SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ave'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 4 LYS A 142
LEU A 109
ALA A 143
LEU A 119
 None
 1.33A 1f86B-6aveA:
2.3		 1f86B-6aveA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 7 PHE A 153
ALA A 112
TYR A 159
PRO A 338
 None
 1.11A 1oniA-6aveA:
undetectable
1oniB-6aveA:
undetectable		 1oniA-6aveA:
undetectable
1oniB-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		5 / 12 PHE A 101
GLY A 163
ASP A 228
ILE A 138
PRO A 232
 None
 1.05A 2hmyB-6aveA:
undetectable		 2hmyB-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 4 LYS A 142
LEU A 109
ALA A 143
LEU A 119
 None
 1.40A 2roxA-6aveA:
2.7		 2roxA-6aveA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		5 / 12 PHE A 101
GLY A 163
ASP A 228
ILE A 138
PRO A 232
 None
 0.93A 3eeoA-6aveA:
undetectable		 3eeoA-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		3 / 3 GLU A 278
TYR A 371
SER A 252
 None
 0.84A 4at0A-6aveA:
undetectable		 4at0A-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 4 ILE A 400
SER A 396
ASP A 224
ASP A 165
 None
 1.27A 4krhB-6aveA:
undetectable		 4krhB-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 7 TYR A 301
SER A 298
ALA A 308
SER A 305
 None
 1.22A 4lv9A-6aveA:
undetectable
4lv9B-6aveA:
undetectable		 4lv9A-6aveA:
10.11
4lv9B-6aveA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 5 ARG A 325
THR A 315
ASP A 312
TYR A 301
 None
 1.43A 4oltA-6aveA:
undetectable		 4oltA-6aveA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 5 ARG A 325
THR A 315
ASP A 312
TYR A 301
 None
 1.43A 4oltB-6aveA:
undetectable		 4oltB-6aveA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 5 ARG A 325
THR A 315
ASP A 312
TYR A 301
 None
 1.42A 4qwpA-6aveA:
undetectable		 4qwpA-6aveA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 5 ARG A 325
THR A 315
ASP A 312
TYR A 301
 None
 1.46A 4qwpB-6aveA:
undetectable		 4qwpB-6aveA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 4 LYS A 142
LEU A 109
ALA A 143
LEU A 119
 None
 1.29A 6gnrA-6aveA:
2.5		 6gnrA-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 6ave ACID-SENSING ION
CHANNEL 1
(Gallus
gallus) 		4 / 4 LYS A 142
LEU A 109
ALA A 143
LEU A 119
 None
 1.27A 6gnrB-6aveA:
2.3		 6gnrB-6aveA:
undetectable