SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		6 / 9 ASP B 189
ALA B 190
SER B 195
TRP B 215
GLY B 216
GLY B 226
 BEN  B 301 (-2.7A)
BEN  B 301 (-4.1A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.41A 1bcuH-6b74B:
34.9		 1bcuH-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 9 HIS B  57
ASP B 189
SER B 195
TRP B 215
GLY B 226
 SO4  B 304 (-3.8A)
BEN  B 301 (-2.7A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.1A)
 0.49A 1dwcH-6b74B:
34.5		 1dwcH-6b74B:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		6 / 12 HIS B  57
ASP B 189
SER B 195
TRP B 215
GLY B 216
GLY B 226
 SO4  B 304 (-3.8A)
BEN  B 301 (-2.7A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.58A 1etrH-6b74B:
34.4		 1etrH-6b74B:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 8 ASP B 189
GLN B 192
SER B 195
GLY B 216
GLY B 226
 BEN  B 301 (-2.7A)
SO4  B 304 (-4.4A)
SO4  B 304 ( 2.5A)
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.51A 1f5lA-6b74B:
36.7		 1f5lA-6b74B:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 GLY B 216
ASP B 102
HIS B  57
ALA B  55
 BEN  B 301 (-3.3A)
None
SO4  B 304 (-3.8A)
None
 0.96A 1gxsA-6b74B:
undetectable
1gxsB-6b74B:
undetectable		 1gxsA-6b74B:
undetectable
1gxsB-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 10 SER B 195
SER B 214
ILE B 212
GLY B 211
GLY B 226
 SO4  B 304 ( 2.5A)
None
None
None
BEN  B 301 (-3.1A)
 1.29A 1mehA-6b74B:
undetectable		 1mehA-6b74B:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 GLY B 142
GLN B 156
VAL B 138
ALA B 190
 None
SO4  B 306 (-4.5A)
None
BEN  B 301 (-4.1A)
 0.93A 1p6kA-6b74B:
undetectable		 1p6kA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 11 ALA B  22
GLY B  69
GLY B  25
TYR B 117
VAL B 118
 None
 1.17A 1pg2A-6b74B:
undetectable		 1pg2A-6b74B:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 8 ASP B 102
PHE B  94
SER B 195
ALA B 104
 None
None
SO4  B 304 ( 2.5A)
None
 1.07A 1rqpC-6b74B:
undetectable		 1rqpC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 8 ASP B 102
PHE B  94
SER B 195
ALA B 104
 None
None
SO4  B 304 ( 2.5A)
None
 1.06A 1rqpA-6b74B:
undetectable		 1rqpA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 ASP B 189
SER B 195
GLY B 216
GLY B 226
 BEN  B 301 (-2.7A)
SO4  B 304 ( 2.5A)
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.23A 1tnlA-6b74B:
13.8		 1tnlA-6b74B:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.33A 1v54A-6b74B:
undetectable
1v54C-6b74B:
undetectable		 1v54A-6b74B:
undetectable
1v54C-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.32A 1v54N-6b74B:
undetectable
1v54P-6b74B:
undetectable		 1v54N-6b74B:
undetectable
1v54P-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.37A 1v55A-6b74B:
undetectable
1v55C-6b74B:
undetectable		 1v55A-6b74B:
undetectable
1v55C-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.34A 2dyrA-6b74B:
undetectable
2dyrC-6b74B:
undetectable		 2dyrA-6b74B:
undetectable
2dyrC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.33A 2dyrN-6b74B:
undetectable
2dyrP-6b74B:
undetectable		 2dyrN-6b74B:
undetectable
2dyrP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.37A 2dysA-6b74B:
undetectable
2dysC-6b74B:
undetectable		 2dysA-6b74B:
undetectable
2dysC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.31A 2dysN-6b74B:
undetectable
2dysP-6b74B:
undetectable		 2dysN-6b74B:
undetectable
2dysP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.34A 2eijA-6b74B:
undetectable
2eijC-6b74B:
undetectable		 2eijA-6b74B:
undetectable
2eijC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.33A 2eijN-6b74B:
undetectable
2eijP-6b74B:
undetectable		 2eijN-6b74B:
undetectable
2eijP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.35A 2eikA-6b74B:
undetectable
2eikC-6b74B:
undetectable		 2eikA-6b74B:
undetectable
2eikC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.32A 2eikN-6b74B:
undetectable
2eikP-6b74B:
undetectable		 2eikN-6b74B:
undetectable
2eikP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.36A 2eilA-6b74B:
undetectable
2eilC-6b74B:
undetectable		 2eilA-6b74B:
undetectable
2eilC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.33A 2eilN-6b74B:
undetectable
2eilP-6b74B:
undetectable		 2eilN-6b74B:
undetectable
2eilP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.35A 2eimA-6b74B:
undetectable
2eimC-6b74B:
undetectable		 2eimA-6b74B:
undetectable
