SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 6b6m CYANATE HYDRATASE
(Serratia
proteamaculans) 		5 / 12 ALA A  57
THR A   2
ILE A  78
PRO A  79
THR A  36
 None
 1.06A 1dhfA-6b6mA:
undetectable		 1dhfA-6b6mA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 6b6m CYANATE HYDRATASE
(Serratia
proteamaculans) 		4 / 4 ARG A  59
ALA A  58
ALA A  71
GLU A  69
 None
 1.06A 1e7bA-6b6mA:
undetectable		 1e7bA-6b6mA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 6b6m CYANATE HYDRATASE
(Serratia
proteamaculans) 		4 / 4 ARG A  59
ALA A  58
ALA A  71
GLU A  69
 None
 1.08A 1e7bB-6b6mA:
undetectable		 1e7bB-6b6mA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 6b6m CYANATE HYDRATASE
(Serratia
proteamaculans) 		5 / 11 ALA A  57
THR A   2
ILE A  78
PRO A  79
THR A  36
 None
 1.20A 2w3aA-6b6mA:
undetectable		 2w3aA-6b6mA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6b6m CYANATE HYDRATASE
(Serratia
proteamaculans) 		5 / 12 ALA A  57
THR A   2
ILE A  78
PRO A  79
THR A  36
 None
 1.18A 3nrrA-6b6mA:
undetectable		 3nrrA-6b6mA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 6b6m CYANATE HYDRATASE
(Serratia
proteamaculans) 		5 / 9 ARG A  81
PHE A 126
THR A 145
ASP A 129
PHE A  42
 None
 1.47A 4drhB-6b6mA:
0.0		 4drhB-6b6mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 6b6m CYANATE HYDRATASE
(Serratia
proteamaculans) 		5 / 9 ARG A  81
PHE A 126
THR A 145
ASP A 129
PHE A  42
 None
 1.48A 4drhE-6b6mA:
0.0		 4drhE-6b6mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 6b6m CYANATE HYDRATASE
(Serratia
proteamaculans) 		4 / 7 ILE A 121
ASP A 118
GLY A 117
PHE A 116
 None
 0.85A 5h3aB-6b6mA:
undetectable		 5h3aB-6b6mA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 6b6m CYANATE HYDRATASE
(Serratia
proteamaculans) 		3 / 3 LYS A 127
ASP A 129
ILE A 121
 None
 0.64A 5kc4E-6b6mA:
undetectable		 5kc4E-6b6mA:
21.47