SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 7 GLN A  78
THR A  76
SER A  63
TYR A  66
 None
 1.33A 1eiiA-6b3bA:
undetectable		 1eiiA-6b3bA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		5 / 12 ALA A 457
VAL A 432
MET A 209
TYR A 206
ARG A 238
 None
GOL  A 704 ( 4.8A)
None
MLI  A 703 (-4.3A)
MLI  A 703 ( 4.8A)
 1.35A 1kt4A-6b3bA:
1.8		 1kt4A-6b3bA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		3 / 3 ALA A   9
HIS A  10
VAL A  13
 None
 0.41A 1lqtB-6b3bA:
undetectable		 1lqtB-6b3bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		3 / 3 ALA A   9
HIS A  10
VAL A  13
 None
 0.44A 1lquB-6b3bA:
undetectable		 1lquB-6b3bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 4 HIS A  10
ALA A   9
PHE A  12
GLY A  11
 None
 1.13A 1mjoB-6b3bA:
undetectable		 1mjoB-6b3bA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		5 / 12 ARG A 417
ILE A 374
PHE A 373
ILE A 406
TYR A 390
 None
 1.36A 1ot7A-6b3bA:
undetectable		 1ot7A-6b3bA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		3 / 3 SER A 447
THR A 202
GLN A 248
 None
MLI  A 703 ( 4.6A)
GOL  A 704 ( 4.7A)
 0.80A 2fk8A-6b3bA:
12.2		 2fk8A-6b3bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		6 / 12 LEU A 435
THR A 436
ASP A 467
ALA A 466
THR A 498
ILE A 497
 None
 1.45A 3a35A-6b3bA:
undetectable		 3a35A-6b3bA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		6 / 12 LEU A 435
THR A 436
ASP A 467
ALA A 466
THR A 498
ILE A 497
 None
 1.49A 3a35B-6b3bA:
undetectable		 3a35B-6b3bA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		6 / 12 LEU A 435
THR A 436
ASP A 467
ALA A 466
THR A 498
ILE A 497
 None
 1.45A 3a3bA-6b3bA:
undetectable		 3a3bA-6b3bA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 5 SER A 162
LEU A 101
GLY A 103
GLU A 166
 None
 1.10A 3aiaA-6b3bA:
1.8
3aiaB-6b3bA:
undetectable		 3aiaA-6b3bA:
16.54
3aiaB-6b3bA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 5 ILE A 559
TYR A 614
ARG A 573
GLY A 571
 None
 1.06A 3b9mA-6b3bA:
undetectable		 3b9mA-6b3bA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		5 / 12 ASP A 278
GLY A 280
LEU A 286
ASP A 315
LEU A 367
 SAM  A 701 ( 4.6A)
SAM  A 701 (-3.7A)
None
SAM  A 701 (-2.8A)
SAM  A 701 (-4.3A)
 0.90A 3cjtC-6b3bA:
11.6		 3cjtC-6b3bA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		5 / 12 LEU A 539
GLU A 550
PRO A 518
ASN A 519
LEU A 555
 None
 1.39A 3eigA-6b3bA:
undetectable		 3eigA-6b3bA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		5 / 12 ALA A 484
ILE A 263
ARG A 364
ILE A 290
LEU A 286
 None
 1.08A 3k2hB-6b3bA:
2.5		 3k2hB-6b3bA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 8 GLY A 133
ILE A 109
PHE A 156
PHE A 171
 None
 1.04A 3ko0K-6b3bA:
undetectable
3ko0S-6b3bA:
undetectable		 3ko0K-6b3bA:
9.84
3ko0S-6b3bA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		3 / 3 ARG A   7
LEU A 130
THR A 122
 None
 0.75A 3oxcA-6b3bA:
undetectable		 3oxcA-6b3bA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 7 ILE A 363
LEU A 361
THR A 256
ILE A 259
 None
 0.94A 3p50A-6b3bA:
2.1		 3p50A-6b3bA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 7 ILE A 363
LEU A 361
THR A 256
ILE A 259
 None
 0.95A 3p50B-6b3bA:
2.1		 3p50B-6b3bA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 7 ILE A 363
LEU A 361
THR A 256
ILE A 259
 None
 0.95A 3p50C-6b3bA:
undetectable		 3p50C-6b3bA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 7 ILE A 363
LEU A 361
THR A 256
ILE A 259
 None
 0.96A 3p50D-6b3bA:
2.0		 3p50D-6b3bA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 7 ILE A 363
LEU A 361
THR A 256
ILE A 259
 None
 0.98A 3p50E-6b3bA:
undetectable		 3p50E-6b3bA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		5 / 12 ALA A 512
