SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ayv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 213
ALA A 212
LEU A 254
ILE A 203
LEU A 200
 None
 0.92A 1fm6U-6ayvA:
undetectable		 1fm6U-6ayvA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 134
VAL A 154
MET A 152
ARG A 175
LEU A 128
 GOL  A 404 ( 4.4A)
None
None
None
None
 1.22A 1n4hA-6ayvA:
undetectable		 1n4hA-6ayvA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 275
MET A  12
TYR A 278
CYH A 283
THR A 285
 GOL  A 411 ( 4.0A)
None
None
None
None
 1.47A 2vd0B-6ayvA:
undetectable		 2vd0B-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 252
ILE A 223
ALA A 264
ILE A  95
 None
 0.67A 2xkwA-6ayvA:
undetectable		 2xkwA-6ayvA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  95
ILE A 288
ILE A 300
LEU A  98
VAL A 184
 None
 0.95A 3fpjB-6ayvA:
undetectable		 3fpjB-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A  79
GLU A  51
GLY A  50
GLU A 208
 MG  A 402 (-2.7A)
None
None
F6P  A 401 ( 3.5A)
 1.44A 3w9tA-6ayvA:
undetectable		 3w9tA-6ayvA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A  79
GLU A  51
GLY A  50
GLU A 208
 MG  A 402 (-2.7A)
None
None
F6P  A 401 ( 3.5A)
 1.45A 3w9tC-6ayvA:
undetectable		 3w9tC-6ayvA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A  79
GLU A  51
GLY A  50
GLU A 208
 MG  A 402 (-2.7A)
None
None
F6P  A 401 ( 3.5A)
 1.45A 3w9tD-6ayvA:
undetectable		 3w9tD-6ayvA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A  79
GLU A  51
GLY A  50
GLU A 208
 MG  A 402 (-2.7A)
None
None
F6P  A 401 ( 3.5A)
 1.45A 3w9tG-6ayvA:
undetectable		 3w9tG-6ayvA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 107
ALA A 241
LEU A 245
LEU A 227
 None
 0.91A 4ejgC-6ayvA:
undetectable		 4ejgC-6ayvA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 162
LEU A 165
CYH A 155
LEU A 200
 None
GOL  A 404 ( 4.8A)
None
None
 1.41A 5hrqD-6ayvA:
undetectable
5hrqG-6ayvA:
undetectable
5hrqH-6ayvA:
undetectable		 5hrqD-6ayvA:
undetectable
5hrqG-6ayvA:
undetectable
5hrqH-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 188
VAL A 297
ILE A 211
ALA A 212
VAL A  97
 None
 1.05A 5n0sA-6ayvA:
3.6		 5n0sA-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 188
VAL A 297
ILE A 211
ALA A 212
VAL A  97
 None
 1.05A 5n0sB-6ayvA:
3.6		 5n0sB-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 188
VAL A 297
ILE A 211
ALA A 212
VAL A  97
 None
 1.05A 5n0tA-6ayvA:
3.7		 5n0tA-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 188
VAL A 297
ILE A 211
ALA A 212
VAL A  97
 None
 1.07A 5n0wB-6ayvA:
3.7		 5n0wB-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 188
VAL A 297
ILE A 211
ALA A 212
VAL A  97
 None
 1.05A 5n4iA-6ayvA:
3.4		 5n4iA-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 212
ALA A 119
GLY A 121
PHE A 262
ALA A 264
 None
 0.85A 5w4zA-6ayvA:
undetectable		 5w4zA-6ayvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		5 / 12 VAL A   4
ILE A 223
GLY A 220
ALA A 214
ALA A 213
 None
 1.03A 6c2mD-6ayvA:
undetectable		 6c2mD-6ayvA:
22.99