS A 600
 None
 0.54A 1maaC-6arxA:
57.4		 1maaC-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 TRP A 245
GLY A 278
SER A 360
HIS A 600
 None
 1.03A 1maaD-6arxA:
55.1		 1maaD-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 8 TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
TRP A 441
TYR A 493
HIS A 600
 None
 0.60A 1maaD-6arxA:
55.1		 1maaD-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 ASP A 233
GLY A 279
TYR A 282
SER A 360
PHE A 490
HIS A 600
 None
 1.10A 1qtiA-6arxA:
59.1		 1qtiA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 ASP A 233
TRP A 245
GLY A 278
GLY A 279
TYR A 282
GLU A 359
SER A 360
PHE A 449
PHE A 490
HIS A 600
 None
 0.37A 1qtiA-6arxA:
59.1		 1qtiA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 12 GLY A 278
GLY A 279
GLU A 359
SER A 360
PHE A 490
PHE A 449
HIS A 600
 None
 1.03A 1qtiA-6arxA:
59.1		 1qtiA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 GLY A 362
GLU A 359
SER A 360
PHE A 449
PHE A 490
HIS A 600
 None
 1.29A 1qtiA-6arxA:
59.1		 1qtiA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 GLY A 362
GLU A 359
SER A 360
PHE A 490
PHE A 449
HIS A 600
 None
 1.26A 1qtiA-6arxA:
59.1		 1qtiA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 11 TRP A 245
TYR A 282
GLU A 359
TRP A 441
LEU A 444
HIS A 600
 None
 0.90A 1u65A-6arxA:
58.6		 1u65A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 11 TRP A 245
TYR A 282
GLU A 359
TRP A 441
TYR A 493
HIS A 600
 None
 0.51A 1u65A-6arxA:
58.6		 1u65A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 ASP A 233
GLY A 279
TYR A 282
SER A 360
PHE A 490
HIS A 600
 None
 1.10A 1w6rA-6arxA:
65.5		 1w6rA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		9 / 12 ASP A 233
TRP A 245
GLY A 278
GLY A 279
TYR A 282
SER A 360
PHE A 449
PHE A 490
HIS A 600
 None
 0.38A 1w6rA-6arxA:
65.5		 1w6rA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 12 GLY A 278
GLY A 279
TYR A 282
SER A 360
PHE A 490
PHE A 449
HIS A 600
 None
 1.05A 1w6rA-6arxA:
65.5		 1w6rA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 ASP A 233
GLY A 279
TYR A 282
GLU A 359
SER A 360
PHE A 490
HIS A 600
 None
 1.11A 1w76A-6arxA:
61.2		 1w76A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		9 / 11 ASP A 233
TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
PHE A 449
PHE A 490
HIS A 600
 None
 0.40A 1w76A-6arxA:
61.2		 1w76A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 GLY A 278
GLY A 279
SER A 360
PHE A 490
HIS A 600
 None
 1.36A 1w76A-6arxA:
61.2		 1w76A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 TRP A 245
GLY A 278
SER A 360
PHE A 490
HIS A 600
 None
 1.18A 1w76A-6arxA:
61.2		 1w76A-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 10 ASP A 233
TRP A 245
GLY A 278
GLY A 279
TYR A 282
GLU A 359
SER A 360
PHE A 449
PHE A 490
HIS A 600
 None
 0.38A 1w76B-6arxA:
61.0		 1w76B-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 10 GLY A 362
GLU A 359
SER A 360
PHE A 449
PHE A 490
HIS A 600
 None
 1.31A 1w76B-6arxA:
61.0		 1w76B-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 9 GLY A 278
GLY A 279
SER A 360
ALA A 361
PHE A 490
HIS A 600
 None
 1.03A 2aceA-6arxA:
64.3		 2aceA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 9 GLY A 279
SER A 360
ALA A 361
PHE A 490
PHE A 449
HIS A 600
 None
 1.16A 2aceA-6arxA:
64.3		 2aceA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 9 GLY A 279
SER A 360
ALA A 361
TRP A 393
PHE A 449
HIS A 600
 None
 0.34A 2aceA-6arxA:
64.3		 2aceA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 7 TRP A 245
GLY A 278
GLU A 359
SER A 360
HIS A 600
 None
 1.33A 2ackA-6arxA:
64.8		 2ackA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 7 TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
PHE A 490
HIS A 600
 None
 0.68A 2ackA-6arxA:
64.8		 2ackA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 TYR A 535
LEU A 690
TYR A 558
HIS A 559
ILE A 446
 None
 1.01A 2efjA-6arxA:
undetectable		 2efjA-6arxA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 8 ASP A 233
TRP A 245
TYR A 282
TRP A 441
TYR A 489
TYR A 493
HIS A 600
 None
 0.81A 2ha2A-6arxA:
56.9		 2ha2A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 8 ASP A 233
TRP A 245
TYR A 282
TRP A 441
TYR A 489
TYR A 493
HIS A 600
 None
 0.89A 2ha2B-6arxA:
64.4		 2ha2B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 8 TRP A 245
TYR A 282
TYR A 291
GLU A 359
TYR A 489
PHE A 490
HIS A 600
GLY A 601
 None
 0.43A 2ha4A-6arxA:
57.2		 2ha4A-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 7 TRP A 245
TYR A 282
TYR A 291
GLU A 359
TYR A 489
HIS A 600
GLY A 601
 None
 0.46A 2ha4B-6arxA:
64.7		 2ha4B-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 7 GLY A 279
ALA A 361
TRP A 393
PHE A 449
HIS A 600
 None
 0.38A 2ha4B-6arxA:
64.7		 2ha4B-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 9 ASP A 233
TRP A 245
TYR A 282
GLU A 359
TRP A 441
TYR A 489
TYR A 493
 None
 0.81A 2ha6A-6arxA:
57.2		 2ha6A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 9 ASP A 233
TYR A 282
ALA A 361
TRP A 441
TYR A 489
 None
 1.28A 2ha6A-6arxA:
57.2		 2ha6A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 10 MET A 244
ASN A 246
ASP A 289
LEU A 616
TYR A 618
 None
 0.60A 2ha6A-6arxA:
57.2		 2ha6A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 10 MET A 244
ASN A 246
GLU A 610
LEU A 616
TYR A 618
 None
 1.28A 2ha6A-6arxA:
57.2		 2ha6A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 9 TRP A 245
TYR A 282
TRP A 441
TYR A 489
PHE A 490
TYR A 493
HIS A 600
GLY A 601
 None
 0.80A 2ha6B-6arxA:
64.4		 2ha6B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 10 MET A 244
ASN A 246
ASP A 289
LEU A 616
TYR A 618
 None
 0.69A 2ha6B-6arxA:
64.4		 2ha6B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 GLU A 253
LEU A 317
GLY A 430
VAL A 412
ALA A 409
 None
 0.97A 2kceA-6arxA:
undetectable		 2kceA-6arxA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 THR A 249
SER A 227
ALA A 286
PRO A 224
 None
 1.16A 2v41G-6arxA:
undetectable
2v41H-6arxA:
undetectable		 2v41G-6arxA:
undetectable
2v41H-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XUD_A_DMEA1544_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 6 TRP A 245
TYR A 282
TRP A 441
TYR A 493
HIS A 600
 None
 0.65A 2xudA-6arxA:
55.4		 2xudA-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 THR A 561
PHE A 560
PHE A 490
GLU A 486
GLU A 603
 None
 1.34A 3apxA-6arxA:
undetectable		 3apxA-6arxA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 TYR A 309
GLU A 359
ASP A 602
 None
 0.82A 3bxoA-6arxA:
undetectable		 3bxoA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 VAL A 564
TYR A 581
GLY A 362
ALA A 363
LEU A 370
 None
 0.96A 3hs6A-6arxA:
undetectable		 3hs6A-6arxA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 ILE A 276
SER A 360
GLY A 362
SER A 280
LEU A 307
 None
 1.37A 3iluB-6arxA:
undetectable
3iluE-6arxA:
undetectable		 3iluB-6arxA:
17.24
3iluE-6arxA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 7 GLY A 279
SER A 360
TRP A 393
PHE A 560
HIS A 600
 None
 0.30A 3o9mA-6arxA:
64.2		 3o9mA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 GLY A 279
SER A 360
TRP A 393
HIS A 600
 None
 0.37A 3o9mB-6arxA:
64.3		 3o9mB-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 TYR A 583
GLY A 481
SER A 482
LEU A 479
TRP A 633
 None
 1.42A 3ou6D-6arxA:
undetectable		 3ou6D-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 ILE A 258
TYR A 196
ALA A 286
LEU A 337
ALA A 382
 None
 1.22A 3ozuA-6arxA:
undetectable		 3ozuA-6arxA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 5 SER A 227
GLY A 278
GLU A 603
GLU A 359
