SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 6 PHE A 404
ILE A 425
ALA A 383
MET A 411
 None
 1.17A 1hk2A-6b5iA:
undetectable		 1hk2A-6b5iA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK4_A_T44A1008_1
(SERUM ALBUMIN)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 10 ASP A 453
LYS A 456
ALA A 457
GLU A 329
VAL A 449
 None
 1.49A 1hk4A-6b5iA:
0.0		 1hk4A-6b5iA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 10 ASP A 453
LYS A 456
ALA A 457
GLU A 329
VAL A 449
 None
 1.46A 1hk5A-6b5iA:
undetectable		 1hk5A-6b5iA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 4 HIS A 253
ASP A  73
SER A  49
ASP A  78
 None
 1.43A 1n2xA-6b5iA:
4.1		 1n2xA-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 11 GLY A 241
ALA A  72
ILE A  42
ILE A 209
ILE A  77
 None
 0.93A 1n49B-6b5iA:
undetectable		 1n49B-6b5iA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 11 GLY A 241
ALA A  72
ILE A  42
ILE A 209
ILE A  77
 None
 0.93A 1n49C-6b5iA:
undetectable		 1n49C-6b5iA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 10 LEU A 109
ALA A 200
ALA A 198
VAL A 113
LEU A 190
PHE A 231
 None
 1.46A 1rlbE-6b5iA:
undetectable		 1rlbE-6b5iA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 SER A 291
ALA A 466
GLY A 467
LEU A 445
PHE A 483
 None
None
None
None
CU4  A 601 (-4.2A)
 1.22A 1vpoH-6b5iA:
undetectable
1vpoL-6b5iA:
undetectable		 1vpoH-6b5iA:
13.49
1vpoL-6b5iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 GLN A 310
HIS A 309
ARG A 346
 CU4  A 601 (-3.6A)
None
None
 1.09A 1zlqA-6b5iA:
undetectable		 1zlqA-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 9 GLN A 318
GLY A 129
GLU A 124
ASN A 127
ALA A  61
 None
 1.10A 2drdA-6b5iA:
undetectable		 2drdA-6b5iA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 MET A 123
ILE A 197
LEU A 109
GLY A 223
ILE A 238
 None
 1.26A 2e7fA-6b5iA:
undetectable		 2e7fA-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 MET A 123
ILE A 197
LEU A 109
GLY A 223
ILE A 238
 None
 1.21A 2e7fB-6b5iA:
undetectable		 2e7fB-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 11 GLY A 247
ALA A 246
ILE A  40
ILE A 209
VAL A  81
ILE A  77
 None
 1.10A 2fxeB-6b5iA:
undetectable		 2fxeB-6b5iA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 6 SER A 441
SER A 291
LEU A 445
GLY A 289
 None
 0.98A 2j2pA-6b5iA:
undetectable
2j2pC-6b5iA:
undetectable		 2j2pA-6b5iA:
15.67
2j2pC-6b5iA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 6 SER A 441
SER A 489
LEU A 445
GLY A 444
 None
 0.96A 2j2pA-6b5iA:
undetectable
2j2pC-6b5iA:
undetectable		 2j2pA-6b5iA:
15.67
2j2pC-6b5iA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 6 SER A 441
SER A 291
LEU A 445
GLY A 289
 None
 1.00A 2j2pD-6b5iA:
undetectable
2j2pF-6b5iA:
undetectable		 2j2pD-6b5iA:
15.67
2j2pF-6b5iA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 6 SER A 441
SER A 489
LEU A 445
GLY A 444
 None
 0.95A 2j2pD-6b5iA:
undetectable
2j2pF-6b5iA:
undetectable		 2j2pD-6b5iA:
15.67
2j2pF-6b5iA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 5 VAL A 446
SER A 324
VAL A 312
SER A 291
 None
 1.37A 2j9cA-6b5iA:
undetectable
2j9cB-6b5iA:
undetectable
2j9cC-6b5iA:
undetectable		 2j9cA-6b5iA:
undetectable
2j9cB-6b5iA:
undetectable
2j9cC-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 MET A 123
ILE A 197
LEU A 109
GLY A 223
ILE A 238
 None
 1.28A 2ogyA-6b5iA:
undetectable		 2ogyA-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 MET A 123
