SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		4 / 5 LEU A 259
ILE A 274
ILE A 354
ALA A 353
 None
None
None
MES  A 604 (-2.7A)
 0.78A 2i2zA-6b4hA:
undetectable		 2i2zA-6b4hA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		4 / 4 LEU A 259
ILE A 274
ILE A 354
ALA A 353
 None
None
None
MES  A 604 (-2.7A)
 0.77A 2i30A-6b4hA:
2.1		 2i30A-6b4hA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 6b4h NUCLEOPORIN AMO1
(Chaetomium
thermophilum) 		4 / 6 ALA D 511
ASP D 512
GLU D 514
ARG D 549
 None
 1.18A 2ouzA-6b4hD:
undetectable		 2ouzA-6b4hD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		5 / 11 ILE A 330
ALA A 426
VAL A 351
ILE A 368
PHE A 375
 None
 1.14A 3b2rB-6b4hA:
undetectable		 3b2rB-6b4hA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		4 / 4 VAL A 468
ARG A 376
ILE A 330
THR A 464
 None
 1.03A 3cl9A-6b4hA:
undetectable		 3cl9A-6b4hA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		5 / 12 TYR A 484
ALA A 491
SER A 486
LEU A 492
ALA A 451
 None
 1.21A 3ou6C-6b4hA:
undetectable		 3ou6C-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		5 / 12 TYR A 484
ALA A 491
SER A 486
LEU A 492
ALA A 451
 None
 1.21A 3ou7C-6b4hA:
undetectable		 3ou7C-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		5 / 12 ILE A 330
ALA A 326
ILE A 372
PHE A 375
PHE A 445
 None
 1.22A 4cd2A-6b4hA:
undetectable		 4cd2A-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		5 / 12 ALA A 344
GLY A 421
GLY A 419
LEU A 469
LEU A 516
 None
 1.20A 4n48B-6b4hA:
undetectable		 4n48B-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		5 / 12 ALA A 266
PHE A 375
PHE A 333
GLY A 421
THR A 261
 None
 1.27A 5jlcA-6b4hA:
undetectable		 5jlcA-6b4hA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		3 / 3 ASP A 523
ASN A 475
GLN A 474
 None
 0.50A 5k7uA-6b4hA:
undetectable		 5k7uA-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		4 / 5 LEU A 367
PHE A 360
PHE A 318
LEU A 314
 None
 1.09A 5x1bP-6b4hA:
undetectable		 5x1bP-6b4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6b4h NUCLEOPORIN GLE1
(Chaetomium
thermophilum) 		3 / 3 ARG A 416
LEU A 420
PHE A 424
 None
 0.59A 6nknP-6b4hA:
2.9		 6nknP-6b4hA:
undetectable