SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ax8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AO8_A_MTXA170_2 (DIHYDROFOLATE REDUCTASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 4	TRP A 228 LEU A 53 ARG A 145 THR A 147	None	1.49A	1ao8A-6ax8A: 0.0	1ao8A-6ax8A: 15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FFY_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 12	GLY A 20 GLY A 261 ASP A 263 HIS A 290 PHE A 292	ME8 A 801 (-3.6A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.7A) ME8 A 801 (-4.9A)	0.61A	1ffyA-6ax8A: 23.3	1ffyA-6ax8A: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FFY_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 12	HIS A 18 GLY A 20 GLY A 261 ASP A 263 HIS A 290	ME8 A 801 (-3.8A) ME8 A 801 (-3.6A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.7A)	0.55A	1ffyA-6ax8A: 23.3	1ffyA-6ax8A: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FFY_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 12	HIS A 21 GLY A 20 GLY A 261 ASP A 263 HIS A 290	ME8 A 801 (-4.3A) ME8 A 801 (-3.6A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.7A)	1.28A	1ffyA-6ax8A: 23.3	1ffyA-6ax8A: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FXH_B_PACB1001_0 (PENICILLIN ACYLASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 7	PHE A 288 PHE A 332 ALA A 289 ILE A 260	None	1.02A	1fxhA-6ax8A: undetectable 1fxhB-6ax8A: undetectable	1fxhA-6ax8A: undetectable 1fxhB-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PG2_A_ADNA552_1 (METHIONYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	9 / 11	ALA A 9 HIS A 18 GLY A 20 HIS A 21 GLU A 24 GLY A 261 ASP A 263 ILE A 264 HIS A 290	ME8 A 801 ( 3.8A) ME8 A 801 (-3.8A) ME8 A 801 (-3.6A) ME8 A 801 (-4.3A) ME8 A 801 (-3.6A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.1A) ME8 A 801 (-4.7A)	0.44A	1pg2A-6ax8A: 39.3	1pg2A-6ax8A: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PG2_A_ADNA552_1 (METHIONYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	6 / 11	GLY A 20 HIS A 18 GLY A 261 ASP A 263 ILE A 264 HIS A 290	ME8 A 801 (-3.6A) ME8 A 801 (-3.8A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.1A) ME8 A 801 (-4.7A)	1.14A	1pg2A-6ax8A: 39.3	1pg2A-6ax8A: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU2_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	6 / 12	GLY A 20 HIS A 18 GLY A 261 ASP A 263 HIS A 290 PHE A 292	ME8 A 801 (-3.6A) ME8 A 801 (-3.8A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.7A) ME8 A 801 (-4.9A)	1.09A	1qu2A-6ax8A: 23.3	1qu2A-6ax8A: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU2_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	6 / 12	GLY A 20 HIS A 21 GLY A 261 ASP A 263 HIS A 290 PHE A 292	ME8 A 801 (-3.6A) ME8 A 801 (-4.3A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.7A) ME8 A 801 (-4.9A)	0.54A	1qu2A-6ax8A: 23.3	1qu2A-6ax8A: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU2_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	6 / 12	HIS A 18 GLY A 20 HIS A 21 GLY A 261 ASP A 263 HIS A 290	ME8 A 801 (-3.8A) ME8 A 801 (-3.6A) ME8 A 801 (-4.3A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.7A)	0.52A	