SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6axg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 206
LEU A 290
ILE A 275
LEU A 297
THR A 210
 None
 1.22A 1ddrB-6axgA:
undetectable		 1ddrB-6axgA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 206
LEU A 290
ILE A 275
LEU A 297
THR A 210
 None
 1.17A 1ddsB-6axgA:
undetectable		 1ddsB-6axgA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		5 / 11 ALA A 206
LEU A 290
ILE A 275
LEU A 297
THR A 210
 None
 1.13A 1jomA-6axgA:
undetectable		 1jomA-6axgA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		4 / 5 ILE A 422
LEU A 425
SER A 426
ARG A 429
 None
 0.93A 2byoA-6axgA:
undetectable		 2byoA-6axgA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		3 / 3 SER A  71
GLN A 120
PHE A  69
 None
 0.50A 3g4lC-6axgA:
undetectable		 3g4lC-6axgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A 206
LEU A 290
ILE A 275
LEU A 297
THR A 210
 None
 1.18A 3ql0A-6axgA:
undetectable		 3ql0A-6axgA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		4 / 4 ASN A 288
SER A 249
ALA A 292
VAL A 293
 None
 1.29A 4x1kC-6axgA:
undetectable		 4x1kC-6axgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 413
TRP A 253
LEU A 409
PHE A 274
ALA A 292
 None
 1.06A 5ieoA-6axgA:
undetectable		 5ieoA-6axgA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 413
TRP A 253
LEU A 409
PHE A 274
ALA A 292
 None
 1.09A 5iepA-6axgA:
undetectable		 5iepA-6axgA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		4 / 5 ILE A 146
LEU A 124
HIS A 132
VAL A 135
 None
 1.21A 5jmnB-6axgA:
2.4		 5jmnB-6axgA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		3 / 3 HIS A  80
ASN A  83
ALA A  87
 None
 0.00A 5n4tB-6axgA:
undetectable		 5n4tB-6axgA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 392
LEU A 246
LEU A 351
GLY A 352
ALA A 292
 None
 1.30A 6qxsD-6axgA:
undetectable		 6qxsD-6axgA:
22.20