SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6b4e NUCLEOPORIN GLE1
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 296
LEU B 353
PHE B 293
LEU B 310
ILE B 306
 None
 1.23A 2f7aB-6b4eB:
undetectable		 2f7aB-6b4eB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 6b4e NUCLEOPORIN GLE1
(Saccharomyces
cerevisiae) 		5 / 12 ASP B 390
PRO B 380
PHE B 385
ILE B 465
TYR B 512
 None
 0.94A 3clbB-6b4eB:
undetectable		 3clbB-6b4eB:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 6b4e NUCLEOPORIN GLE1
(Saccharomyces
cerevisiae) 		4 / 5 GLN B 295
GLU B 342
THR B 341
HIS B 337
 None
 1.46A 3glqB-6b4eB:
undetectable		 3glqB-6b4eB:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 6b4e NUCLEOPORIN GLE1
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 431
ALA B 426
ILE B 428
SER B 423
LEU B 424
 None
 1.24A 3gyqB-6b4eB:
undetectable		 3gyqB-6b4eB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6b4e NUCLEOPORIN GLE1
(Saccharomyces
cerevisiae) 		4 / 5 GLN B 295
GLU B 342
THR B 341
HIS B 337
 None
 1.43A 3n58A-6b4eB:
undetectable		 3n58A-6b4eB:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 6b4e NUCLEOPORIN GLE1
(Saccharomyces
cerevisiae) 		4 / 8 GLN B 295
LEU B 313
LEU B 310
ILE B 289
 None
 0.91A 3nbqC-6b4eB:
undetectable		 3nbqC-6b4eB:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 6b4e NUCLEOPORIN GLE1
(Saccharomyces
cerevisiae) 		5 / 9 ALA B 479
ASP B 478
GLY B 419
ILE B 421
LEU B 353
 None
 1.19A 3u7sB-6b4eB:
undetectable		 3u7sB-6b4eB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 6b4e NUCLEOPORIN GLE1
(Saccharomyces
cerevisiae) 		5 / 9 ALA B 479
ASP B 478
GLY B 419
ILE B 421
LEU B 353
 None
 1.13A 3u7sA-6b4eB:
undetectable		 3u7sA-6b4eB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 6b4e NUCLEOPORIN GLE1
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 381
LEU B 449
GLY B 384
PHE B 425
ALA B 426
 None
 1.13A 6c2mA-6b4eB:
undetectable		 6c2mA-6b4eB:
20.45