SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 12 SER A  32
GLU A  35
ARG A  42
ALA A  95
ILE A  96
 NA  A 401 ( 4.1A)
None
None
None
None
 1.09A 1s14B-6b2yA:
undetectable		 1s14B-6b2yA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 12 GLY A 242
GLY A 243
LYS A 244
ILE A 277
GLY A 273
 None
 1.04A 1sqfA-6b2yA:
undetectable		 1sqfA-6b2yA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 11 ARG A   9
GLY A   8
ALA A  95
VAL A  11
ILE A  13
 None
 0.94A 2nnhA-6b2yA:
undetectable		 2nnhA-6b2yA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		4 / 6 TYR A  29
TYR A 342
TYR A  61
ILE A  60
 None
None
NA  A 401 (-4.3A)
None
 1.46A 2pgzD-6b2yA:
undetectable
2pgzE-6b2yA:
undetectable		 2pgzD-6b2yA:
20.35
2pgzE-6b2yA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 12 LEU A 145
LEU A  34
SER A  32
PRO A 299
VAL A 124
 None
None
NA  A 401 ( 4.1A)
None
None
 1.10A 2qd4A-6b2yA:
undetectable		 2qd4A-6b2yA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 10 SER A 288
TYR A 238
ALA A 240
ALA A 290
TYR A 289
 None
 1.46A 2r2vC-6b2yA:
undetectable
2r2vF-6b2yA:
undetectable
2r2vG-6b2yA:
undetectable		 2r2vC-6b2yA:
6.89
2r2vF-6b2yA:
6.89
2r2vG-6b2yA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 10 LEU A 227
SER A 281
LEU A 280
ASN A 278
LEU A 231
 None
 1.12A 2xn7A-6b2yA:
undetectable
2xn7B-6b2yA:
undetectable		 2xn7A-6b2yA:
21.99
2xn7B-6b2yA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 12 PHE A  28
PHE A  50
ALA A 257
SER A 339
TYR A  61
 None
None
None
None
NA  A 401 (-4.3A)
 1.19A 3apvA-6b2yA:
undetectable		 3apvA-6b2yA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 12 PHE A  28
PHE A  50
ALA A 257
SER A 339
TYR A  61
 None
None
None
None
NA  A 401 (-4.3A)
 1.28A 3apwA-6b2yA:
undetectable		 3apwA-6b2yA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		4 / 8 GLY A  25
PHE A  97
GLY A  98
PHE A 123
 None
 1.00A 3ko0O-6b2yA:
undetectable
3ko0Q-6b2yA:
undetectable		 3ko0O-6b2yA:
14.81
3ko0Q-6b2yA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		4 / 5 VAL A 283
ILE A 239
PHE A 308
PHE A 312
 None
 0.95A 3owxB-6b2yA:
undetectable		 3owxB-6b2yA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		3 / 3 ASN A 294
TRP A 292
ASP A  49
 None
 1.11A 4a7tA-6b2yA:
undetectable
4a7tF-6b2yA:
undetectable		 4a7tA-6b2yA:
18.73
4a7tF-6b2yA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 11 TYR A 330
LEU A 334
SER A 339
TYR A 342
ALA A 257
 None
NA  A 401 ( 4.6A)
None
None
None
 1.30A 4evrA-6b2yA:
undetectable		 4evrA-6b2yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 12 GLY A 202
GLY A 199
ASP A 203
LEU A 131
ALA A 214
 None
None
None
NA  A 402 ( 4.8A)
None
 1.05A 4lg1A-6b2yA:
2.2		 4lg1A-6b2yA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 12 GLY A 202
GLY A 199
ASP A 203
LEU A 131
ALA A 214
 None
None
None
NA  A 402 ( 4.8A)
None
 1.06A 4lg1C-6b2yA:
2.1		 4lg1C-6b2yA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 12 GLN A 332
LEU A 329
GLY A  36
PHE A 157
ALA A 335
 None
 1.28A 4pclB-6b2yA:
undetectable		 4pclB-6b2yA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		4 / 5 TYR A 296
SER A 221
ASP A 125
ASP A   5
 None
 1.45A 4qtuB-6b2yA:
undetectable		 4qtuB-6b2yA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 12 VAL A   3
LEU A  27
LEU A 141
ALA A 144
PRO A 120
 None
 1.22A 5nd3B-6b2yA:
undetectable		 5nd3B-6b2yA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 11 VAL A 253
GLY A 252
ALA A 240
SER A 267
LEU A 268
 None
 1.05A 5x6yA-6b2yA:
undetectable		 5x6yA-6b2yA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 10 VAL A 253
GLY A 252
ALA A 240
SER A 267
LEU A 268
 None
 1.13A 5x6yB-6b2yA:
undetectable		 5x6yB-6b2yA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		5 / 11 VAL A 253
GLY A 252
ALA A 240
SER A 267
LEU A 268
 None
 0.87A 5x6yC-6b2yA:
undetectable		 5x6yC-6b2yA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		4 / 6 SER A 137
ARG A  26
ASP A  49
ASP A 125
 None
 0.95A 5zw4A-6b2yA:
undetectable		 5zw4A-6b2yA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER
(Yersinia
pestis) 		4 / 4 ILE A 239
LEU A 268
HIS A 287
ALA A 346
 None
 0.97A 6ck2C-6b2yA:
undetectable
6ck2D-6b2yA:
undetectable		 6ck2C-6b2yA:
4.79
6ck2D-6b2yA:
6.75