SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6axe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		3 / 3 GLN A  61
HIS A 473
PRO A 710
 None
 0.12A 1d8cA-6axeA:
52.6		 1d8cA-6axeA:
57.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		6 / 12 ILE A 243
ALA A 255
LEU A 211
VAL A 180
LEU A 232
ILE A 230
 None
 1.44A 1df7A-6axeA:
undetectable		 1df7A-6axeA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 10 MET A 270
LEU A 336
LEU A 335
GLU A 108
ARG A 393
 None
 1.33A 1gwrA-6axeA:
undetectable		 1gwrA-6axeA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		3 / 3 GLU A 601
TRP A 651
LYS A 517
 None
 1.04A 1qu2A-6axeA:
undetectable		 1qu2A-6axeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 11 ALA A 513
ILE A 460
GLY A 434
ALA A 454
ILE A 100
 None
 1.03A 2idwA-6axeA:
undetectable		 2idwA-6axeA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 10 LEU A 344
LEU A  54
THR A 413
ARG A  57
GLU A 409
 None
 1.46A 2j1gE-6axeA:
undetectable
2j1gF-6axeA:
undetectable		 2j1gE-6axeA:
14.93
2j1gF-6axeA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 4 LEU A 583
THR A 584
ILE A  64
HIS A  68
 None
 1.20A 2jfaB-6axeA:
undetectable		 2jfaB-6axeA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 6 HIS A 555
GLN A 514
ALA A 265
THR A 268
 None
 1.04A 2xfhA-6axeA:
undetectable		 2xfhA-6axeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 12 PHE A 126
ALA A 127
ASN A 290
GLY A 293
LEU A 286
 ACO  A 801 (-3.6A)
None
None
None
None
 1.23A 3aobC-6axeA:
undetectable		 3aobC-6axeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 12 PHE A 126
ALA A 127
ASN A 290
GLY A 293
LEU A 286
 ACO  A 801 (-3.6A)
None
None
None
None
 1.39A 3aodC-6axeA:
undetectable		 3aodC-6axeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 10 ALA A 513
ILE A 460
GLY A 434
ALA A 454
ILE A 100
 None
 0.98A 3ekwA-6axeA:
undetectable		 3ekwA-6axeA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 10 GLY A 479
ALA A 478
ILE A  64
ILE A 472
THR A 584
 None
 0.93A 3el9B-6axeA:
undetectable		 3el9B-6axeA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 10 ILE A 366
GLY A 365
PRO A 361
VAL A 351
ILE A 350
 None
 1.08A 3em4V-6axeA:
undetectable		 3em4V-6axeA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		3 / 3 ARG A 339
GLU A 364
ASP A 280
 ACO  A 801 (-3.3A)
None
None
 0.90A 3g2oA-6axeA:
undetectable		 3g2oA-6axeA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 5 ASP A 466
ASP A 274
PRO A 402
GLU A 438
 MG  A 802 (-3.2A)
MG  A 802 ( 4.5A)
None
MG  A 802 (-2.7A)
 1.42A 3l2wA-6axeA:
undetectable		 3l2wA-6axeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 10 VAL A 105
PHE A 509
ALA A 454
ILE A 435
VAL A 433
 None
 1.10A 3me6A-6axeA:
undetectable		 3me6A-6axeA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 10 MET A 270
LEU A 336
LEU A 335
GLU A 108
ARG A 393
 None
 1.26A 3ollA-6axeA:
undetectable		 3ollA-6axeA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 9 MET A 270
LEU A 336
LEU A 335
GLU A 108
ARG A 393
 None
 1.26A 3ollB-6axeA:
0.0		 3ollB-6axeA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 6 ASN A 315
TYR A 320
GLU A 240
ILE A 261
 None
 1.14A 3q5sA-6axeA:
undetectable		 3q5sA-6axeA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		3 / 3 ARG A 642
LYS A 403
ARG A 638
 None
MG  A 802 ( 4.1A)
None
 1.11A 3w1wA-6axeA:
2.4
3w1wB-6axeA:
2.5		 3w1wA-6axeA:
19.41
3w1wB-6axeA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		3 / 3 ARG A 638
ARG A 642
LYS A 403
 None
None
MG  A 802 ( 4.1A)
 1.14A 3w1wA-6axeA:
2.4
3w1wB-6axeA:
2.5		 3w1wA-6axeA:
19.41
3w1wB-6axeA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 12 GLN A 536
ALA A 544
GLN A 116
ARG A 134
GLU A 263
 None
 1.22A 4azwA-6axeA:
undetectable		 4azwA-6axeA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 12 GLY A 655
VAL A 656
ILE A 657
LEU A 647
ILE A 609
 None
 1.06A 4pd4C-6axeA:
undetectable		 4pd4C-6axeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 11 GLY A 504
ILE A 460
GLY A 511
ILE A 100
PHE A  98
 None
 0.92A 4qoiA-6axeA:
undetectable
4qoiB-6axeA:
undetectable		 4qoiA-6axeA:
16.35
4qoiB-6axeA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 9 THR A 110
ILE A 515
LEU A 335
VAL A 400
PHE A 509
 None
 1.15A 4r38C-6axeA:
undetectable		 4r38C-6axeA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 6 SER A 644
GLY A 611
GLU A 636
ASP A 674
 None
 1.02A 4uckB-6axeA:
undetectable		 4uckB-6axeA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 7 TYR A 559
VAL A 564
ILE A 515
HIS A 555
 None
 1.14A 4xo7B-6axeA:
9.7		 4xo7B-6axeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		3 / 3 GLU A 263
HIS A 238
ASP A 107
 None
 0.83A 5c0oG-6axeA:
undetectable		 5c0oG-6axeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 7 LEU A 374
VAL A 423
ILE A 350
VAL A  39
 None
 1.17A 5jh7C-6axeA:
undetectable		 5jh7C-6axeA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 12 VAL A 602
ALA A 662
SER A 665
ARG A 653
GLN A 708
 None
 1.16A 5syfB-6axeA:
undetectable		 5syfB-6axeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		3 / 3 THR A 474
MET A 476
HIS A  68
 None
 0.84A 5uunA-6axeA:
undetectable		 5uunA-6axeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 12 CYH A 606
ALA A 670
PRO A 671
ASP A 603
LEU A 648
 None
 1.16A 5wwsA-6axeA:
undetectable		 5wwsA-6axeA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 5 THR A  56
THR A  47
GLN A  51
ASP A  45
 None
 1.46A 6ectA-6axeA:
undetectable		 6ectA-6axeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 5 THR A  56
THR A  47
GLN A  51
ASP A  45
 None
 1.40A 6ecxA-6axeA:
undetectable		 6ecxA-6axeA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 7 ILE A 269
GLN A 116
VAL A 400
TRP A 291
 None
 0.92A 6j20A-6axeA:
undetectable		 6j20A-6axeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		5 / 12 TYR A  81
ARG A 440
TRP A  67
PHE A  84
ILE A 472
 ACT  A 803 ( 3.9A)
None
None
None
None
 1.20A 6mkeB-6axeA:
undetectable
6mkeC-6axeA:
undetectable		 6mkeB-6axeA:
9.11
6mkeC-6axeA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6axe MALATE SYNTHASE G
(Mycobacterium
marinum) 		4 / 8 TRP A 616
HIS A 719
ARG A 642
GLU A 438
 None
None
None
MG  A 802 (-2.7A)
 1.13A 6mn4C-6axeA:
undetectable		 6mn4C-6axeA:
20.76