SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 11 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.42A 1fkpA-6b7kA:
undetectable		 1fkpA-6b7kA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 8 SER A  87
ALA A 128
PHE A 126
ILE A 129
 None
 1.14A 1gm7A-6b7kA:
undetectable
1gm7B-6b7kA:
undetectable		 1gm7A-6b7kA:
undetectable
1gm7B-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 9 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.35A 1ikvA-6b7kA:
undetectable		 1ikvA-6b7kA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 10 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.29A 1ikwA-6b7kA:
undetectable		 1ikwA-6b7kA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 4 GLY A  29
LEU A  30
GLY A  27
ARG A  35
 None
 1.26A 1j7kA-6b7kA:
undetectable		 1j7kA-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 11 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.32A 1lwcA-6b7kA:
undetectable		 1lwcA-6b7kA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 9 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.30A 1vrtA-6b7kA:
undetectable		 1vrtA-6b7kA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 12 ILE A  75
ALA A 101
PHE A  26
SER A 108
ILE A 106
 None
 1.16A 2bl9A-6b7kA:
undetectable		 2bl9A-6b7kA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 10 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.36A 2hnyA-6b7kA:
undetectable		 2hnyA-6b7kA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 11 GLY A 151
SER A 170
ILE A 171
LEU A 195
VAL A 197
 None
 0.93A 2kawA-6b7kA:
undetectable		 2kawA-6b7kA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 11 ILE A  17
ILE A 106
ILE A  51
PHE A  26
THR A  22
 None
 1.05A 2w9sA-6b7kA:
undetectable		 2w9sA-6b7kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 11 ILE A  17
ILE A 106
ILE A  51
PHE A  26
THR A  22
 None
 1.05A 2w9sB-6b7kA:
undetectable		 2w9sB-6b7kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 10 ILE A  17
ILE A 106
ILE A  51
PHE A  26
THR A  22
 None
 1.04A 2w9sC-6b7kA:
undetectable		 2w9sC-6b7kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 7 TYR A  82
LEU A  84
SER A 107
THR A  22
 None
 0.80A 3lm8A-6b7kA:
undetectable
3lm8C-6b7kA:
undetectable		 3lm8A-6b7kA:
14.86
3lm8C-6b7kA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 10 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.38A 3lp1A-6b7kA:
undetectable		 3lp1A-6b7kA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 12 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.33A 3medA-6b7kA:
undetectable
3medB-6b7kA:
undetectable		 3medA-6b7kA:
undetectable
3medB-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 8 SER A 120
ASN A 127
GLN A 125
PHE A 126
 None
 1.30A 3n62A-6b7kA:
undetectable		 3n62A-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 8 SER A 120
ASN A 127
GLN A 125
PHE A 126
 None
 1.28A 3n66B-6b7kA:
undetectable		 3n66B-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 10 ILE A  75
ALA A 101
PHE A  26
SER A 108
ILE A 106
 None
 1.16A 3qgtA-6b7kA:
undetectable		 3qgtA-6b7kA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		5 / 11 THR A 218
THR A 221
GLY A 222
PRO A 223
ASP A 136
 None
 1.47A 3t8nD-6b7kA:
undetectable
3t8nF-6b7kA:
undetectable		 3t8nD-6b7kA:
undetectable
3t8nF-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 7 ASN A 127
ALA A 128
VAL A  63
ARG A 119
 None
 1.10A 4ijiH-6b7kA:
undetectable		 4ijiH-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 7 SER A 120
ASN A 127
GLN A 125
PHE A 126
 None
 1.25A 4kcnB-6b7kA:
undetectable		 4kcnB-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 8 SER A 228
TYR A 224
ALA A 172
GLY A 235
 None
 0.83A 5albL-6b7kA:
undetectable		 5albL-6b7kA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		3 / 3 ILE A 186
MET A 162
ASP A 136
 None
 0.76A 5h2uA-6b7kA:
undetectable		 5h2uA-6b7kA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 7 PRO A  14
ILE A 278
THR A  25
ILE A  37
 None
 0.83A 5murB-6b7kA:
undetectable		 5murB-6b7kA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		3 / 3 TYR A  82
SER A  76
TRP A 111
 None
 1.01A 5n8jB-6b7kA:
undetectable		 5n8jB-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		3 / 3 TYR A  82
SER A  76
TRP A 111
 None
 1.03A 5n8jA-6b7kA:
undetectable		 5n8jA-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		3 / 3 TYR A  82
SER A  76
TRP A 111
 None
 1.06A 5n8jD-6b7kA:
undetectable		 5n8jD-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 8 SER A 120
ASN A 127
GLN A 125
PHE A 126
 None
 1.29A 5vunA-6b7kA:
undetectable		 5vunA-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 8 SER A 120
ASN A 127
GLN A 125
PHE A 126
 None
 1.23A 5vunB-6b7kA:
undetectable		 5vunB-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 8 SER A 120
ASN A 127
GLN A 125
PHE A 126
 None
 1.24A 5vuoB-6b7kA:
undetectable		 5vuoB-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE
(Bacillus
licheniformis) 		4 / 8 SER A 120
ASN A 127
GLN A 125
PHE A 126
 None
 1.29A 6auuB-6b7kA:
undetectable		 6auuB-6b7kA:
undetectable