SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		5 / 12 LEU A 159
PHE A 142
PHE A 141
ILE A  51
LEU A  41
 None
None
None
None
IOD  A 403 ( 4.8A)
 1.11A 1drfA-6b4mA:
undetectable		 1drfA-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 5 GLN A 276
TRP A 128
GLU A 239
LEU A 300
 None
 1.49A 1ulvA-6b4mA:
undetectable		 1ulvA-6b4mA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		3 / 3 ASP A 290
ASP A 288
ASN A 295
 None
 0.63A 2bm9D-6b4mA:
undetectable		 2bm9D-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 7 ILE A  51
ARG A  61
PHE A 141
PHE A 150
 None
 1.13A 2q6hA-6b4mA:
0.6		 2q6hA-6b4mA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		5 / 12 LEU A 159
PHE A 142
PHE A 141
ILE A  51
LEU A  41
 None
None
None
None
IOD  A 403 ( 4.8A)
 1.12A 2w3bB-6b4mA:
undetectable		 2w3bB-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 5 VAL A 218
ILE A 248
MET A 272
ARG A 328
 None
 1.39A 3oezA-6b4mA:
undetectable		 3oezA-6b4mA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 5 VAL A 218
ILE A 248
MET A 272
ARG A 328
 None
 1.48A 3pyyB-6b4mA:
undetectable		 3pyyB-6b4mA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 6 ARG A 231
TYR A 169
PHE A  56
PRO A 162
 None
 1.35A 3tgvB-6b4mA:
undetectable		 3tgvB-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 5 ARG A 231
TYR A 169
PHE A  56
PRO A 162
 None
 1.34A 3tgvC-6b4mA:
undetectable		 3tgvC-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		5 / 12 VAL A 335
ALA A 331
LEU A 350
PHE A 253
LEU A 300
 None
 1.13A 4eckA-6b4mA:
undetectable		 4eckA-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		5 / 12 LEU A 159
PHE A 142
PHE A 141
ILE A  51
LEU A  41
 None
None
None
None
IOD  A 403 ( 4.8A)
 1.10A 4kebB-6b4mA:
undetectable		 4kebB-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		5 / 12 LEU A 159
PHE A 142
PHE A 141
ILE A  51
LEU A  41
 None
None
None
None
IOD  A 403 ( 4.8A)
 1.10A 4m6kA-6b4mA:
undetectable		 4m6kA-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 4 ALA A 140
ALA A 143
ALA A 144
ALA A 147
 None
 0.10A 4oadA-6b4mA:
undetectable		 4oadA-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 4 ALA A 140
ALA A 143
ALA A 144
ALA A 147
 None
 0.07A 4oaeA-6b4mA:
undetectable		 4oaeA-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		5 / 9 THR A  84
PHE A 262
ILE A 263
PHE A  30
GLY A  29
 None
 1.32A 4ze0A-6b4mA:
undetectable		 4ze0A-6b4mA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 8 ALA A  20
PRO A  31
LEU A  33
LEU A  62
 None
 1.01A 5dzkd-6b4mA:
undetectable
5dzkr-6b4mA:
undetectable		 5dzkd-6b4mA:
undetectable
5dzkr-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 8 ALA A  20
PRO A  31
LEU A  33
LEU A  62
 None
 0.76A 5dzkF-6b4mA:
undetectable
5dzkT-6b4mA:
undetectable		 5dzkF-6b4mA:
undetectable
5dzkT-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		3 / 3 VAL A 153
GLU A 174
GLU A 173
 GOL  A 404 (-4.7A)
None
None
 0.95A 5jsdB-6b4mA:
undetectable
5jsdC-6b4mA:
undetectable		 5jsdB-6b4mA:
8.12
5jsdC-6b4mA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 5 ASN A  45
ASP A  60
ASN A  57
ASP A 119
 None
 1.43A 5vooA-6b4mA:
undetectable		 5vooA-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 5 ASN A  45
ASP A  60
ASN A  57
ASP A 119
 None
 1.41A 5vooC-6b4mA:
2.5		 5vooC-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 5 ASN A  45
ASP A  60
ASN A  57
ASP A 119
 None
 1.46A 5vooE-6b4mA:
2.4		 5vooE-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 7 ARG A 278
GLU A 239
ARG A 275
PRO A 273
 None
 1.42A 6a4iB-6b4mA:
1.6		 6a4iB-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 8 ILE A  98
TRP A 129
ARG A  61
TRP A 128
 None
 1.19A 6hisA-6b4mA:
undetectable
6hisB-6b4mA:
undetectable		 6hisA-6b4mA:
22.62
6hisB-6b4mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 8 ILE A  98
TRP A 129
ARG A  61
TRP A 128
 None
 1.18A 6hisB-6b4mA:
undetectable
6hisC-6b4mA:
undetectable		 6hisB-6b4mA:
22.62
6hisC-6b4mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 8 ILE A  98
TRP A 129
ARG A  61
TRP A 128
 None
 1.18A 6hisC-6b4mA:
undetectable
6hisD-6b4mA:
undetectable		 6hisC-6b4mA:
22.62
6hisD-6b4mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 8 ILE A  98
TRP A 129
ARG A  61
TRP A 128
 None
 1.19A 6hisD-6b4mA:
undetectable
6hisE-6b4mA:
undetectable		 6hisD-6b4mA:
22.62
6hisE-6b4mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		4 / 8 TRP A 128
ILE A  98
TRP A 129
ARG A  61
 None
 1.18A 6hisA-6b4mA:
undetectable
6hisE-6b4mA:
undetectable		 6hisA-6b4mA:
22.62
6hisE-6b4mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 6b4m MONOTREME LACTATION
PROTEIN
(Ornithorhynchus
anatinus) 		5 / 12 VAL A 269
TYR A  58
THR A  92
PHE A 262
PHE A  30
 None
 1.41A 6j20A-6b4mA:
undetectable		 6j20A-6b4mA:
undetectable