SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 7 LEU A 181
ILE A 407
THR A 344
MET A 220
 None
 1.28A 1kglA-6b4oA:
undetectable		 1kglA-6b4oA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 GLY A  45
GLY A 140
GLY A 139
ASP A 302
ARG A 262
 FAD  A 501 (-3.6A)
None
FAD  A 501 (-3.3A)
FAD  A 501 (-2.9A)
FAD  A 501 (-3.9A)
 1.08A 1mxgA-6b4oA:
undetectable		 1mxgA-6b4oA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 8 MET A 222
THR A 192
ALA A 190
VAL A 169
 None
 0.54A 1sn5C-6b4oA:
undetectable		 1sn5C-6b4oA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 9 LEU A 135
ILE A 297
PHE A 116
VAL A 284
ALA A 137
 None
None
None
None
FAD  A 501 (-4.8A)
 1.04A 2m9qA-6b4oA:
undetectable		 2m9qA-6b4oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 GLY A  11
ALA A 137
GLY A 139
LEU A 135
LEU A 102
 FAD  A 501 ( 4.9A)
FAD  A 501 (-4.8A)
FAD  A 501 (-3.3A)
None
None
 1.06A 2nyuB-6b4oA:
undetectable		 2nyuB-6b4oA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 4 ALA A 114
VAL A   8
PHE A 116
THR A 138
 FAD  A 501 (-4.0A)
None
None
FAD  A 501 (-3.9A)
 1.48A 2pkkA-6b4oA:
undetectable		 2pkkA-6b4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 8 TYR A 298
LEU A 135
LEU A 320
ALA A  22
 None
 1.09A 2wekA-6b4oA:
3.2		 2wekA-6b4oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 8 ILE A 134
TYR A   4
VAL A   8
TYR A 129
 None
 1.30A 2xz5C-6b4oA:
undetectable
2xz5D-6b4oA:
undetectable		 2xz5C-6b4oA:
19.29
2xz5D-6b4oA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 7 ILE A 134
TYR A   4
VAL A   8
TYR A 129
 None
 1.31A 2xz5D-6b4oA:
undetectable
2xz5E-6b4oA:
undetectable		 2xz5D-6b4oA:
19.29
2xz5E-6b4oA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 8 ARG A 323
PHE A 325
PRO A 132
GLY A 296
 None
 0.87A 2y6rB-6b4oA:
4.2		 2y6rB-6b4oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 GLY A  11
GLY A  39
ASN A  20
ALA A  19
GLU A  36
 FAD  A 501 ( 4.9A)
FAD  A 501 (-3.3A)
CL  A 504 (-4.2A)
None
MG  A 502 ( 4.1A)
 1.13A 3ckkA-6b4oA:
undetectable		 3ckkA-6b4oA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		3 / 3 ASN A 227
MET A 222
PHE A 196
 None
 1.07A 3g4lD-6b4oA:
undetectable		 3g4lD-6b4oA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 9 LEU A 324
ALA A  27
ILE A 107
ILE A   7
LEU A 320
 None
 0.97A 3u7sA-6b4oA:
undetectable		 3u7sA-6b4oA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 5 THR A 138
GLY A 140
PRO A 264
ASN A 265
 FAD  A 501 (-3.9A)
None
None
FAD  A 501 ( 4.8A)
 0.76A 3u8qA-6b4oA:
undetectable		 3u8qA-6b4oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 LEU A  94
TYR A  98
ILE A  16
GLY A  39
ILE A  37
 None
None
None
FAD  A 501 (-3.3A)
None
 1.03A 3uj6A-6b4oA:
3.0		 3uj6A-6b4oA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 6 MET A 414
PRO A 346
GLN A 386
PRO A 376
 None
 1.33A 3vkxA-6b4oA:
undetectable		 3vkxA-6b4oA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 6 THR A 138
GLY A 140
PRO A 264
ASN A 265
 FAD  A 501 (-3.9A)
None
None
