SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		7 / 12 VAL A  27
ALA A  40
VAL A  98
ASN A 146
LEU A 148
THR A 158
ASP A 159
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-3.1A)
CJJ  A 301 (-4.3A)
 0.71A 1fmoE-6b2qA:
26.0		 1fmoE-6b2qA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 203
VAL A 206
MET A 121
LEU A 103
HIS A  70
 None
 1.48A 1kt6A-6b2qA:
undetectable		 1kt6A-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 HIS A 117
SER A 114
LEU A 122
GLY A 207
VAL A 271
ALA A 270
 0BD  A 302 (-3.7A)
None
None
None
None
None
 1.50A 1tlsB-6b2qA:
undetectable		 1tlsB-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 HIS A 117
SER A 114
LEU A 122
GLY A 207
VAL A 271
ALA A 270
 0BD  A 302 (-3.7A)
None
None
None
None
None
 1.48A 1tsnA-6b2qA:
undetectable		 1tsnA-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 245
LEU A 248
LEU A 241
PHE A 267
ALA A 118
 None
 0.92A 2aylA-6b2qA:
undetectable		 2aylA-6b2qA:
9.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		7 / 12 VAL A  27
ALA A  40
VAL A  98
ASP A 141
LYS A 143
ASN A 146
ASP A 159
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.5A)
None
None
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.3A)
 0.78A 2fumA-6b2qA:
35.4		 2fumA-6b2qA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		7 / 12 VAL A  27
ALA A  40
MET A  95
VAL A  98
LYS A 143
ASN A 146
ASP A 159
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.6A)
CJJ  A 301 (-3.5A)
None
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.3A)
 0.70A 2fumB-6b2qA:
35.6		 2fumB-6b2qA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 113
MET A 121
LEU A 122
GLU A 209
 None
 1.28A 2kuhA-6b2qA:
0.4		 2kuhA-6b2qA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		7 / 12 VAL A  27
ALA A  40
LEU A  97
GLY A 100
LEU A 148
THR A 158
PHE A 160
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
None
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-3.1A)
None
 1.17A 3bbtB-6b2qA:
23.5		 3bbtB-6b2qA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		7 / 12 VAL A  27
ALA A  40
LYS A  42
GLY A 100
LEU A 148
THR A 158
PHE A 160
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-3.1A)
None
 1.30A 3bbtD-6b2qA:
23.8		 3bbtD-6b2qA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 245
LEU A 248
LEU A 241
PHE A 267
ALA A 118
 None
 0.93A 3kk6A-6b2qA:
undetectable		 3kk6A-6b2qA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  40
LYS A  42
GLU A  61
LEU A  97
 CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
 0.43A 3lfaA-6b2qA:
22.4		 3lfaA-6b2qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  77
ARG A  37
GLU A  96
 None
 1.15A 3qf1A-6b2qA:
undetectable		 3qf1A-6b2qA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 139
LEU A 122
LEU A 103
ASP A 120
 None
None
None
0BD  A 302 (-4.3A)
 1.30A 4aqlA-6b2qA:
undetectable		 4aqlA-6b2qA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 126
GLY A 265
PRO A 266
LEU A 203
VAL A 142
 None
 0.93A 4gc9A-6b2qA:
undetectable		 4gc9A-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  73
GLN A 130
LEU A 203
VAL A 200
ILE A 157
 None
 1.05A 4m2xG-6b2qA:
undetectable		 4m2xG-6b2qA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 134
ALA A 135
GLY A 265
GLY A 264
SER A 263
 None
 1.05A 4qvwK-6b2qA:
undetectable
4qvwL-6b2qA:
undetectable		 4qvwK-6b2qA:
19.64
4qvwL-6b2qA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 134
ALA A 135
GLY A 265
GLY A 264
SER A 263
 None
 1.05A 4qvwY-6b2qA:
undetectable
4qvwZ-6b2qA:
undetectable		 4qvwY-6b2qA:
19.64
4qvwZ-6b2qA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  56
TYR A  79
GLU A  81
 None
 0.82A 4ryaA-6b2qA:
undetectable		 4ryaA-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 10 ALA A  40
LYS A  42
THR A  65
LEU A  97
VAL A  98
LEU A 148
 CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.5A)
 0.52A 4rz7A-6b2qA:
9.9		 4rz7A-6b2qA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  19
ALA A  40
LEU A  97
VAL A  98
LEU A 148
 CJJ  A 301 (-4.1A)
CJJ  A 301 (-3.5A)
None
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.5A)
 0.67A 4rz7A-6b2qA:
9.9		 4rz7A-6b2qA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 137
PHE A 160
ASP A 159
ALA A 163
ILE A 147
 None
None
CJJ  A 301 (-4.3A)
None
None
 1.39A 4uuuA-6b2qA:
undetectable
4uuuB-6b2qA:
undetectable		 4uuuA-6b2qA:
undetectable
4uuuB-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 MET A  67
GLU A  61
ILE A 162
GLN A 188
HIS A 139
 None
 1.45A 4xucA-6b2qA:
undetectable		 4xucA-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 MET A  67
GLU A  61
ILE A 162
GLN A 188
HIS A 139
 None
 1.47A 4xudA-6b2qA:
undetectable		 4xudA-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 215
GLU A 209
GLY A 145
PRO A 144
 None
 1.00A 5kf8A-6b2qA:
undetectable		 5kf8A-6b2qA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 215
GLU A 209
GLY A 145
PRO A 144
 None
 0.98A 5kgpA-6b2qA:
undetectable		 5kgpA-6b2qA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 215
GLU A 209
GLY A 145
PRO A 144
 None
 0.94A 5kgpB-6b2qA:
undetectable		 5kgpB-6b2qA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 10 VAL A  27
ALA A  40
MET A  95
VAL A  98
LEU A 148
THR A 158
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-3.1A)
 0.78A 5n3hA-6b2qA:
25.6		 5n3hA-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		7 / 12 VAL A  27
ALA A  40
LYS A  42
GLU A  61
LEU A  97
GLY A 100
LEU A 148
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
 1.01A 5y7zA-6b2qA:
24.7		 5y7zA-6b2qA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		7 / 12 VAL A  27
ALA A  40
LYS A  42
GLU A  61
LEU A  97
GLY A 100
LEU A 148
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
 1.01A 5y7zA-6b2qA:
24.7		 5y7zA-6b2qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		8 / 12 ALA A  40
LYS A  42
GLU A  61
LEU A  93
LEU A  97
GLY A 100
LEU A 148
ASP A 159
 CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
None
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-4.3A)
 1.02A 5y7zB-6b2qA:
24.8		 5y7zB-6b2qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		8 / 12 VAL A  27
ALA A  40
LYS A  42
GLU A  61
LEU A  97
GLY A 100
LEU A 148
ASP A 159
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-4.3A)
 0.99A 5y80A-6b2qA:
24.4		 5y80A-6b2qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  68
ALA A 134
GLY A 265
ILE A  73
ILE A 131
 None
 0.94A 6dh3A-6b2qA:
undetectable		 6dh3A-6b2qA:
20.93