SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6az6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 8 VAL A 109
SER A 154
ASN A 156
ASP A 160
 None
 1.17A 1hwiB-6az6A:
1.4		 1hwiB-6az6A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 7 VAL A 109
SER A 154
ASN A 156
ASP A 160
 None
 1.15A 1hwiC-6az6A:
undetectable		 1hwiC-6az6A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 7 VAL A 109
SER A 154
ASN A 156
ASP A 160
 None
 1.15A 1hwiD-6az6A:
undetectable		 1hwiD-6az6A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 8 VAL A 109
SER A 154
ASN A 156
ASP A 160
 None
 1.17A 1hwkA-6az6A:
1.7		 1hwkA-6az6A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 8 VAL A 109
SER A 154
ASN A 156
ASP A 160
 None
 1.16A 1hwkC-6az6A:
1.6		 1hwkC-6az6A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 8 VAL A 109
SER A 154
ASN A 156
ASP A 160
 None
 1.16A 1hwkD-6az6A:
undetectable		 1hwkD-6az6A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		3 / 3 ASP A 127
LEU A 120
LEU A 124
 None
 0.47A 1ikeA-6az6A:
undetectable		 1ikeA-6az6A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		3 / 3 ASP A 127
LEU A 120
LEU A 124
 None
 0.49A 1np1B-6az6A:
undetectable		 1np1B-6az6A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 5 LEU A  28
LEU A  16
LEU A  18
LEU A  34
 None
 1.12A 1yajD-6az6A:
undetectable		 1yajD-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		5 / 12 VAL A  49
LEU A  13
ILE A  17
ILE A  68
ALA A  26
 None
 1.22A 2gj5A-6az6A:
undetectable		 2gj5A-6az6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 5 VAL A   6
THR A   9
VAL A  40
GLY A  41
 None
 1.12A 2p2fA-6az6A:
undetectable		 2p2fA-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 4 VAL A   6
THR A   9
VAL A  40
GLY A  41
 None
 1.14A 2p2fB-6az6A:
undetectable		 2p2fB-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		5 / 10 ARG A 112
ILE A 113
ASN A 156
LEU A 121
LEU A 150
 None
 1.22A 3o02A-6az6A:
2.1
3o02B-6az6A:
2.2		 3o02A-6az6A:
13.40
3o02B-6az6A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 4 LYS A 152
GLU A 102
ILE A 105
SER A 154
 None
 1.49A 4acaC-6az6A:
undetectable		 4acaC-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		3 / 3 HIS A 212
GLU A 102
ASN A 167
 None
 0.90A 4bupB-6az6A:
undetectable		 4bupB-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 8 ARG A  98
VAL A 216
SER A 215
HIS A 212
 None
 0.83A 4qknA-6az6A:
2.3		 4qknA-6az6A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		3 / 3 LYS A 152
ASP A 160
ARG A 112
 None
 1.10A 5jwaA-6az6A:
undetectable
5jwaH-6az6A:
undetectable		 5jwaA-6az6A:
undetectable
5jwaH-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 6 ASP A  86
ARG A  89
LEU A  90
ASP A  93
 None
 0.39A 5tdzA-6az6A:
undetectable		 5tdzA-6az6A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		3 / 3 HIS A 212
GLU A 102
ASN A 167
 None
 0.94A 5wbvA-6az6A:
undetectable		 5wbvA-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		3 / 3 HIS A 212
GLU A 102
ASN A 167
 None
 0.94A 5wbvB-6az6A:
undetectable		 5wbvB-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptococcus
agalactiae) 		4 / 6 GLN A  62
VAL A  60
ALA A  53
THR A  54
 None
 0.70A 6cduB-6az6A:
2.0
6cduC-6az6A:
undetectable		 6cduB-6az6A:
undetectable
6cduC-6az6A:
undetectable