SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 7 LEU A 243
LEU A 233
SER A 222
SER A 224
 None
 0.71A 1dvxA-6b3xA:
undetectable		 1dvxA-6b3xA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.80A 1gtfN-6b3xA:
undetectable
1gtfO-6b3xA:
undetectable		 1gtfN-6b3xA:
15.69
1gtfO-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 120
ILE A 166
PHE A 200
PHE A 181
 None
 0.87A 3ko0B-6b3xA:
undetectable
3ko0J-6b3xA:
undetectable		 3ko0B-6b3xA:
14.37
3ko0J-6b3xA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 120
ILE A 166
PHE A 200
PHE A 181
 None
 0.89A 3ko0K-6b3xA:
undetectable
3ko0S-6b3xA:
undetectable		 3ko0K-6b3xA:
14.37
3ko0S-6b3xA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		5 / 12 ASP A 372
CYH A 379
VAL A 354
ALA A 359
TRP A 381
 None
 1.25A 4iaqA-6b3xA:
undetectable		 4iaqA-6b3xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		5 / 12 ASP A 372
CYH A 379
VAL A 354
ALA A 359
TRP A 381
 None
 1.20A 4iarA-6b3xA:
undetectable		 4iarA-6b3xA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		5 / 11 ALA A 114
THR A 357
LEU A 378
VAL A 400
THR A 125
 None
 1.40A 4kyaA-6b3xA:
undetectable		 4kyaA-6b3xA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		5 / 11 ALA A 114
THR A 357
LEU A 378
VAL A 400
THR A 125
 None
 1.41A 4kyaE-6b3xA:
undetectable		 4kyaE-6b3xA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		5 / 11 ALA A 114
THR A 357
LEU A 378
VAL A 400
THR A 125
 None
 1.38A 4kyaG-6b3xA:
undetectable		 4kyaG-6b3xA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.80A 5eevL-6b3xA:
undetectable
5eevV-6b3xA:
undetectable		 5eevL-6b3xA:
15.69
5eevV-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.79A 5eewL-6b3xA:
undetectable
5eewV-6b3xA:
undetectable		 5eewL-6b3xA:
15.69
5eewV-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.80A 5eezL-6b3xA:
undetectable
5eezV-6b3xA:
undetectable		 5eezL-6b3xA:
15.69
5eezV-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.79A 5ef1L-6b3xA:
undetectable
5ef1V-6b3xA:
undetectable		 5ef1L-6b3xA:
15.69
5ef1V-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.80A 5ef2L-6b3xA:
undetectable
5ef2V-6b3xA:
undetectable		 5ef2L-6b3xA:
15.69
5ef2V-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.80A 5ef3L-6b3xA:
undetectable
5ef3V-6b3xA:
undetectable		 5ef3L-6b3xA:
15.69
5ef3V-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		4 / 5 ILE A  81
PHE A 361
TYR A 344
THR A 340
 None
 1.22A 5z84N-6b3xA:
undetectable
5z84W-6b3xA:
undetectable		 5z84N-6b3xA:
20.59
5z84W-6b3xA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1
(Homo
sapiens) 		5 / 9 ASN A 269
ILE A 123
SER A 406
GLY A 120
THR A 125
 None
 1.42A 6awpA-6b3xA:
undetectable		 6awpA-6b3xA:
21.96