SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6avh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		5 / 10 GLU A 508
ALA A 447
LEU A 454
GLU A 502
GLU A 501
 None
 1.43A 1a29A-6avhA:
undetectable		 1a29A-6avhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 7 THR A 557
SER A 560
ARG A 559
LEU A 432
 None
 1.15A 1ibgL-6avhA:
undetectable		 1ibgL-6avhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		5 / 10 TYR A  44
ILE A  74
PRO A  82
GLU A  81
ILE A  77
 None
 1.35A 2dm6A-6avhA:
undetectable
2dm6B-6avhA:
undetectable		 2dm6A-6avhA:
13.31
2dm6B-6avhA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 5 LEU A 401
LEU A 110
CYH A  87
THR A  42
 None
 1.31A 2oaxD-6avhA:
undetectable		 2oaxD-6avhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 445
VAL A 448
THR A 449
ASP A 464
 None
 0.89A 2qblA-6avhA:
undetectable		 2qblA-6avhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 4 GLY A 303
GLU A 441
ASP A 408
TYR A 326
 AMP  A 600 ( 4.2A)
None
AMP  A 600 (-2.8A)
AMP  A 600 (-4.8A)
 1.20A 2yvlC-6avhA:
undetectable		 2yvlC-6avhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		5 / 12 ASP A 443
LEU A 511
SER A 467
ILE A 480
LEU A 528
 None
 1.04A 3k2hB-6avhA:
undetectable		 3k2hB-6avhA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		5 / 10 GLY A 317
GLU A 284
LEU A 287
LEU A 319
ILE A 297
 None
 1.33A 3kvrB-6avhA:
undetectable		 3kvrB-6avhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 4 GLY A 426
GLU A 441
ASP A 443
ASP A 408
 None
None
None
AMP  A 600 (-2.8A)
 1.39A 3mb5A-6avhA:
undetectable		 3mb5A-6avhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		5 / 9 GLY A 317
GLU A 284
LEU A 287
LEU A 319
ILE A 297
 None
 1.32A 3nbqA-6avhA:
undetectable		 3nbqA-6avhA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 4 PHE A 332
TYR A 348
ARG A 405
LEU A 401
 None
AMP  A 600 (-4.0A)
None
None
 1.34A 3sueA-6avhA:
undetectable		 3sueA-6avhA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		5 / 12 PRO A 393
LEU A 410
ILE A 350
PHE A 325
TYR A 125
 None
 1.25A 4a79A-6avhA:
undetectable		 4a79A-6avhA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		5 / 12 PRO A 393
LEU A 410
ILE A 350
PHE A 325
TYR A 125
 None
 1.25A 4a79B-6avhA:
undetectable		 4a79B-6avhA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 8 GLU A 456
GLY A 485
THR A 466
TRP A 482
 None
 0.98A 5flcB-6avhA:
undetectable		 5flcB-6avhA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 8 GLU A 456
GLY A 485
THR A 466
TRP A 482
 None
 0.98A 5flcF-6avhA:
undetectable		 5flcF-6avhA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 4 VAL A 514
GLY A 518
ASP A 522
ASP A 435
 None
 1.38A 6cjkC-6avhA:
undetectable		 6cjkC-6avhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE
(Arabidopsis
thaliana) 		4 / 8 ASP A 443
GLY A 476
SER A 473
VAL A 479
 None
 1.06A 6giqL-6avhA:
undetectable
6giqP-6avhA:
undetectable
6giqT-6avhA:
undetectable		 6giqL-6avhA:
undetectable
6giqP-6avhA:
undetectable
6giqT-6avhA:
undetectable