ILE A 197
LEU A 109
GLY A 223
ILE A 238
 None
 1.21A 2ogyB-6b5iA:
undetectable		 2ogyB-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 GLY A 444
LEU A 445
PRO A 482
ALA A 466
VAL A 446
 None
 1.03A 3av6A-6b5iA:
2.2		 3av6A-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 LEU A 239
PRO A 176
VAL A 208
PRO A 233
PRO A 232
 None
 1.27A 3dcjA-6b5iA:
2.6
3dcjB-6b5iA:
2.7		 3dcjA-6b5iA:
undetectable
3dcjB-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 7 ASN A 205
TYR A 503
ARG A 102
ALA A 198
 None
 1.36A 3frqB-6b5iA:
undetectable		 3frqB-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 ALA A 249
GLY A 181
ILE A 259
ALA A 274
ILE A 256
 None
 1.04A 3n3iA-6b5iA:
undetectable		 3n3iA-6b5iA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 9 ALA A 246
ILE A  40
ILE A 209
VAL A  81
ILE A  77
 None
 1.00A 3ndwB-6b5iA:
undetectable		 3ndwB-6b5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 11 GLY A 247
ALA A 246
ILE A  40
ILE A 209
VAL A  81
ILE A  77
 None
 1.02A 3ndxB-6b5iA:
undetectable		 3ndxB-6b5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 5 ASN A 279
GLU A 494
THR A 262
SER A 278
 None
 1.36A 3p2kC-6b5iA:
4.6		 3p2kC-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 GLY A 129
ASP A 364
ILE A 363
GLY A 360
PHE A 398
 None
 1.15A 3ps9A-6b5iA:
undetectable		 3ps9A-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 5 VAL A 407
ILE A 326
MET A 464
ARG A 412
 None
 1.35A 3pyyB-6b5iA:
undetectable		 3pyyB-6b5iA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 7 GLU A 286
THR A 468
VAL A 446
LEU A 445
 None
 1.03A 3uniA-6b5iA:
undetectable		 3uniA-6b5iA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 ARG A 102
ARG A  95
TRP A  94
 None
 1.26A 4b7nA-6b5iA:
undetectable		 4b7nA-6b5iA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 ARG A 102
ARG A  95
TRP A  94
 None
 1.33A 4cpzC-6b5iA:
undetectable		 4cpzC-6b5iA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 ARG A 102
ARG A  95
TRP A  94
 None
 1.23A 4cpzE-6b5iA:
undetectable		 4cpzE-6b5iA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 ARG A 102
ARG A  95
TRP A  94
 None
 1.29A 4cpzF-6b5iA:
undetectable		 4cpzF-6b5iA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 ARG A 102
ARG A  95
TRP A  94
 None
 1.24A 4cpzG-6b5iA:
undetectable		 4cpzG-6b5iA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 ARG A 102
ARG A  95
TRP A  94
 None
 1.33A 4cpzH-6b5iA:
undetectable		 4cpzH-6b5iA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 11 GLY A 396
PRO A 421
ILE A 371
LEU A 372
ILE A 399
 None
 1.01A 4dt8A-6b5iA:
undetectable		 4dt8A-6b5iA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 10 GLY A 396
PRO A 421
ILE A 371
LEU A 372
ILE A 399
 None
 0.92A 4dt8B-6b5iA:
undetectable		 4dt8B-6b5iA:
12.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 11 ASN A 187
PHE A 188
LEU A 191
MET A 192
TRP A 195
CYH A 320
 CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
None
CU4  A 601 ( 4.7A)
CU4  A 601 (-4.2A)
CU4  A 601 (-4.2A)
 0.62A 4fr8A-6b5iA:
65.0		 4fr8A-6b5iA:
55.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 ASN A 205
ALA A 260
GLY A 181
ASP A 257
ILE A 184
 None
 1.04A 4obwB-6b5iA:
3.8		 4obwB-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 GLY A 360
PRO A 361
GLN A 318
 None
 0.27A 4oltB-6b5iA:
undetectable		 4oltB-6b5iA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 11 ILE A 184