2eimC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.31A 2eimN-6b74B:
undetectable
2eimP-6b74B:
undetectable		 2eimN-6b74B:
undetectable
2eimP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.33A 2einA-6b74B:
undetectable
2einC-6b74B:
undetectable		 2einA-6b74B:
undetectable
2einC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.38A 2einN-6b74B:
undetectable
2einP-6b74B:
undetectable		 2einN-6b74B:
undetectable
2einP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 12 ARG B  73
ASP B 194
ALA B 190
GLY B  18
GLY B  19
 SO4  B 305 (-3.8A)
None
BEN  B 301 (-4.1A)
None
None
 1.11A 2o4kA-6b74B:
undetectable		 2o4kA-6b74B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 GLY B  44
GLY B 197
VAL B  66
LEU B 106
 None
 0.83A 2oa1B-6b74B:
undetectable		 2oa1B-6b74B:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 ASP B 189
SER B 195
GLY B 216
GLY B 226
 BEN  B 301 (-2.7A)
SO4  B 304 ( 2.5A)
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.22A 2otvA-6b74B:
13.7		 2otvA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		6 / 12 GLY B 142
GLY B  44
GLY B 196
GLY B 193
THR B  54
LEU B  53
 None
None
None
SO4  B 304 (-3.7A)
None
None
 1.45A 2oxtD-6b74B:
undetectable		 2oxtD-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		8 / 12 TYR B  99
ASP B 189
ALA B 190
SER B 195
TRP B 215
GLY B 216
GLY B 226
TYR B 228
 None
BEN  B 301 (-2.7A)
BEN  B 301 (-4.1A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
None
 0.38A 2p16A-6b74B:
34.1		 2p16A-6b74B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 8 ASP B 102
PHE B  94
SER B 195
ALA B 104
 None
None
SO4  B 304 ( 2.5A)
None
 1.08A 2v7uA-6b74B:
2.5		 2v7uA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		9 / 12 TYR B  99
ASP B 189
ALA B 190
SER B 195
TRP B 215
GLY B 216
GLY B 219
GLY B 226
TYR B 228
 None
BEN  B 301 (-2.7A)
BEN  B 301 (-4.1A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
SO4  B 307 ( 3.4A)
BEN  B 301 (-3.1A)
None
 0.58A 2w26A-6b74B:
34.1		 2w26A-6b74B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.34A 2y69A-6b74B:
undetectable
2y69C-6b74B:
undetectable		 2y69A-6b74B:
undetectable
2y69C-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.38A 2zxwA-6b74B:
undetectable
2zxwC-6b74B:
undetectable		 2zxwA-6b74B:
undetectable
2zxwC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.35A 2zxwN-6b74B:
undetectable
2zxwP-6b74B:
undetectable		 2zxwN-6b74B:
undetectable
2zxwP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.39A 3abkA-6b74B:
undetectable
3abkC-6b74B:
undetectable		 3abkA-6b74B:
undetectable
3abkC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.33A 3abkN-6b74B:
undetectable
3abkP-6b74B:
undetectable		 3abkN-6b74B:
undetectable
3abkP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.35A 3abmN-6b74B:
undetectable
3abmP-6b74B:
undetectable		 3abmN-6b74B:
undetectable
3abmP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.36A 3ag1N-6b74B:
undetectable
3ag1P-6b74B:
undetectable		 3ag1N-6b74B:
undetectable
3ag1P-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.38A 3ag2A-6b74B:
undetectable
3ag2C-6b74B:
undetectable		 3ag2A-6b74B:
undetectable
3ag2C-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.36A 3ag2N-6b74B:
undetectable
3ag2P-6b74B:
undetectable		 3ag2N-6b74B:
undetectable
3ag2P-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.40A 3ag3A-6b74B:
undetectable
3ag3C-6b74B:
undetectable		 3ag3A-6b74B:
undetectable
3ag3C-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.36A 3ag3N-6b74B:
undetectable
3ag3P-6b74B:
undetectable		 3ag3N-6b74B:
undetectable
3ag3P-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.39A 3ag4A-6b74B:
undetectable
3ag4C-6b74B:
undetectable		 3ag4A-6b74B:
undetectable
3ag4C-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.35A 3ag4N-6b74B:
undetectable
3ag4P-6b74B:
undetectable		 3ag4N-6b74B:
undetectable
3ag4P-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.38A 3asnA-6b74B:
undetectable
3asnC-6b74B:
undetectable		 3asnA-6b74B:
undetectable
3asnC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		6 / 11 HIS B  57
ASP B 189
SER B 195
TRP B 215
GLY B 216
GLY B 226
 SO4  B 304 (-3.8A)
BEN  B 301 (-2.7A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.31A 3gy3A-6b74B:
13.7		 3gy3A-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 12 GLY B 197
PHE B  41
TYR B  34
GLY B 140
LEU B 155
 None
SO4  B 305 (-4.0A)
NAG  B 309 ( 3.6A)
