SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ay1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1F86_B_T44B528_1 (TRANSTHYRETIN THR119MET VARIANT)	6ay1	NUCLEOSIDE DIPHOSPHATE KINASE (Helicobacter pylori)	4 / 4	LYS A 84 LEU A 31 ALA A 81 LEU A 76	None	1.47A	1f86B-6ay1A: undetectable	1f86B-6ay1A: 18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO7_A_CHDA501_0 (FERROCHELATASE, MITOCHONDRIAL)	6ay1	NUCLEOSIDE DIPHOSPHATE KINASE (Helicobacter pylori)	5 / 12	MET A 66 LEU A 62 PHE A 58 ILE A 110 LEU A 6	None	1.21A	2po7A-6ay1A: undetectable	2po7A-6ay1A: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PST_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	6ay1	NUCLEOSIDE DIPHOSPHATE KINASE (Helicobacter pylori)	3 / 3	ILE A 9 ASP A 12 ARG A 38	None	0.81A	4pstA-6ay1A: undetectable	4pstA-6ay1A: 23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ND2_B_TA1B601_1 (TUBULIN BETA-2B CHAIN)	6ay1	NUCLEOSIDE DIPHOSPHATE KINASE (Helicobacter pylori)	5 / 12	VAL A 33 LEU A 39 ALA A 35 PHE A 132 LEU A 6	None	1.41A	5nd2B-6ay1A: undetectable	5nd2B-6ay1A: 16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_1 (PROTEIN CYP51)	6ay1	NUCLEOSIDE DIPHOSPHATE KINASE (Helicobacter pylori)	5 / 12	ALA A 129 MET A 66 PHE A 65 ALA A 112 ALA A 114	None	1.05A	6aycA-6ay1A: undetectable	6aycA-6ay1A: 20.14

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1F86_B_T44B528_1","TRANSTHYRETIN THR119MET VARIANT","6ay1","NUCLEOSIDE DIPHOSPHATE KINASE","Helicobacter pylori",4,"LYS A  84;LEU A  31;ALA A  81;LEU A  76","None","1.47A","1f86B-6ay1A:undetectable","1f86B-6ay1A:18.95"],["2PO7_A_CHDA501_0","FERROCHELATASE, MITOCHONDRIAL","6ay1","NUCLEOSIDE DIPHOSPHATE KINASE","Helicobacter pylori",5,"MET A  66;LEU A  62;PHE A  58;ILE A 110;LEU A   6","None","1.21A","2po7A-6ay1A:undetectable","2po7A-6ay1A:18.52"],["4PST_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","6ay1","NUCLEOSIDE DIPHOSPHATE KINASE","Helicobacter pylori",3,"ILE A   9;ASP A  12;ARG A  38","None","0.81A","4pstA-6ay1A:undetectable","4pstA-6ay1A:23.16"],["5ND2_B_TA1B601_1","TUBULIN BETA-2B CHAIN","6ay1","NUCLEOSIDE DIPHOSPHATE KINASE","Helicobacter pylori",5,"VAL A  33;LEU A  39;ALA A  35;PHE A 132;LEU A   6","None","1.41A","5nd2B-6ay1A:undetectable","5nd2B-6ay1A:16.19"],["6AYC_A_1YNA502_1","PROTEIN CYP51","6ay1","NUCLEOSIDE DIPHOSPHATE KINASE","Helicobacter pylori",5,"ALA A 129;MET A  66;PHE A  65;ALA A 112;ALA A 114","None","1.05A","6aycA-6ay1A:undetectable","6aycA-6ay1A:20.14"]]