SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b73'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNJ_A_225A501_1 (CYTOCHROME P450 2C8)	6b73	SOLUBLE CYTOCHROME B562, KAPPA-TYPE OPIOID RECEPTOR (Escherichia coli; Homo sapiens)	5 / 10	LEU A 149 VAL A 282 ALA A 281 ILE A 242 VAL A 239	None	1.05A	2nnjA-6b73A: undetectable	2nnjA-6b73A: 11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OKC_A_SAMA500_0 (TYPE I RESTRICTION ENZYME STYSJI M PROTEIN)	6b73	SOLUBLE CYTOCHROME B562, KAPPA-TYPE OPIOID RECEPTOR (Escherichia coli; Homo sapiens)	5 / 12	TYR A 320 ALA A 104 GLY A 76 THR A 111 ASN A 326	CVV A2001 (-3.8A) None None CVV A2001 ( 4.3A) None	1.13A	2okcA-6b73A: undetectable	2okcA-6b73A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACB_C_DXCC1478_0 (TRANSLATION ELONGATION FACTOR SELB)	6b73	SOLUBLE CYTOCHROME B562, KAPPA-TYPE OPIOID RECEPTOR (Escherichia coli; Homo sapiens)	4 / 6	SER A 123 THR A 199 ILE A 208 THR A 117	None	1.01A	4acbC-6b73A: undetectable	4acbC-6b73A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA0_B_SHHB404_2 (HISTONE DEACETYLASE 8)	6b73	SOLUBLE CYTOCHROME B562, KAPPA-TYPE OPIOID RECEPTOR (Escherichia coli; Homo sapiens)	5 / 11	PHE A 283 HIS A 291 PHE A 235 MET A 142 GLY A 319	None CVV A2001 ( 4.5A) None CVV A2001 (-3.6A) CVV A2001 (-3.7A)	1.36A	4qa0B-6b73A: undetectable	4qa0B-6b73A: 13.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2NNJ_A_225A501_1","CYTOCHROME P450 2C8","6b73","SOLUBLE CYTOCHROME B562, KAPPA-TYPE OPIOID RECEPTOR","Escherichia coli;Homo sapiens",5,"LEU A 149;VAL A 282;ALA A 281;ILE A 242;VAL A 239","None","1.05A","2nnjA-6b73A:undetectable","2nnjA-6b73A:11.26"],["2OKC_A_SAMA500_0","TYPE I RESTRICTION ENZYME STYSJI M PROTEIN","6b73","SOLUBLE CYTOCHROME B562, KAPPA-TYPE OPIOID RECEPTOR","Escherichia coli;Homo sapiens",5,"TYR A 320;ALA A 104;GLY A  76;THR A 111;ASN A 326","CVV A2001 (-3.8A);None;None;CVV A2001 ( 4.3A);None","1.13A","2okcA-6b73A:undetectable","2okcA-6b73A:undetectable"],["4ACB_C_DXCC1478_0","TRANSLATION ELONGATION FACTOR SELB","6b73","SOLUBLE CYTOCHROME B562, KAPPA-TYPE OPIOID RECEPTOR","Escherichia coli;Homo sapiens",4,"SER A 123;THR A 199;ILE A 208;THR A 117","None","1.01A","4acbC-6b73A:undetectable","4acbC-6b73A:undetectable"],["4QA0_B_SHHB404_2","HISTONE DEACETYLASE 8","6b73","SOLUBLE CYTOCHROME B562, KAPPA-TYPE OPIOID RECEPTOR","Escherichia coli;Homo sapiens",5,"PHE A 283;HIS A 291;PHE A 235;MET A 142;GLY A 319","None;CVV A2001 ( 4.5A);None;CVV A2001 (-3.6A);CVV A2001 (-3.7A)","1.36A","4qa0B-6b73A:undetectable","4qa0B-6b73A:13.71"]]