SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ax6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 ALA A 791
VAL A 785
TRP A 782
 IOD  A 902 ( 3.9A)
None
None
 0.88A 1av2C-6ax6A:
undetectable
1av2D-6ax6A:
undetectable		 1av2C-6ax6A:
undetectable
1av2D-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 5 ASP A 827
HIS A 825
HIS A 869
HIS A 877
 FE2  A 934 ( 2.8A)
FE2  A 934 (-3.6A)
None
FE2  A 934 (-3.5A)
 1.09A 1ei6A-6ax6A:
undetectable		 1ei6A-6ax6A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 HIS A 825
ASP A 827
HIS A 877
VAL A 891
PHE A 893
 FE2  A 934 (-3.6A)
FE2  A 934 ( 2.8A)
FE2  A 934 (-3.5A)
None
None
 0.55A 1uobA-6ax6A:
9.5		 1uobA-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 HIS A 877
ASP A 827
HIS A 869
VAL A 891
PHE A 893
 FE2  A 934 (-3.5A)
FE2  A 934 ( 2.8A)
None
None
None
 1.23A 1uobA-6ax6A:
9.5		 1uobA-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A 808
HIS A 825
HIS A 877
VAL A 891
PHE A 893
 None
FE2  A 934 (-3.6A)
FE2  A 934 (-3.5A)
None
None
 0.79A 1uobA-6ax6A:
9.5		 1uobA-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A 808
HIS A 877
HIS A 869
VAL A 891
PHE A 893
 None
FE2  A 934 (-3.5A)
None
None
None
 1.15A 1uobA-6ax6A:
9.5		 1uobA-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		6 / 11 HIS A 825
ASP A 827
THR A 832
HIS A 877
ARG A 887
VAL A 891
 FE2  A 934 (-3.6A)
FE2  A 934 ( 2.8A)
None
FE2  A 934 (-3.5A)
IOD  A 923 (-3.4A)
None
 0.75A 1uofA-6ax6A:
8.3		 1uofA-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 ALA A 791
VAL A 785
TRP A 782
 IOD  A 902 ( 3.9A)
None
None
 0.87A 1w5uC-6ax6A:
undetectable
1w5uD-6ax6A:
undetectable		 1w5uC-6ax6A:
undetectable
1w5uD-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 LEU A 778
VAL A 776
LEU A 890
ASP A 770
 None
 0.73A 3cs9D-6ax6A:
undetectable		 3cs9D-6ax6A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 5 LEU A 778
TRP A 782
ILE A 835
ASN A 838
 None
None
None
IOD  A 907 ( 4.7A)
 1.40A 4i00A-6ax6A:
undetectable		 4i00A-6ax6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 VAL A 790
PHE A 810
LEU A 890
VAL A 785
THR A 803
 None
 1.26A 4kyaB-6ax6A:
undetectable		 4kyaB-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 VAL A 790
PHE A 810
LEU A 890
VAL A 785
THR A 803
 None
 1.25A 4kyaH-6ax6A:
undetectable		 4kyaH-6ax6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 GLY A 848
HIS A 869
THR A 867
ILE A 720
VAL A 724
 None
None
IOD  A 930 ( 3.7A)
None
None
 1.30A 4okwA-6ax6A:
undetectable		 4okwA-6ax6A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 6ax6 PROCOLLAGEN LYSYL
HYDROXYLASE AND
GLYCOSYLTRANSFERASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 11 ILE A 835
GLY A 864
ALA A 866
PHE A 715
LEU A 833
 None
 1.28A 5hw4B-6ax6A:
undetectable		 5hw4B-6ax6A:
undetectable