SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6azt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		3 / 3 LEU A 184
SER A 176
ASN A  73
 None
SNN  A 177 ( 3.5A)
None
 0.78A 1bx4A-6aztA:
2.9		 1bx4A-6aztA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		5 / 12 VAL A 141
LEU A 144
SER A 145
LEU A 217
TYR A 175
 None
None
None
None
SNN  A 177 ( 4.3A)
 1.00A 1pxxC-6aztA:
undetectable		 1pxxC-6aztA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		4 / 5 TYR A 316
SER A 242
HIS A 178
HIS A  76
 None
None
SNN  A 177 (-3.6A)
SNN  A 177 ( 3.3A)
 1.40A 1s19A-6aztA:
undetectable		 1s19A-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		3 / 3 ASP A 142
ASP A 196
ASN A 188
 None
 0.67A 2bm9D-6aztA:
undetectable		 2bm9D-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		6 / 12 GLY A 185
GLY A  70
ASP A 104
ASN A  73
HIS A  76
ALA A  78
 SNN  A 177 ( 3.2A)
None
None
None
SNN  A 177 ( 3.3A)
None
 1.41A 2bm9F-6aztA:
undetectable		 2bm9F-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		5 / 10 LEU A 149
LEU A 173
LEU A 197
VAL A 200
ILE A 236
 None
 1.09A 2w9gA-6aztA:
undetectable		 2w9gA-6aztA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		5 / 11 LEU A 149
LEU A 173
LEU A 197
VAL A 200
ILE A 236
 None
 1.11A 3frbX-6aztA:
undetectable		 3frbX-6aztA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		5 / 12 LEU A 271
ASP A 270
GLY A 269
TYR A 252
HIS A  82
 None
None
None
None
GOL  A 501 (-4.0A)
 1.28A 3hgiA-6aztA:
undetectable		 3hgiA-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		4 / 8 PHE A 100
VAL A  63
MET A 213
ILE A 171
 None
 0.90A 4a97C-6aztA:
undetectable		 4a97C-6aztA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		3 / 3 TYR A 237
THR A 239
GLU A 232
 None
 0.81A 4df3B-6aztA:
undetectable		 4df3B-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		5 / 12 GLY A  72
ASP A  79
HIS A  76
ASP A 270
GLY A 269
 None
None
SNN  A 177 ( 3.3A)
None
None
 1.11A 4qa2A-6aztA:
2.8		 4qa2A-6aztA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		5 / 12 VAL A  98
ILE A 171
LEU A 234
LEU A 173
ALA A 238
 None
 1.49A 5fctB-6aztA:
undetectable		 5fctB-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		5 / 12 SER A 248
GLY A 243
ALA A 244
HIS A 178
GLU A 218
 None
None
None
SNN  A 177 (-3.6A)
None
 1.36A 5wbvA-6aztA:
undetectable		 5wbvA-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		5 / 12 SER A 248
GLY A 243
ALA A 244
HIS A 178
GLU A 218
 None
None
None
SNN  A 177 (-3.6A)
None
 1.37A 5wbvB-6aztA:
undetectable		 5wbvB-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 6azt ASPARAGINYL
ENDOPEPTIDASE 1
(Helianthus
annuus) 		4 / 6 GLY A 182
ASP A 196
GLY A 179
GLY A 185
 None
None
GOL  A 503 (-3.7A)
SNN  A 177 ( 3.2A)
 0.76A 6ag0C-6aztA:
undetectable		 6ag0C-6aztA:
18.07