SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6az0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 351
LYS A 360
ARG A 363
 None
 0.52A 1ra8A-6az0A:
undetectable		 1ra8A-6az0A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 409
PHE A 366
ASN A 402
 None
 0.68A 1sg9B-6az0A:
2.5		 1sg9B-6az0A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 569
THR A 537
HIS A 540
GLU A 541
HIS A 544
 None
None
ZN  A 802 (-3.4A)
None
ZN  A 802 (-3.3A)
 0.52A 2jihA-6az0A:
undetectable		 2jihA-6az0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 569
THR A 537
HIS A 540
GLU A 541
HIS A 544
 None
None
ZN  A 802 (-3.4A)
None
ZN  A 802 (-3.3A)
 0.47A 2jihB-6az0A:
undetectable		 2jihB-6az0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 491
PHE A 511
ILE A 475
VAL A 470
LEU A 466
 None
 1.01A 2jn3A-6az0A:
undetectable		 2jn3A-6az0A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 481
ILE A 456
GLY A 285
LEU A 482
THR A 325
 None
ATP  A 801 ( 4.4A)
ATP  A 801 ( 4.2A)
None
ATP  A 801 (-4.3A)
 1.16A 3eeyA-6az0A:
undetectable		 3eeyA-6az0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 481
ILE A 456
GLY A 285
LEU A 482
THR A 325
 None
ATP  A 801 ( 4.4A)
ATP  A 801 ( 4.2A)
None
ATP  A 801 (-4.3A)
 1.15A 3eeyB-6az0A:
2.4		 3eeyB-6az0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 481
ILE A 456
GLY A 285
LEU A 482
THR A 325
 None
ATP  A 801 ( 4.4A)
ATP  A 801 ( 4.2A)
None
ATP  A 801 (-4.3A)
 1.15A 3eeyC-6az0A:
2.2		 3eeyC-6az0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 481
ILE A 456
GLY A 285
LEU A 482
THR A 325
 None
ATP  A 801 ( 4.4A)
ATP  A 801 ( 4.2A)
None
ATP  A 801 (-4.3A)
 1.12A 3eeyD-6az0A:
undetectable		 3eeyD-6az0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 420
ILE A 376
GLY A 416
LEU A 313
PRO A 303
 None
 1.05A 3em0B-6az0A:
undetectable		 3em0B-6az0A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 375
LEU A 365
PHE A 366
ILE A 379
LEU A 404
 None
 1.11A 3hj3A-6az0A:
undetectable		 3hj3A-6az0A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 569
THR A 537
HIS A 540
GLU A 541
HIS A 544
 None
None
ZN  A 802 (-3.4A)
None
ZN  A 802 (-3.3A)
 0.46A 3hy7A-6az0A:
undetectable		 3hy7A-6az0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 569
THR A 537
HIS A 540
GLU A 541
HIS A 544
 None
None
ZN  A 802 (-3.4A)
None
ZN  A 802 (-3.3A)
 0.41A 3hy7B-6az0A:
undetectable		 3hy7B-6az0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 541
GLY A 598
ILE A 600
ALA A 674
ASP A 618
 None
None
None
None
ZN  A 802 (-2.1A)
 1.08A 3nmuB-6az0A:
undetectable
3nmuJ-6az0A:
undetectable		 3nmuB-6az0A:
24.90
3nmuJ-6az0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 678
TYR A 606
GLY A 543
LEU A 688
HIS A 686
 None
 1.02A 3ou7B-6az0A:
undetectable		 3ou7B-6az0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 678
TYR A 606
ALA A 689
GLY A 543
HIS A 686
 None
 1.14A 3ou7C-6az0A:
2.4		 3ou7C-6az0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 678
TYR A 606
GLY A 543
LEU A 688
HIS A 686
 None
 1.01A 3ou7C-6az0A:
2.4		 3ou7C-6az0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 546
TYR A 550
LEU A 688
LEU A 557
 None
 0.70A 3ozwA-6az0A:
undetectable		 3ozwA-6az0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 330
ALA A 291
ARG A 290
LEU A 319
 None
 1.16A 3rd0A-6az0A:
2.7		 3rd0A-6az0A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 380
SER A 346
SER A 348
ILE A 385
GLY A 386
 MG  A 803 ( 4.3A)
None
None
None
None
 1.46A 4fxsA-6az0A:
undetectable		 4fxsA-6az0A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 365
GLY A 316
GLU A 292
PHE A 439
LEU A 429
 None
 1.30A 4retA-6az0A:
2.1		 4retA-6az0A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 365
GLY A 316
GLU A 292
PHE A 439
LEU A 429
 None
 1.30A 4retC-6az0A:
undetectable		 4retC-6az0A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 541
HIS A 544
VAL A 594
THR A 572
ALA A 560
 None
ZN  A 802 (-3.3A)
None
None
None
 1.36A 4ygfD-6az0A:
undetectable		 4ygfD-6az0A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 419
GLY A 421
THR A 423
LEU A 433
LEU A 429
 None
 1.34A 5fhzB-6az0A:
undetectable		 5fhzB-6az0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 419
GLY A 421
THR A 423
LEU A 433
LEU A 429
 None
 1.30A 5fhzC-6az0A:
undetectable		 5fhzC-6az0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 664
MET A 635
ASP A 669
 None
 0.77A 5h2uA-6az0A:
undetectable		 5h2uA-6az0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 279
ASP A 282
ARG A 332
 None
None
ATP  A 801 ( 4.1A)
 0.92A 5jwaA-6az0A:
undetectable
5jwaH-6az0A:
undetectable		 5jwaA-6az0A:
20.75
5jwaH-6az0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 379
ILE A 419
PHE A 366
ALA A 367
GLN A 368
 None
 1.16A 5nukA-6az0A:
undetectable		 5nukA-6az0A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 382
ILE A 362
PHE A 350
PHE A 439
ILE A 419
 None
 1.31A 6ebpA-6az0A:
undetectable		 6ebpA-6az0A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 293
THR A 334
ILE A 420
VAL A 317
ILE A 296
 None
 1.18A 6ef6A-6az0A:
undetectable		 6ef6A-6az0A:
21.54