1qu2A-6ax8A: 23.3	1qu2A-6ax8A: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU3_A_MRCA993_1 (ISOLEUCYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 12	GLY A 20 HIS A 18 ASP A 263 HIS A 290 PHE A 292	ME8 A 801 (-3.6A) ME8 A 801 (-3.8A) ME8 A 801 (-3.1A) ME8 A 801 (-4.7A) ME8 A 801 (-4.9A)	1.32A	1qu3A-6ax8A: 27.5	1qu3A-6ax8A: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU3_A_MRCA993_1 (ISOLEUCYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 12	GLY A 20 HIS A 21 ASP A 263 HIS A 290 PHE A 292	ME8 A 801 (-3.6A) ME8 A 801 (-4.3A) ME8 A 801 (-3.1A) ME8 A 801 (-4.7A) ME8 A 801 (-4.9A)	0.64A	1qu3A-6ax8A: 27.5	1qu3A-6ax8A: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU3_A_MRCA993_1 (ISOLEUCYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 12	HIS A 18 GLY A 20 HIS A 21 ASP A 263 HIS A 290	ME8 A 801 (-3.8A) ME8 A 801 (-3.6A) ME8 A 801 (-4.3A) ME8 A 801 (-3.1A) ME8 A 801 (-4.7A)	0.62A	1qu3A-6ax8A: 27.5	1qu3A-6ax8A: 6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN0_B_T44B602_1 (TRANSTHYRETIN)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 7	LEU A 355 ALA A 460 LEU A 478 ALA A 359	None	1.11A	1sn0B-6ax8A: undetectable 1sn0D-6ax8A: undetectable	1sn0B-6ax8A: 21.88 1sn0D-6ax8A: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN0_B_T44B602_1 (TRANSTHYRETIN)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 7	LEU A 478 ALA A 359 LEU A 355 ALA A 460	None	1.10A	1sn0B-6ax8A: undetectable 1sn0D-6ax8A: undetectable	1sn0B-6ax8A: 21.88 1sn0D-6ax8A: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KUH_A_HLTA150_1 (CALMODULIN)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 6	MET A 407 LEU A 327 GLU A 24 MET A 259	None None ME8 A 801 (-3.6A) None	1.02A	2kuhA-6ax8A: undetectable	2kuhA-6ax8A: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q6O_A_SAMA500_0 (HYPOTHETICAL PROTEIN)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 7	VAL A 492 ALA A 489 PRO A 496 THR A 498	None	0.90A	2q6oA-6ax8A: undetectable	2q6oA-6ax8A: undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_A_ADNA601_1 (METHIONYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	10 / 11	ALA A 9 ALA A 11 HIS A 18 GLY A 20 HIS A 21 GLU A 24 GLY A 261 ASP A 263 ILE A 264 HIS A 290	ME8 A 801 ( 3.8A) ME8 A 801 (-3.1A) ME8 A 801 (-3.8A) ME8 A 801 (-3.6A) ME8 A 801 (-4.3A) ME8 A 801 (-3.6A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.1A) ME8 A 801 (-4.7A)	0.38A	2x1lA-6ax8A: 54.3	2x1lA-6ax8A: 51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_A_ADNA601_1 (METHIONYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	6 / 11	GLY A 20 HIS A 18 GLY A 261 ASP A 263 ILE A 264 HIS A 290	ME8 A 801 (-3.6A) ME8 A 801 (-3.8A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.1A) ME8 A 801 (-4.7A)	1.09A	2x1lA-6ax8A: 54.3	2x1lA-6ax8A: 51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_B_ADNB601_1 (METHIONYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	11 / 12	ALA A 9 ALA A 11 HIS A 18 GLY A 20 HIS A 21 GLU A 24 GLY A 261 ASP A 263 ILE A 264 HIS A 290 LEU A 293	ME8 A 801 ( 3.8A) ME8 A 801 (-3.1A) ME8 A 801 (-3.8A) ME8 A 801 (-3.6A) ME8 A 801 (-4.3A) ME8 A 801 (-3.6A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.1A) ME8 A 801 (-4.7A) ME8 A 801 (-4.5A)	0.30A	2x1lB-6ax8A: 52.2	2x1lB-6ax8A: 51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_B_ADNB601_1 (METHIONYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	6 / 12	GLY A 20 HIS A 18 GLY A 261 ASP A 263 ILE A 264 HIS A 290	ME8 A 801 (-3.6A) ME8 A 801 (-3.8A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.1A) ME8 A 801 (-4.7A)	1.08A	2x1lB-6ax8A: 52.2	2x1lB-6ax8A: 51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_C_ADNC601_1 (METHIONYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	10 / 11	ALA A 9 ALA A 11 HIS A 18 GLY A 20 HIS A 21 GLU A 24 GLY A 261 ASP A 263 ILE A 264 HIS A 290	ME8 A 801 ( 3.8A) ME8 A 801 (-3.1A) ME8 A 801 (-3.8A) ME8 A 801 (-3.6A) ME8 A 801 (-4.3A) ME8 A 801 (-3.6A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.1A) ME8 A 801 (-4.7A)	0.30A	2x1lC-6ax8A: 52.0	2x1lC-6ax8A: 51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X1L_C_ADNC601_1 (METHIONYL-TRNA SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	6 / 11	GLY A 20 HIS A 18 GLY A 261 ASP A 263 ILE A 264 HIS A 290	ME8 A 801 (-3.6A) ME8 A 801 (-3.8A) ME8 A 801 (-2.9A) ME8 A 801 (-3.1A) ME8 A 801 (-4.1A) ME8 A 801 (-4.7A)	1.09A	2x1lC-6ax8A: 52.0	2x1lC-6ax8A: 51.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DEU_A_SALA301_1 (TRANSCRIPTIONAL REGULATOR SLYA)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 6	ILE A 116 TRP A 107 VAL A 217 HIS A 220	None	1.32A	3deuA-6ax8A: 0.9	3deuA-6ax8A: 16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JWQ_D_VIAD901_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 11	ARG A 33 HIS A 290 ALA A 11 LEU A 84 GLN A 81	None ME8 A 801 (-4.7A) ME8 A 801 (-3.1A) None None	1.49A	3jwqA-6ax8A: undetectable 3jwqD-6ax8A: undetectable	3jwqA-6ax8A: 12.38 3jwqD-6ax8A: 12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRK_D_CAMD502_0 (CAMPHOR 5-MONOOXYGENASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 5	LEU A 475 GLY A 479 THR A 498 VAL A 374	None	1.08A	3wrkD-6ax8A: undetectable	3wrkD-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BLV_A_SAMA1281_1 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 6	HIS A 51 HIS A 99 ASP A 129 ASP A 49	None None None ME8 A 801 (-4.1A)	1.31A	4blvA-6ax8A: undetectable	4blvA-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_A_SAMA301_0 (PANTOTHENATE SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 12	HIS A 18 GLY A 20 VAL A 227 GLY A 261 ASP A 263	ME8 A 801 (-3.8A) ME8 A 801 (-3.6A) None ME8 A 801 (-2.9A) ME8 A 801 (-3.1A)	0.99A	5hg0A-6ax8A: 5.8	5hg0A-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_B_SAMB301_0 (PANTOTHENATE SYNTHETASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	6 / 12	HIS A 18 GLY A 20 HIS A 21 VAL A 227 GLY A 261 ASP A 263	ME8 A 801 (-3.8A) ME8 A 801 (-3.6A) ME8 A 801 (-4.3A) None ME8 A 801 (-2.9A) ME8 A 801 (-3.1A)	1.02A	5hg0B-6ax8A: 5.8	5hg0B-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWA_A_GCSA302_1 (CHITOSANASE)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 7	THR A 94 ASP A 49 ASP A 230 GLY A 52	None ME8 A 801 (-4.1A) None None	0.95A	5hwaA-6ax8A: