SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 6b4c -
(-) 		5 / 12 GLY A 116
VAL A 107
ILE A 151
ILE A 121
PRO A  75
 None
 0.91A 1c6zB-6b4cA:
undetectable		 1c6zB-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6b4c -
(-) 		5 / 11 LEU A  60
LYS A  61
LEU A  57
LEU A  59
THR A  92
 None
 1.33A 2x7hA-6b4cA:
2.0
2x7hB-6b4cA:
undetectable		 2x7hA-6b4cA:
undetectable
2x7hB-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 6b4c -
(-) 		5 / 12 LEU A  93
LEU A  95
ALA A  53
VAL A  23
PHE A 254
 None
 0.98A 3b0wA-6b4cA:
undetectable		 3b0wA-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 6b4c -
(-) 		5 / 12 GLY A 116
VAL A 107
ILE A 151
ILE A 121
PRO A  75
 None
 0.96A 3oxcA-6b4cA:
undetectable		 3oxcA-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 6b4c -
(-) 		3 / 3 LEU A  60
MET A  65
ASP A 256
 None
 0.79A 4j7xB-6b4cA:
2.1		 4j7xB-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6b4c -
(-) 		4 / 6 VAL A 194
TYR A 292
ILE A 137
ASP A 127
 None
 1.27A 5iwuA-6b4cA:
undetectable		 5iwuA-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 6b4c -
(-) 		5 / 12 ILE A 100
PHE A  76
LEU A  77
GLY A 104
ILE A 160
 None
 1.12A 6dwnC-6b4cA:
undetectable		 6dwnC-6b4cA:
undetectable