FAD  A 501 ( 4.8A)
 0.74A 4fjpA-6b4oA:
undetectable		 4fjpA-6b4oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		3 / 3 GLU A 322
ARG A  21
HIS A  25
 None
 0.73A 4kf9A-6b4oA:
undetectable		 4kf9A-6b4oA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 PHE A 116
LEU A 269
GLY A 270
ILE A  37
LEU A 102
 None
 1.05A 4kt0A-6b4oA:
undetectable
4kt0J-6b4oA:
undetectable		 4kt0A-6b4oA:
20.87
4kt0J-6b4oA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ASN A  99
GLY A  12
ILE A 314
GLY A 317
ASN A  20
 None
FAD  A 501 (-3.3A)
None
None
CL  A 504 (-4.2A)
 1.25A 4obwA-6b4oA:
2.1		 4obwA-6b4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ASN A  99
GLY A  12
GLY A  38
ILE A 314
GLY A 317
ASN A  20
 None
FAD  A 501 (-3.3A)
None
None
None
CL  A 504 (-4.2A)
 1.27A 4obwB-6b4oA:
undetectable		 4obwB-6b4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ASN A  99
GLY A  12
ILE A 314
GLY A 317
ASN A  20
 None
FAD  A 501 (-3.3A)
None
None
CL  A 504 (-4.2A)
 1.25A 4obwC-6b4oA:
undetectable		 4obwC-6b4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 GLY A 317
GLN A 290
LEU A 135
VAL A 303
ILE A  16
 None
 1.26A 4okbA-6b4oA:
undetectable		 4okbA-6b4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		4 / 5 LEU A 135
PHE A 116
ILE A   7
ILE A 122
 None
 1.05A 5dzk4-6b4oA:
undetectable
5dzkg-6b4oA:
undetectable
5dzkm-6b4oA:
undetectable
5dzkn-6b4oA:
undetectable		 5dzk4-6b4oA:
5.88
5dzkg-6b4oA:
18.95
5dzkm-6b4oA:
18.38
5dzkn-6b4oA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 9 GLY A 139
VAL A 303
ALA A 299
LEU A 135
LEU A 269
 FAD  A 501 (-3.3A)
None
None
None
None
 0.97A 5lw1H-6b4oA:
undetectable		 5lw1H-6b4oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 GLY A  10
GLY A  12
GLU A  33
THR A 138
ASN A 265
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.3A)
FAD  A 501 (-2.6A)
FAD  A 501 (-3.9A)
FAD  A 501 ( 4.8A)
 0.82A 6exiA-6b4oA:
3.6		 6exiA-6b4oA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 GLY A  10
GLY A  12
GLU A  33
THR A 138
ASN A 265
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.3A)
FAD  A 501 (-2.6A)
FAD  A 501 (-3.9A)
FAD  A 501 ( 4.8A)
 0.85A 6exiB-6b4oA:
3.6		 6exiB-6b4oA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 GLY A  10
GLY A  12
GLU A  33
THR A 138
ASN A 265
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.3A)
FAD  A 501 (-2.6A)
FAD  A 501 (-3.9A)
FAD  A 501 ( 4.8A)
 0.84A 6exiC-6b4oA:
2.6
6exiD-6b4oA:
3.1		 6exiC-6b4oA:
13.04
6exiD-6b4oA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 GLY A  10
GLY A  12
GLU A  33
THR A 138
ASN A 265
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.3A)
FAD  A 501 (-2.6A)
FAD  A 501 (-3.9A)
FAD  A 501 ( 4.8A)
 0.83A 6exiC-6b4oA:
3.1
6exiD-6b4oA:
3.1		 6exiC-6b4oA:
13.04
6exiD-6b4oA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 6b4o GLUTATHIONE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 VAL A 124
PHE A 116
ILE A 122
VAL A   8
ILE A   7
 None
 1.44A 6gsdA-6b4oA:
6.4		 6gsdA-6b4oA:
11.86