undetectable	5hwaA-6ax8A: 16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IWU_A_ERYA404_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 12	ILE A 260 HIS A 268 PHE A 332 ALA A 27 PHE A 183	None ME8 A 801 (-4.6A) None None None	1.44A	5iwuA-6ax8A: undetectable	5iwuA-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJD_A_RTLA201_0 (RETINOL-BINDING PROTEIN 1)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 9	LEU A 388 LEU A 494 ILE A 463 LEU A 418 MET A 417	None	1.37A	5ljdA-6ax8A: undetectable	5ljdA-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_A_CVIA301_0 (REGULATORY PROTEIN TETR)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 12	MET A 417 GLU A 396 LEU A 394 ILE A 458 TYR A 450	None	1.45A	5vlmA-6ax8A: undetectable	5vlmA-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W97_B_CHDB301_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2 CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	5 / 11	ARG A 208 PHE A 132 GLY A 123 THR A 147 THR A 138	None	1.22A	5w97G-6ax8A: undetectable 5w97a-6ax8A: 1.0 5w97b-6ax8A: undetectable	5w97G-6ax8A: undetectable 5w97a-6ax8A: undetectable 5w97b-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A7P_A_9SCA601_1 (SERUM ALBUMIN)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 5	ASN A 357 VAL A 455 LEU A 387 SER A 426	None	1.31A	6a7pA-6ax8A: undetectable	6a7pA-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CNK_A_NCTA405_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	4 / 6	TYR A 5 THR A 46 TYR A 235 THR A 28	None	1.05A	6cnkA-6ax8A: 4.6 6cnkB-6ax8A: 4.6	6cnkA-6ax8A: 16.28 6cnkB-6ax8A: 16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGC_A_ACTA813_0 (GEPHYRIN)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	3 / 3	THR A 237 ALA A 102 LYS A 104	None	0.63A	6fgcA-6ax8A: undetectable	6fgcA-6ax8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA817_0 (GEPHYRIN)	6ax8	METHIONINE-TRNA LIGASE (Mycobacterium tuberculosis)	3 / 3	THR A 237 ALA A 102 LYS A 104	None	0.63A	6fgdA-6ax8A: 2.5	6fgdA-6ax8A: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AO8_A_MTXA170_2","DIHYDROFOLATE REDUCTASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"TRP A 228;LEU A  53;ARG A 145;THR A 147","None","1.49A","1ao8A-6ax8A:0.0","1ao8A-6ax8A:15.85"],["1FFY_A_MRCA1993_1","ISOLEUCYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"GLY A  20;GLY A 261;ASP A 263;HIS A 290;PHE A 292","ME8 A 801 (-3.6A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.7A);ME8 A 801 (-4.9A)","0.61A","1ffyA-6ax8A:23.3","1ffyA-6ax8A:6.23"],["1FFY_A_MRCA1993_1","ISOLEUCYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"HIS A  18;GLY A  20;GLY A 261;ASP A 263;HIS A 290","ME8 A 801 (-3.8A);ME8 A 801 (-3.6A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.7A)","0.55A","1ffyA-6ax8A:23.3","1ffyA-6ax8A:6.23"],["1FFY_A_MRCA1993_1","ISOLEUCYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"HIS A  21;GLY A  20;GLY A 261;ASP A 263;HIS A 290","ME8 A 801 (-4.3A);ME8 A 801 (-3.6A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.7A)","1.28A","1ffyA-6ax8A:23.3","1ffyA-6ax8A:6.23"],["1FXH_B_PACB1001_0","PENICILLIN ACYLASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"PHE A 288;PHE A 332;ALA A 289;ILE A 260","None","1.02A","1fxhA-6ax8A:undetectable;1fxhB-6ax8A:undetectable","1fxhA-6ax8A:undetectable;1fxhB-6ax8A:undetectable"],["1PG2_A_ADNA552_1","METHIONYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",9,"ALA A   9;HIS A  18;GLY A  20;HIS A  21;GLU A  24;GLY A 261;ASP A 263;ILE A 264;HIS A 290","ME8 A 801 ( 3.8A);ME8 A 801 (-3.8A);ME8 A 801 (-3.6A);ME8 A 801 (-4.3A);ME8 A 801 (-3.6A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.1A);ME8 A 801 (-4.7A)","0.44A","1pg2A-6ax8A:39.3","1pg2A-6ax8A:8.96"],["1PG2_A_ADNA552_1","METHIONYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",6,"GLY A  20;HIS A  18;GLY A 261;ASP A 263;ILE A 264;HIS A 290","ME8 A 801 (-3.6A);ME8 A 801 (-3.8A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.1A);ME8 A 801 (-4.7A)","1.14A","1pg2A-6ax8A:39.3","1pg2A-6ax8A:8.96"],["1QU2_A_MRCA1993_1","ISOLEUCYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",6,"GLY A  20;HIS A  18;GLY A 261;ASP A 263;HIS A 290;PHE A 292","ME8 A 801 (-3.6A);ME8 A 801 (-3.8A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.7A);ME8 A 801 (-4.9A)","1.09A","1qu2A-6ax8A:23.3","1qu2A-6ax8A:6.23"],["1QU2_A_MRCA1993_1","ISOLEUCYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",6,"GLY A  20;HIS A  21;GLY A 261;ASP A 263;HIS A 290;PHE A 292","ME8 A 801 (-3.6A);ME8 A 801 (-4.3A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.7A);ME8 A 801 (-4.9A)","0.54A","1qu2A-6ax8A:23.3","1qu2A-6ax8A:6.23"],["1QU2_A_MRCA1993_1","ISOLEUCYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",6,"HIS A  18;GLY A  20;HIS A  21;GLY A 261;ASP A 263;HIS A 290","ME8 A 801 (-3.8A);ME8 A 801 (-3.6A);ME8 A 801 (-4.3A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.7A)","0.52A","1qu2A-6ax8A:23.3","1qu2A-6ax8A:6.23"],["1QU3_A_MRCA993_1","ISOLEUCYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"GLY A  20;HIS A  18;ASP A 263;HIS A 290;PHE A 292","ME8 A 801 (-3.6A);ME8 A 801 (-3.8A);ME8 A 801 (-3.1A);ME8 A 801 (-4.7A);ME8 A 801 (-4.9A)","1.32A","1qu3A-6ax8A:27.5","1qu3A-6ax8A:6.23"],["1QU3_A_MRCA993_1","ISOLEUCYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"GLY A  20;HIS A  21;ASP A 263;HIS A 290;PHE A 292","ME8 A 801 (-3.6A);ME8 A 801 (-4.3A);ME8 A 801 (-3.1A);ME8 A 801 (-4.7A);ME8 A 801 (-4.9A)","0.64A","1qu3A-6ax8A:27.5","1qu3A-6ax8A:6.23"],["1QU3_A_MRCA993_1","ISOLEUCYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"HIS A  18;GLY A  20;HIS A  21;ASP A 263;HIS A 290","ME8 A 801 (-3.8A);ME8 A 801 (-3.6A);ME8 A 801 (-4.3A);ME8 A 801 (-3.1A);ME8 A 801 (-4.7A)","0.62A","1qu3A-6ax8A:27.5","1qu3A-6ax8A:6.23"],["1SN0_B_T44B602_1","TRANSTHYRETIN;TRANSTHYRETIN","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"LEU A 355;ALA A 460;LEU A 478;ALA A 359","None","1.11A","1sn0B-6ax8A:undetectable;1sn0D-6ax8A:undetectable","1sn0B-6ax8A:21.88;1sn0D-6ax8A:21.88"],["1SN0_B_T44B602_1","TRANSTHYRETIN;TRANSTHYRETIN","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"LEU A 478;ALA A 359;LEU A 355;ALA A 