PHE A 193
ILE A 226
ILE A 209
THR A 215
 None
 1.37A 4p68A-6b5iA:
undetectable		 4p68A-6b5iA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 GLY A 360
PRO A 361
GLN A 318
 None
 0.20A 4qwpB-6b5iA:
undetectable		 4qwpB-6b5iA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		9 / 12 GLY A 142
THR A 146
ASN A 187
PHE A 188
LEU A 191
MET A 192
CYH A 319
CYH A 320
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
None
CU4  A 601 ( 4.7A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.0A)
 0.78A 5fhzA-6b5iA:
62.8		 5fhzA-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		9 / 12 GLY A 142
THR A 146
ASN A 187
PHE A 188
LEU A 191
MET A 192
TRP A 195
CYH A 319
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
None
CU4  A 601 ( 4.7A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-3.0A)
 0.71A 5fhzA-6b5iA:
62.8		 5fhzA-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 12 GLY A 142
THR A 146
ASN A 315
LEU A 191
TRP A 195
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
None
None
CU4  A 601 (-4.2A)
CU4  A 601 (-3.0A)
 1.46A 5fhzA-6b5iA:
62.8		 5fhzA-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		7 / 9 GLY A 142
THR A 146
LEU A 191
TRP A 195
GLN A 310
ASN A 475
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
None
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
CU4  A 601 (-3.7A)
CU4  A 601 (-3.8A)
 0.71A 5fhzB-6b5iA:
59.6		 5fhzB-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 9 GLY A 142
THR A 146
TRP A 195
GLN A 307
ASN A 475
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
CU4  A 601 (-4.2A)
None
CU4  A 601 (-3.7A)
CU4  A 601 (-3.8A)
 1.43A 5fhzB-6b5iA:
59.6		 5fhzB-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		8 / 10 GLY A 142
THR A 146
LEU A 191
TRP A 195
GLN A 310
PHE A 314
ASN A 475
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
None
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
CU4  A 601 (-3.7A)
CU4  A 601 (-3.7A)
CU4  A 601 (-3.8A)
 0.66A 5fhzC-6b5iA:
62.4		 5fhzC-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 12 GLY A 142
ASN A 187
MET A 192
CYH A 319
CYH A 320
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.7A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.0A)
 0.96A 5fhzD-6b5iA:
61.8		 5fhzD-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		7 / 12 GLY A 142
ASN A 187
MET A 192
TRP A 195
CYH A 319
THR A 321
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.7A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-3.0A)
CU4  A 601 (-3.8A)
 0.79A 5fhzD-6b5iA:
61.8		 5fhzD-6b5iA:
63.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 GLY A 128
GLY A 129
GLN A 318
 None
 0.32A 5imsA-6b5iA:
2.5		 5imsA-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 9 ALA A 246
ILE A  40
ILE A 209
VAL A  81
ILE A  77
 None
 1.09A 5kr0A-6b5iA:
undetectable		 5kr0A-6b5iA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 ARG A 117
ARG A 148
ARG A 115
 None
 0.82A 5vcgA-6b5iA:
undetectable		 5vcgA-6b5iA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 8 GLN A  47
ILE A 236
ALA A  84
VAL A  81
 None
 0.94A 6hu9a-6b5iA:
undetectable
6hu9e-6b5iA:
undetectable		 6hu9a-6b5iA:
undetectable
6hu9e-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		4 / 6 ILE A 157
LEU A 500
ARG A  95
THR A 206
 None
 1.13A 6nmfN-6b5iA:
undetectable
6nmfW-6b5iA:
undetectable		 6nmfN-6b5iA:
undetectable
6nmfW-6b5iA:
undetectable