 None
 1.49A 3raeB-6arxA:
undetectable
3raeD-6arxA:
3.0		 3raeB-6arxA:
11.11
3raeD-6arxA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 GLY A 279
SER A 280
PHE A 281
ALA A 394
SER A 367
 None
 1.21A 3sueD-6arxA:
undetectable		 3sueD-6arxA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 THR A 390
ASN A 563
GLY A 387
ILE A 478
 None
 0.96A 3w9tF-6arxA:
undetectable		 3w9tF-6arxA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 7 GLU A 400
GLU A 448
TYR A 522
VAL A 694
 None
 1.03A 4a97A-6arxA:
undetectable		 4a97A-6arxA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 7 GLU A 400
GLU A 448
TYR A 522
VAL A 694
 None
 1.04A 4a97D-6arxA:
undetectable		 4a97D-6arxA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 7 GLU A 400
GLU A 448
TYR A 522
VAL A 694
 None
 1.04A 4a97H-6arxA:
undetectable		 4a97H-6arxA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BDS_A_THAA701_1
(CHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 9 TRP A 245
GLU A 359
SER A 360
TYR A 493
TRP A 592
MET A 599
HIS A 600
GLY A 601
 None
 0.69A 4bdsA-6arxA:
61.9		 4bdsA-6arxA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 PHE A 379
TYR A 581
GLY A 362
ALA A 363
LEU A 370
 None
 0.92A 4e1gA-6arxA:
0.0		 4e1gA-6arxA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 PHE A 379
TYR A 581
GLY A 362
ALA A 363
LEU A 370
 None
 0.91A 4e1gB-6arxA:
undetectable		 4e1gB-6arxA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 GLY A 278
GLY A 279
SER A 360
PHE A 490
PHE A 449
HIS A 600
 None
 1.17A 4ey6A-6arxA:
65.0		 4ey6A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 12 GLY A 279
TYR A 282
SER A 283
SER A 360
TYR A 489
PHE A 490
HIS A 600
 None
 1.16A 4ey6A-6arxA:
65.0		 4ey6A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 TRP A 245
GLY A 278
GLY A 279
TYR A 282
SER A 283
SER A 360
PHE A 449
TYR A 489
PHE A 490
HIS A 600
 None
 0.47A 4ey6A-6arxA:
65.0		 4ey6A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 TRP A 245
GLY A 278
TYR A 489
PHE A 490
HIS A 600
 None
 0.89A 4ey6A-6arxA:
65.0		 4ey6A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 12 GLY A 278
GLY A 279
GLU A 359
SER A 360
PHE A 490
PHE A 449
HIS A 600
 None
 1.11A 4ey6B-6arxA:
55.7		 4ey6B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 12 GLY A 279
TYR A 282
GLU A 359
SER A 360
TYR A 489
PHE A 490
HIS A 600
 None
 1.10A 4ey6B-6arxA:
55.7		 4ey6B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 TRP A 245
GLY A 278
GLY A 279
PHE A 560
TYR A 489
HIS A 600
 None
 1.33A 4ey6B-6arxA:
55.7		 4ey6B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 TRP A 245
GLY A 278
GLY A 279
TYR A 282
GLU A 359
SER A 360
PHE A 449
TYR A 489
PHE A 490
HIS A 600
 None
 0.47A 4ey6B-6arxA:
55.7		 4ey6B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 TRP A 245
GLY A 278
TYR A 489
PHE A 490
HIS A 600
 None
 0.91A 4ey6B-6arxA:
55.7		 4ey6B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLU A 359
SER A 360
TRP A 441
TYR A 489
HIS A 600
GLY A 601
 None
 0.96A 4ey7A-6arxA:
64.9		 4ey7A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLU A 359
SER A 360
TYR A 489
TYR A 493
HIS A 600
GLY A 601
 None
 1.12A 4ey7A-6arxA:
64.9		 4ey7A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 11 TRP A 245
GLY A 278
SER A 360
TYR A 489
HIS A 600
GLY A 601
 None
 1.29A 4ey7A-6arxA:
64.9		 4ey7A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 11 TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
TRP A 441
HIS A 600
GLY A 601
 None
 0.79A 4ey7A-6arxA:
64.9		 4ey7A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 11 TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
TYR A 493
HIS A 600
GLY A 601
 None
 0.69A 4ey7A-6arxA:
64.9		 4ey7A-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLU A 359
SER A 360
TRP A 441
TYR A 489
