SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6aso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 240
PHE A 260
LEU A 221
LEU A 217
MET A 272
 None
 1.10A 1dtlA-6asoA:
undetectable		 1dtlA-6asoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 270
ARG A 210
ILE A 237
PHE A 260
 None
 1.32A 3ln1D-6asoA:
undetectable		 3ln1D-6asoA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 393
VAL A 298
ILE A 387
ARG A 153
 None
None
None
C  I  58 ( 4.0A)
 1.05A 3ms9B-6asoA:
undetectable		 3ms9B-6asoA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  61
TYR A  60
PHE A  87
THR A  98
ILE A  97
 None
 1.25A 3ndiA-6asoA:
undetectable		 3ndiA-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 393
VAL A 298
ILE A 387
ARG A 153
 None
None
None
C  I  58 ( 4.0A)
 1.05A 3pyyA-6asoA:
undetectable		 3pyyA-6asoA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 110
VAL A  57
ASN A  47
LEU A  48
PRO A  49
 None
 0.93A 4gc9A-6asoA:
undetectable		 4gc9A-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 6 ASP A  91
ALA A  88
THR A  41
TYR A  90
 None
 1.46A 4w5qA-6asoA:
2.6		 4w5qA-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 6 ASP A  91
ALA A  88
THR A  41
TYR A  90
 None
 1.42A 4z4fA-6asoA:
2.8		 4z4fA-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 5 ASP A  91
ALA A  88
THR A  41
TYR A  90
 None
 1.48A 4z4hA-6asoA:
3.0		 4z4hA-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		4 / 6 ASP A  91
ALA A  88
THR A  41
TYR A  90
 None
 1.43A 4z4iA-6asoA:
2.3		 4z4iA-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  69
VAL A  72
ILE A  97
ALA A  93
VAL A 111
 None
 1.14A 5n0sB-6asoA:
undetectable		 5n0sB-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  69
VAL A  72
ILE A  97
ALA A  93
VAL A 111
 None
 1.13A 5n0xA-6asoA:
undetectable		 5n0xA-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 162
PRO A 150
LEU A 149
 G  I  50 ( 3.4A)
None
None
 0.85A 6beoA-6asoA:
undetectable		 6beoA-6asoA:
undetectable