ASP A 516
LEU A 555
ILE A 509
THR A 513
 None
 1.21A 3ql3A-6b3bA:
undetectable		 3ql3A-6b3bA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 5 GLY A 280
ASP A 278
ARG A 364
GLN A 349
 SAM  A 701 (-3.7A)
SAM  A 701 ( 4.6A)
None
None
 1.36A 3qx3A-6b3bA:
undetectable		 3qx3A-6b3bA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 5 GLY A 399
ASP A 396
ARG A 397
GLN A 461
 None
None
None
MLI  A 703 ( 2.7A)
 1.25A 3qx3B-6b3bA:
undetectable		 3qx3B-6b3bA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		5 / 12 TYR A   8
GLY A  11
GLY A 133
LEU A 136
LEU A 450
 None
 1.08A 3vywD-6b3bA:
8.1		 3vywD-6b3bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 8 SER A 420
ARG A 364
ILE A 421
GLU A 416
 None
 1.23A 4cx7A-6b3bA:
undetectable
4cx7B-6b3bA:
undetectable		 4cx7A-6b3bA:
21.87
4cx7B-6b3bA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 8 HIS A 414
GLU A 416
ARG A 364
ILE A 421
 None
 0.98A 4cx7A-6b3bA:
undetectable
4cx7B-6b3bA:
undetectable		 4cx7A-6b3bA:
21.87
4cx7B-6b3bA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 6 GLU A 231
THR A 230
THR A 239
ASN A 317
 None
None
None
SAM  A 701 (-4.9A)
 1.20A 4pfjB-6b3bA:
5.2		 4pfjB-6b3bA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		3 / 3 PRO A 208
MET A 209
TYR A 206
 None
None
MLI  A 703 (-4.3A)
 0.91A 4qa2B-6b3bA:
2.3		 4qa2B-6b3bA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		6 / 12 GLY A 280
GLY A 282
ASP A 315
ILE A 340
LEU A 286
LEU A 367
 SAM  A 701 (-3.7A)
SAM  A 701 (-3.3A)
SAM  A 701 (-2.8A)
SAM  A 701 (-4.3A)
None
SAM  A 701 (-4.3A)
 1.32A 5bw4A-6b3bA:
8.4		 5bw4A-6b3bA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 4 ASP A 278
GLY A 282
ASP A 315
ASP A 339
 SAM  A 701 ( 4.6A)
SAM  A 701 (-3.3A)
SAM  A 701 (-2.8A)
SAM  A 701 (-3.2A)
 0.48A 5e72A-6b3bA:
11.2		 5e72A-6b3bA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		3 / 3 THR A 436
PRO A 603
ASP A 467
 None
 0.91A 5l8dB-6b3bA:
undetectable		 5l8dB-6b3bA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		3 / 3 THR A 436
PRO A 603
ASP A 467
 None
 0.91A 5mwuB-6b3bA:
undetectable		 5mwuB-6b3bA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		5 / 12 GLY A 280
GLY A 282
ASP A 315
ASN A 317
LEU A 367
 SAM  A 701 (-3.7A)
SAM  A 701 (-3.3A)
SAM  A 701 (-2.8A)
SAM  A 701 (-4.9A)
SAM  A 701 (-4.3A)
 0.55A 5wy0A-6b3bA:
12.3		 5wy0A-6b3bA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 8 LEU A 143
ILE A 113
ALA A 177
LEU A 184
 None
 0.85A 5y7pC-6b3bA:
undetectable		 5y7pC-6b3bA:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		12 / 12 HIS A 249
PHE A 253
MET A 279
GLY A 280
GLY A 282
TYR A 316
ASN A 317
ALA A 320
ASP A 339
ILE A 340
LEU A 367
PRO A 372
 SAM  A 701 (-3.7A)
SAM  A 701 (-4.9A)
SAM  A 701 ( 3.9A)
SAM  A 701 (-3.7A)
SAM  A 701 (-3.3A)
SAM  A 701 (-3.5A)
SAM  A 701 (-4.9A)
SAM  A 701 (-3.6A)
SAM  A 701 (-3.2A)
SAM  A 701 (-4.3A)
SAM  A 701 (-4.3A)
SAM  A 701 (-4.5A)
 0.35A 6b3aA-6b3bA:
57.7		 6b3aA-6b3bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		12 / 12 HIS A 249
PHE A 253
MET A 279
GLY A 280
GLY A 282
TYR A 316
ASN A 317
ALA A 320
ASP A 339
ILE A 340
LEU A 367
PRO A 372
 SAM  A 701 (-3.7A)
SAM  A 701 (-4.9A)
SAM  A 701 ( 3.9A)
SAM  A 701 (-3.7A)
SAM  A 701 (-3.3A)
SAM  A 701 (-3.5A)
SAM  A 701 (-4.9A)
SAM  A 701 (-3.6A)
SAM  A 701 (-3.2A)
SAM  A 701 (-4.3A)
SAM  A 701 (-4.3A)
SAM  A 701 (-4.5A)
 0.01A 6b3bA-6b3bA:
59.7		 6b3bA-6b3bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 6b3b APRA
METHYLTRANSFERASE 1
(Moorea
bouillonii) 		4 / 4 ILE A 517
LEU A 555
HIS A 546
ALA A 558
 None
 0.99A 6ck2C-6b3bA:
undetectable
6ck2D-6b3bA:
undetectable		 6ck2C-6b3bA:
2.49
6ck2D-6b3bA:
5.18