SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ayi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 6ayi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR UIDR
(Escherichia
coli) 		3 / 3 THR A  14
THR A  12
PRO A  11
 None
 0.83A 1dscC-6ayiA:
undetectable		 1dscC-6ayiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6ayi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR UIDR
(Escherichia
coli) 		4 / 7 PHE A  83
MET A  87
VAL A  88
SER A  90
 None
C3G  A 201 (-4.5A)
None
C3G  A 201 ( 4.8A)
 0.74A 1wrlA-6ayiA:
undetectable
1wrlB-6ayiA:
undetectable		 1wrlA-6ayiA:
23.91
1wrlB-6ayiA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 6ayi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR UIDR
(Escherichia
coli) 		3 / 3 THR A  14
THR A  12
PRO A  11
 None
 0.87A 209dC-6ayiA:
undetectable		 209dC-6ayiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 6ayi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR UIDR
(Escherichia
coli) 		3 / 3 ASP A 161
ARG A 157
TYR A 164
 None
None
C3G  A 201 (-4.7A)
 0.91A 5a7mA-6ayiA:
undetectable		 5a7mA-6ayiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 6ayi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR UIDR
(Escherichia
coli) 		3 / 3 ASP A 161
ARG A 157
TYR A 164
 None
None
C3G  A 201 (-4.7A)
 0.90A 5a7mB-6ayiA:
undetectable		 5a7mB-6ayiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6ayi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR UIDR
(Escherichia
coli) 		4 / 7 HIS A 126
ILE A 108
VAL A 105
TYR A 164
 None
None
C3G  A 201 (-4.6A)
C3G  A 201 (-4.7A)
 1.29A 5kkzM-6ayiA:
undetectable
5kkzO-6ayiA:
undetectable		 5kkzM-6ayiA:
undetectable
5kkzO-6ayiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 6ayi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR UIDR
(Escherichia
coli) 		4 / 8 THR A 163
SER A 156
PHE A  83
TYR A  86
 C3G  A 201 (-3.2A)
None
None
None
 1.12A 6eqpA-6ayiA:
undetectable		 6eqpA-6ayiA:
19.32