HIS A 600
GLY A 601
 None
 0.97A 4ey7B-6arxA:
57.1		 4ey7B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLU A 359
SER A 360
TYR A 489
TYR A 493
HIS A 600
GLY A 601
 None
 1.13A 4ey7B-6arxA:
57.1		 4ey7B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 11 TRP A 245
GLY A 278
SER A 360
TYR A 489
HIS A 600
GLY A 601
 None
 1.30A 4ey7B-6arxA:
57.1		 4ey7B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 11 TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
TRP A 441
HIS A 600
GLY A 601
 None
 0.78A 4ey7B-6arxA:
57.1		 4ey7B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 11 TRP A 245
GLY A 279
TYR A 282
GLU A 359
SER A 360
TYR A 493
HIS A 600
GLY A 601
 None
 0.68A 4ey7B-6arxA:
57.1		 4ey7B-6arxA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 ILE A 478
THR A 480
TYR A 581
LEU A 384
VAL A 366
 None
 1.02A 4g1bB-6arxA:
undetectable		 4g1bB-6arxA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 9 ILE A 478
THR A 480
TYR A 581
LEU A 384
VAL A 366
 None
 1.01A 4g1bC-6arxA:
undetectable		 4g1bC-6arxA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 ILE A 478
THR A 480
TYR A 581
LEU A 384
VAL A 366
 None
 1.03A 4g1bD-6arxA:
undetectable		 4g1bD-6arxA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 HIS A 559
GLY A 445
ILE A 446
 None
 0.63A 4k50A-6arxA:
undetectable		 4k50A-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 HIS A 559
GLY A 445
ILE A 446
 None
 0.62A 4k50I-6arxA:
undetectable		 4k50I-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 ALA A 197
GLN A 198
LEU A 256
LEU A 204
 None
 0.93A 4xp3A-6arxA:
undetectable		 4xp3A-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 VAL A 598
GLU A 486
GLY A 487
TYR A 489
ILE A 446
 None
 1.36A 4xudA-6arxA:
2.8		 4xudA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 ASN A 565
ASP A 557
THR A 480
VAL A 564
 None
 0.96A 4yoaA-6arxA:
undetectable		 4yoaA-6arxA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 ILE A 446
LEU A 519
GLY A 487
GLY A 387
PHE A 449
 None
 1.13A 5d4uA-6arxA:
undetectable		 5d4uA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 ASP A 233
TYR A 282
TRP A 441
TYR A 493
 None
 0.60A 5e2iA-6arxA:
64.5		 5e2iA-6arxA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4J_A_DMEA608_1
(ACETYLCHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 9 TRP A 245
TYR A 282
GLU A 359
TRP A 441
TYR A 493
HIS A 600
GLY A 601
 None
 0.60A 5e4jA-6arxA:
64.4		 5e4jA-6arxA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 ASP A 456
ARG A 210
ARG A 310
 None
 0.96A 5eajB-6arxA:
undetectable		 5eajB-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 PHE A 239
GLY A 241
TRP A 245
ASP A 602
 None
 0.90A 5gqbA-6arxA:
undetectable		 5gqbA-6arxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 SER A 280
SER A 283
PHE A 490
 None
 0.85A 5mugA-6arxA:
undetectable		 5mugA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 ASN A 563
GLU A 486
PHE A 560
TYR A 535
 None
 1.42A 5oh1C-6arxA:
undetectable		 5oh1C-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 GLU A 603
TRP A 275
HIS A 600
 None
 0.93A 5xipA-6arxA:
undetectable		 5xipA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 GLY A 362
SER A 306
ALA A 286
PHE A 277
 None
 0.74A 5xu8A-6arxA:
undetectable		 5xu8A-6arxA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 5 TRP A 245
TYR A 291
GLU A 359
TYR A 493
HIS A 600
 None
 0.55A 6ep4A-6arxA:
64.6		 6ep4A-6arxA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 GLY A 279
SER A 360
PHE A 490
TYR A 493
 None
 0.87A 6eqpA-6arxA:
undetectable		 6eqpA-6arxA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 6arx ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 8 TRP A 245
SER A 360
TRP A 393
PHE A 490
TYR A 493
 None
 0.61A 6eqpA-6arxA:
undetectable		 6eqpA-6arxA:
40.00