None
None
 1.01A 3hs6B-6b74B:
undetectable		 3hs6B-6b74B:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 SER B 195
TRP B 215
GLY B 216
GLY B 226
 SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.24A 3rxfA-6b74B:
14.3		 3rxfA-6b74B:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 11 VAL B  85
VAL B  52
ALA B  55
LEU B 108
LEU B  64
 None
 1.00A 3sm2B-6b74B:
undetectable		 3sm2B-6b74B:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 5 LEU B  20
GLY B  19
THR B 188
VAL B 160
 None
 0.87A 3wriA-6b74B:
undetectable		 3wriA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 5 LEU B  20
GLY B  19
THR B 188
VAL B 160
 None
 0.86A 3wriB-6b74B:
undetectable		 3wriB-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 5 LEU B  20
GLY B  19
THR B 188
VAL B 160
 None
 0.91A 3wrkD-6b74B:
undetectable		 3wrkD-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 12 LEU B  64
GLY B 197
GLY B 196
LEU B 106
GLY B 193
 None
None
None
None
SO4  B 304 (-3.7A)
 0.76A 4dc3B-6b74B:
undetectable		 4dc3B-6b74B:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 5 HIS B  57
TYR B 151
GLN B 192
GLY B 193
SER B 195
 SO4  B 304 (-3.8A)
None
SO4  B 304 (-4.4A)
SO4  B 304 (-3.7A)
SO4  B 304 ( 2.5A)
 0.43A 4fu8A-6b74B:
37.0		 4fu8A-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 12 HIS B  57
ASP B 189
ALA B 190
TRP B 215
GLY B 226
 SO4  B 304 (-3.8A)
BEN  B 301 (-2.7A)
BEN  B 301 (-4.1A)
None
BEN  B 301 (-3.1A)
 0.44A 4hfpD-6b74B:
34.3		 4hfpD-6b74B:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		3 / 3 ASP B 102
TRP B  37
SER B 195
 None
None
SO4  B 304 ( 2.5A)
 0.83A 4lrhB-6b74B:
undetectable		 4lrhB-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		3 / 3 ASP B 102
TRP B  37
SER B 195
 None
None
SO4  B 304 ( 2.5A)
 0.85A 4lrhF-6b74B:
undetectable		 4lrhF-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 12 HIS B  57
ALA B 190
TRP B 215
GLY B 216
GLY B 226
 SO4  B 304 (-3.8A)
BEN  B 301 (-4.1A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.71A 4rn6B-6b74B:
29.1		 4rn6B-6b74B:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		5 / 12 LEU B  68
ALA B  31
THR B 242
ALA B  48
ALA B 112
 None
 1.21A 4x1iB-6b74B:
undetectable		 4x1iB-6b74B:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.37A 5b1aN-6b74B:
undetectable
5b1aP-6b74B:
undetectable		 5b1aN-6b74B:
undetectable
5b1aP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.37A 5b1bN-6b74B:
undetectable
5b1bP-6b74B:
undetectable		 5b1bN-6b74B:
undetectable
5b1bP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.37A 5b3sN-6b74B:
undetectable
5b3sP-6b74B:
undetectable		 5b3sN-6b74B:
undetectable
5b3sP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		6 / 12 GLY B 142
GLY B  44
GLY B 196
GLY B 193
THR B  54
VAL B  52
 None
None
None
SO4  B 304 (-3.7A)
None
None
 1.32A 5eiwC-6b74B:
undetectable		 5eiwC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.39A 5iy5A-6b74B:
undetectable
5iy5C-6b74B:
undetectable		 5iy5A-6b74B:
undetectable
5iy5C-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.36A 5x19N-6b74B:
undetectable
5x19P-6b74B:
undetectable		 5x19N-6b74B:
undetectable
5x19P-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.41A 5x1bN-6b74B:
undetectable
5x1bP-6b74B:
undetectable		 5x1bN-6b74B:
undetectable
5x1bP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.39A 5x1fN-6b74B:
undetectable
5x1fP-6b74B:
undetectable		 5x1fN-6b74B:
undetectable
5x1fP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		6 / 12 LEU B 155
ILE B  30
GLY B 197
LEU B 106
VAL B  66
LEU B 123
 None
 1.35A 5ycnA-6b74B:
undetectable		 5ycnA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.39A 5zcqN-6b74B:
undetectable
5zcqP-6b74B:
undetectable		 5zcqN-6b74B:
undetectable
5zcqP-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.34A 6nknA-6b74B:
undetectable
6nknC-6b74B:
undetectable		 6nknA-6b74B:
undetectable
6nknC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 6 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.38A 6nmpA-6b74B:
undetectable
6nmpC-6b74B:
undetectable		 6nmpA-6b74B:
undetectable
6nmpC-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6b74 COAGULATION FACTOR
XII
(Homo
sapiens) 		4 / 7 HIS B  57
ASP B 230
THR B 229
TYR B 228
 SO4  B 304 (-3.8A)
None
None
None
 1.39A 6nmpN-6b74B:
undetectable
6nmpP-6b74B:
undetectable		 6nmpN-6b74B:
undetectable
6nmpP-6b74B:
undetectable