SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6axf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		3 / 3 LEU A 364
LEU A 149
MET A 210
 None
 0.81A 1ya3B-6axfA:
undetectable		 1ya3B-6axfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		3 / 3 TRP A 206
VAL A 354
ARG A 351
 None
 0.82A 3b0wA-6axfA:
undetectable		 3b0wA-6axfA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		3 / 3 LEU A 361
ARG A 351
ASN A 239
 None
 0.77A 3qxvD-6axfA:
undetectable		 3qxvD-6axfA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU A 279
VAL A 247
TYR A 289
LEU A 235
 None
 1.11A 3v81C-6axfA:
undetectable		 3v81C-6axfA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		3 / 3 VAL A 265
SER A 266
THR A 269
 None
 0.46A 4luhA-6axfA:
2.8		 4luhA-6axfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		4 / 8 THR A 242
GLY A 249
GLY A 248
VAL A 247
 None
 0.80A 4qvvK-6axfA:
undetectable
4qvvL-6axfA:
undetectable		 4qvvK-6axfA:
18.43
4qvvL-6axfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		4 / 8 THR A 242
GLY A 249
GLY A 248
VAL A 247
 None
 0.80A 4qvvY-6axfA:
undetectable
4qvvZ-6axfA:
undetectable		 4qvvY-6axfA:
18.43
4qvvZ-6axfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		4 / 6 CYH A  20
LEU A  40
HIS A  77
LEU A  78
 None
 1.04A 5hpuC-6axfA:
undetectable
5hpuD-6axfA:
undetectable		 5hpuC-6axfA:
6.51
5hpuD-6axfA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 368
TRP A 206
LEU A 364
PHE A 227
ALA A 245
 None
 1.05A 5ieoA-6axfA:
undetectable		 5ieoA-6axfA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 368
TRP A 206
LEU A 364
PHE A 227
ALA A 245
 None
 1.06A 5iepA-6axfA:
undetectable		 5iepA-6axfA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		5 / 12 PRO A  94
ILE A  83
LEU A  40
LEU A  56
LEU A  78
 None
 1.18A 5tiwA-6axfA:
undetectable		 5tiwA-6axfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A 314
LEU A 318
MET A  42
TYR A 178
 None
 1.34A 5uc3A-6axfA:
undetectable		 5uc3A-6axfA:
11.95