460","None","1.10A","1sn0B-6ax8A:undetectable;1sn0D-6ax8A:undetectable","1sn0B-6ax8A:21.88;1sn0D-6ax8A:21.88"],["2KUH_A_HLTA150_1","CALMODULIN","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"MET A 407;LEU A 327;GLU A  24;MET A 259","None;None;ME8 A 801 (-3.6A);None","1.02A","2kuhA-6ax8A:undetectable","2kuhA-6ax8A:20.93"],["2Q6O_A_SAMA500_0","HYPOTHETICAL PROTEIN","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"VAL A 492;ALA A 489;PRO A 496;THR A 498","None","0.90A","2q6oA-6ax8A:undetectable","2q6oA-6ax8A:undetectable"],["2X1L_A_ADNA601_1","METHIONYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",10,"ALA A   9;ALA A  11;HIS A  18;GLY A  20;HIS A  21;GLU A  24;GLY A 261;ASP A 263;ILE A 264;HIS A 290","ME8 A 801 ( 3.8A);ME8 A 801 (-3.1A);ME8 A 801 (-3.8A);ME8 A 801 (-3.6A);ME8 A 801 (-4.3A);ME8 A 801 (-3.6A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.1A);ME8 A 801 (-4.7A)","0.38A","2x1lA-6ax8A:54.3","2x1lA-6ax8A:51.67"],["2X1L_A_ADNA601_1","METHIONYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",6,"GLY A  20;HIS A  18;GLY A 261;ASP A 263;ILE A 264;HIS A 290","ME8 A 801 (-3.6A);ME8 A 801 (-3.8A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.1A);ME8 A 801 (-4.7A)","1.09A","2x1lA-6ax8A:54.3","2x1lA-6ax8A:51.67"],["2X1L_B_ADNB601_1","METHIONYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",11,"ALA A   9;ALA A  11;HIS A  18;GLY A  20;HIS A  21;GLU A  24;GLY A 261;ASP A 263;ILE A 264;HIS A 290;LEU A 293","ME8 A 801 ( 3.8A);ME8 A 801 (-3.1A);ME8 A 801 (-3.8A);ME8 A 801 (-3.6A);ME8 A 801 (-4.3A);ME8 A 801 (-3.6A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.1A);ME8 A 801 (-4.7A);ME8 A 801 (-4.5A)","0.30A","2x1lB-6ax8A:52.2","2x1lB-6ax8A:51.67"],["2X1L_B_ADNB601_1","METHIONYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",6,"GLY A  20;HIS A  18;GLY A 261;ASP A 263;ILE A 264;HIS A 290","ME8 A 801 (-3.6A);ME8 A 801 (-3.8A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.1A);ME8 A 801 (-4.7A)","1.08A","2x1lB-6ax8A:52.2","2x1lB-6ax8A:51.67"],["2X1L_C_ADNC601_1","METHIONYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",10,"ALA A   9;ALA A  11;HIS A  18;GLY A  20;HIS A  21;GLU A  24;GLY A 261;ASP A 263;ILE A 264;HIS A 290","ME8 A 801 ( 3.8A);ME8 A 801 (-3.1A);ME8 A 801 (-3.8A);ME8 A 801 (-3.6A);ME8 A 801 (-4.3A);ME8 A 801 (-3.6A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.1A);ME8 A 801 (-4.7A)","0.30A","2x1lC-6ax8A:52.0","2x1lC-6ax8A:51.67"],["2X1L_C_ADNC601_1","METHIONYL-TRNA SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",6,"GLY A  20;HIS A  18;GLY A 261;ASP A 263;ILE A 264;HIS A 290","ME8 A 801 (-3.6A);ME8 A 801 (-3.8A);ME8 A 801 (-2.9A);ME8 A 801 (-3.1A);ME8 A 801 (-4.1A);ME8 A 801 (-4.7A)","1.09A","2x1lC-6ax8A:52.0","2x1lC-6ax8A:51.67"],["3DEU_A_SALA301_1","TRANSCRIPTIONAL REGULATOR SLYA","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"ILE A 116;TRP A 107;VAL A 217;HIS A 220","None","1.32A","3deuA-6ax8A:0.9","3deuA-6ax8A:16.88"],["3JWQ_D_VIAD901_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA;CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"ARG A  33;HIS A 290;ALA A  11;LEU A  84;GLN A  81","None;ME8 A 801 (-4.7A);ME8 A 801 (-3.1A);None;None","1.49A","3jwqA-6ax8A:undetectable;3jwqD-6ax8A:undetectable","3jwqA-6ax8A:12.38;3jwqD-6ax8A:12.38"],["3WRK_D_CAMD502_0","CAMPHOR 5-MONOOXYGENASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"LEU A 475;GLY A 479;THR A 498;VAL A 374","None","1.08A","3wrkD-6ax8A:undetectable","3wrkD-6ax8A:undetectable"],["4BLV_A_SAMA1281_1","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"HIS A  51;HIS A  99;ASP A 129;ASP A  49","None;None;None;ME8 A 801 (-4.1A)","1.31A","4blvA-6ax8A:undetectable","4blvA-6ax8A:undetectable"],["5HG0_A_SAMA301_0","PANTOTHENATE SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"HIS A  18;GLY A  20;VAL A 227;GLY A 261;ASP A 263","ME8 A 801 (-3.8A);ME8 A 801 (-3.6A);None;ME8 A 801 (-2.9A);ME8 A 801 (-3.1A)","0.99A","5hg0A-6ax8A:5.8","5hg0A-6ax8A:undetectable"],["5HG0_B_SAMB301_0","PANTOTHENATE SYNTHETASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",6,"HIS A  18;GLY A  20;HIS A  21;VAL A 227;GLY A 261;ASP A 263","ME8 A 801 (-3.8A);ME8 A 801 (-3.6A);ME8 A 801 (-4.3A);None;ME8 A 801 (-2.9A);ME8 A 801 (-3.1A)","1.02A","5hg0B-6ax8A:5.8","5hg0B-6ax8A:undetectable"],["5HWA_A_GCSA302_1","CHITOSANASE","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"THR A  94;ASP A  49;ASP A 230;GLY A  52","None;ME8 A 801 (-4.1A);None;None","0.95A","5hwaA-6ax8A:undetectable","5hwaA-6ax8A:16.74"],["5IWU_A_ERYA404_0","MACROLIDE 2'-PHOSPHOTRANSFERASE II","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"ILE A 260;HIS A 268;PHE A 332;ALA A  27;PHE A 183","None;ME8 A 801 (-4.6A);None;None;None","1.44A","5iwuA-6ax8A:undetectable","5iwuA-6ax8A:undetectable"],["5LJD_A_RTLA201_0","RETINOL-BINDING PROTEIN 1","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"LEU A 388;LEU A 494;ILE A 463;LEU A 418;MET A 417","None","1.37A","5ljdA-6ax8A:undetectable","5ljdA-6ax8A:undetectable"],["5VLM_A_CVIA301_0","REGULATORY PROTEIN TETR","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"MET A 417;GLU A 396;LEU A 394;ILE A 458;TYR A 450","None","1.45A","5vlmA-6ax8A:undetectable","5vlmA-6ax8A:undetectable"],["5W97_B_CHDB301_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 2;CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",5,"ARG A 208;PHE A 132;GLY A 123;THR A 147;THR A 138","None","1.22A","5w97G-6ax8A:undetectable;5w97a-6ax8A:1.0;5w97b-6ax8A:undetectable","5w97G-6ax8A:undetectable;5w97a-6ax8A:undetectable;5w97b-6ax8A:undetectable"],["6A7P_A_9SCA601_1","SERUM ALBUMIN","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"ASN A 357;VAL A 455;LEU A 387;SER A 426","None","1.31A","6a7pA-6ax8A:undetectable","6a7pA-6ax8A:undetectable"],["6CNK_A_NCTA405_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",4,"TYR A   5;THR A  46;TYR A 235;THR A  28","None","1.05A","6cnkA-6ax8A:4.6;6cnkB-6ax8A:4.6","6cnkA-6ax8A:16.28;6cnkB-6ax8A:16.28"],["6FGC_A_ACTA813_0","GEPHYRIN","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",3,"THR A 237;ALA A 102;LYS A 104","None","0.63A","6fgcA-6ax8A:undetectable","6fgcA-6ax8A:undetectable"],["6FGD_A_ACTA817_0","GEPHYRIN","6ax8","METHIONINE-TRNA LIGASE","Mycobacterium tuberculosis",3,"THR A 237;ALA A 102;LYS A 104","None","0.63A","6fgdA-6ax8A:2.5","6fgdA-6ax8A:undetectable"]]