SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		4 / 8 VAL A 313
LEU A 297
SER A 258
VAL A 257
 None
 1.04A 1jtvA-6b5dA:
undetectable		 1jtvA-6b5dA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		4 / 7 PHE A 290
ALA A 338
ILE A 242
ILE A 357
 None
 0.71A 1oniD-6b5dA:
undetectable
1oniF-6b5dA:
undetectable		 1oniD-6b5dA:
undetectable
1oniF-6b5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 318
LEU A 349
ALA A 337
VAL A 335
ALA A 228
 None
 1.08A 1sa1A-6b5dA:
undetectable
1sa1B-6b5dA:
undetectable		 1sa1A-6b5dA:
12.13
1sa1B-6b5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		4 / 8 TYR A 386
ARG A 367
ILE A 371
ASP A 387
 None
 1.08A 2xytE-6b5dA:
undetectable		 2xytE-6b5dA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		4 / 8 TYR A 386
ARG A 367
ILE A 371
ASP A 387
 None
 1.07A 2xytH-6b5dA:
undetectable		 2xytH-6b5dA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		5 / 9 LEU A 205
ILE A 359
ALA A 232
THR A 339
ALA A 337
 None
 1.32A 3mdtA-6b5dA:
undetectable		 3mdtA-6b5dA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		3 / 3 LYS A 227
PRO A 225
LYS A 332
 None
 1.19A 4dr5L-6b5dA:
undetectable		 4dr5L-6b5dA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		3 / 3 LYS A 227
PRO A 225
LYS A 332
 None
 1.18A 4dr6L-6b5dA:
undetectable		 4dr6L-6b5dA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		3 / 3 LYS A 227
PRO A 225
LYS A 332
 None
 1.29A 4duzL-6b5dA:
undetectable		 4duzL-6b5dA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 318
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 0.73A 4x1kD-6b5dA:
undetectable		 4x1kD-6b5dA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		5 / 12 THR A 339
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 0.87A 4x1kD-6b5dA:
undetectable		 4x1kD-6b5dA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 318
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 0.75A 4x1yD-6b5dA:
undetectable		 4x1yD-6b5dA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		5 / 12 THR A 339
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 0.90A 4x1yD-6b5dA:
undetectable		 4x1yD-6b5dA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 318
LEU A 349
ALA A 337
VAL A 335
ALA A 228
 None
 0.95A 4x20B-6b5dA:
undetectable		 4x20B-6b5dA:
11.16