SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6avy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		5 / 11 PRO A 165
LEU A 133
VAL A 122
GLY A 123
TRP A 163
 None
 1.43A 1fkpA-6avyA:
undetectable		 1fkpA-6avyA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		4 / 7 SER A 161
ASP A 197
GLU A 236
GLU A 235
 None
 1.19A 1knyA-6avyA:
undetectable
1knyB-6avyA:
undetectable		 1knyA-6avyA:
15.14
1knyB-6avyA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		5 / 11 ASN A 153
VAL A 152
TYR A 144
ALA A 104
SER A 135
 None
 1.35A 2iyfA-6avyA:
4.6		 2iyfA-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		6 / 12 ASN A 153
VAL A 152
TYR A 144
LEU A 189
ALA A 104
SER A 135
 None
 1.41A 2iyfB-6avyA:
3.5		 2iyfB-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		5 / 10 ILE A  60
ILE A  35
VAL A 122
GLY A 124
LEU A  55
 None
 1.27A 3em0A-6avyA:
undetectable		 3em0A-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		5 / 12 GLY A 128
ALA A 136
LEU A 160
TRP A 163
LEU A 133
 None
 1.00A 3p2kA-6avyA:
2.3		 3p2kA-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		5 / 12 GLY A 128
ALA A 136
LEU A 160
TRP A 163
LEU A 133
 None
 1.12A 3p2kB-6avyA:
2.3		 3p2kB-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		5 / 12 GLY A 128
ALA A 136
LEU A 160
TRP A 163
LEU A 133
 None
 1.07A 3p2kD-6avyA:
undetectable		 3p2kD-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		4 / 6 LEU A 244
LEU A 221
PRO A 188
LEU A 190
 None
 0.95A 3q1eA-6avyA:
undetectable
3q1eC-6avyA:
undetectable		 3q1eA-6avyA:
24.37
3q1eC-6avyA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		5 / 12 VAL A 200
HIS A 230
ASP A 197
GLY A  40
SER A 126
 None
 0.96A 3sufB-6avyA:
undetectable		 3sufB-6avyA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		6 / 11 ASN A 153
VAL A 152
TYR A 144
LEU A 189
ALA A 104
SER A 135
 None
 1.44A 4m83A-6avyA:
undetectable		 4m83A-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		5 / 11 ASN A 153
VAL A 152
TYR A 144
ALA A 104
SER A 135
 None
 1.32A 4m83B-6avyA:
undetectable		 4m83B-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		4 / 4 PHE A  84
VAL A  86
ALA A  82
PHE A  75
 None
 1.49A 4w5qA-6avyA:
4.6		 4w5qA-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		4 / 4 PHE A  84
VAL A  86
ALA A  82
PHE A  75
 None
 1.50A 4w5rA-6avyA:
4.6		 4w5rA-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		4 / 4 PHE A  84
VAL A  86
ALA A  82
PHE A  75
 None
 1.48A 4z4gA-6avyA:
4.6		 4z4gA-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		3 / 3 TYR A  19
TYR A 150
SER A 135
 None
 0.99A 5iktB-6avyA:
undetectable		 5iktB-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		4 / 4 PHE A  84
VAL A  86
ALA A  82
PHE A  75
 None
 1.49A 5ki6A-6avyA:
4.3		 5ki6A-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 6avy ACYL-PROTEIN
THIOESTERASE 2
(Zea
mays) 		5 / 9 ALA A 104
ALA A 132
SER A 135
VAL A  36
GLY A 128
 None
 1.07A 6bklA-6avyA:
undetectable
6bklB-6avyA:
undetectable
6bklC-6avyA:
undetectable
6bklD-6avyA:
undetectable		 6bklA-6avyA:
undetectable
6bklB-6avyA:
undetectable
6bklC-6avyA:
undetectable
6bklD-6avyA:
undetectable