SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		5 / 10 VAL B 464
PHE B 484
VAL B 505
VAL B 430
LEU B 451
 None
 1.11A 1fe2A-6b4jB:
undetectable		 1fe2A-6b4jB:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		3 / 3 TRP B 604
VAL B 532
PRO B 533
 None
 0.93A 1rg1A-6b4jB:
undetectable		 1rg1A-6b4jB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		3 / 3 TRP B 604
VAL B 532
PRO B 533
 None
 0.94A 1rh0A-6b4jB:
undetectable		 1rh0A-6b4jB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		4 / 5 ILE B 581
LEU B 598
ALA B 578
PHE B 641
 None
 0.85A 2opxA-6b4jB:
undetectable		 2opxA-6b4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		5 / 12 LEU B 524
ILE B 509
GLY B 508
VAL B 485
ILE B 520
 None
 0.97A 2r5pA-6b4jB:
undetectable		 2r5pA-6b4jB:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		5 / 12 LEU B 524
ILE B 509
GLY B 508
VAL B 485
ILE B 520
 None
 0.98A 2r5pC-6b4jB:
undetectable		 2r5pC-6b4jB:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		4 / 4 SER B 531
PRO B 533
PHE B 534
PRO B 529
 None
 1.36A 3bjwA-6b4jB:
undetectable		 3bjwA-6b4jB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_2
(PHOSPHOLIPASE A2)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		4 / 4 SER B 531
PRO B 533
PHE B 534
PRO B 529
 None
 1.35A 3bjwG-6b4jB:
undetectable		 3bjwG-6b4jB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		4 / 5 SER B 531
PRO B 533
PHE B 534
PRO B 529
 None
 1.38A 3bjwC-6b4jB:
undetectable		 3bjwC-6b4jB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_1
(PHOSPHOLIPASE A2)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		4 / 4 SER B 531
PRO B 533
PHE B 534
PRO B 529
 None
 1.36A 3bjwD-6b4jB:
undetectable		 3bjwD-6b4jB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 6b4j NUCLEOPORIN LIKE 2
(Homo
sapiens) 		4 / 5 LEU C 393
GLN C 400
LEU C 398
GLU C 397
 None
 1.15A 3h5gA-6b4jC:
undetectable
3h5gB-6b4jC:
undetectable		 3h5gA-6b4jC:
undetectable
3h5gB-6b4jC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 6b4j NUCLEOPORIN LIKE 2
(Homo
sapiens) 		4 / 6 LEU C 393
GLN C 400
LEU C 398
GLU C 397
 None
 1.01A 3h5gB-6b4jC:
undetectable
3h5gC-6b4jC:
undetectable		 3h5gB-6b4jC:
undetectable
3h5gC-6b4jC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		5 / 11 HIS B 449
ILE B 509
LEU B 576
PHE B 445
VAL B 430
 None
 1.19A 4fogC-6b4jB:
undetectable		 4fogC-6b4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		4 / 4 PHE B 445
HIS B 449
GLY B 508
ILE B 509
 None
 1.26A 4k50E-6b4jB:
0.8		 4k50E-6b4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		4 / 4 PHE B 445
HIS B 449
GLY B 508
ILE B 509
 None
 1.26A 4k50M-6b4jB:
0.6		 4k50M-6b4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		4 / 4 LEU B 452
SER B 450
LEU B 512
LEU B 480
 None
 1.07A 4n09A-6b4jB:
undetectable		 4n09A-6b4jB:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		3 / 3 PHE B 641
THR B 618
LEU B 675
 None
 0.73A 4qztA-6b4jB:
undetectable		 4qztA-6b4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		5 / 12 LEU B 622
PHE B 641
LEU B 645
GLY B 630
CYH B 629
 None
 1.27A 4zbrA-6b4jB:
undetectable		 4zbrA-6b4jB:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 6b4j NUCLEOPORIN GLE1
(Homo
sapiens) 		4 / 4 VAL B 492
GLU B 491
GLY B 488
LEU B 576
 None
 1.24A 5g5gC-6b4jB:
undetectable		 5g5gC-6b4jB:
undetectable