SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  68
VAL A  73
LEU A  38
LEU A  51
TYR A  77
 None
 1.13A 1pbcA-6b5eA:
undetectable		 1pbcA-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 7 THR A 223
TYR A 173
PHE A 111
LEU A  86
 None
None
None
DAU  A 301 (-4.8A)
 1.12A 2hzqA-6b5eA:
undetectable		 2hzqA-6b5eA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 209
ARG A 208
VAL A 202
GLN A 206
ASP A 176
 None
 1.14A 2q6hA-6b5eA:
undetectable		 2q6hA-6b5eA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 0.95A 3eeyA-6b5eA:
undetectable		 3eeyA-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 0.96A 3eeyB-6b5eA:
undetectable		 3eeyB-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 0.98A 3eeyC-6b5eA:
undetectable		 3eeyC-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 1.03A 3eeyD-6b5eA:
undetectable		 3eeyD-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 0.93A 3eeyE-6b5eA:
undetectable		 3eeyE-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 0.92A 3eeyF-6b5eA:
undetectable		 3eeyF-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 108
ILE A  49
ASN A 109
LEU A 104
THR A  40
 MG  A 302 ( 2.5A)
None
DAU  A 301 (-3.2A)
None
None
 1.00A 3eeyJ-6b5eA:
undetectable		 3eeyJ-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  45
ALA A  44
VAL A 105
GLY A   3
ILE A 126
 None
 1.12A 3s56A-6b5eA:
undetectable		 3s56A-6b5eA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 171
LEU A  41
ASP A 108
LEU A 106
ILE A   5
 DAU  A 301 ( 4.3A)
None
MG  A 302 ( 2.5A)
DAU  A 301 (-3.9A)
None
 1.16A 3wdmB-6b5eA:
undetectable		 3wdmB-6b5eA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 171
LEU A  41
ASP A 108
LEU A 106
ILE A   5
 DAU  A 301 ( 4.3A)
None
MG  A 302 ( 2.5A)
DAU  A 301 (-3.9A)
None
 1.12A 3wdmD-6b5eA:
undetectable		 3wdmD-6b5eA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 104
ILE A   4
ILE A   5
TYR A  35
ILE A  52
 None
 0.97A 3zosA-6b5eA:
undetectable		 3zosA-6b5eA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 281
ILE A 249
ASP A  30
GLY A 276
LEU A 272
 None
 0.85A 4lmnA-6b5eA:
undetectable		 4lmnA-6b5eA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		5 / 12 SER A 165
SER A 155
GLU A 195
TYR A 142
GLY A 143
 None
None
None
None
DAU  A 301 (-3.4A)
 1.29A 4qb9E-6b5eA:
undetectable		 4qb9E-6b5eA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 5 ALA A  58
TYR A  77
GLY A 278
LEU A  71
 EDO  A 305 (-3.6A)
None
None
None
 0.95A 5eslA-6b5eA:
undetectable		 5eslA-6b5eA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 269
PRO A 250
GLY A   3
LEU A  65
 None
 0.97A 5eslA-6b5eA:
undetectable		 5eslA-6b5eA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EUM_B_ACTB603_0
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Mycobacterium
tuberculosis) 		4 / 4 ALA A  94
ASN A  95
ARG A 184
ILE A 180
 None
 1.22A 5eumB-6b5eA:
undetectable		 5eumB-6b5eA:
undetectable