SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b82'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 12 ARG A 273
SER A 199
PHE A 197
LEU A 256
LEU A 280
 None
None
ACT  A 603 (-4.0A)
None
None
 1.48A 1p33C-6b82A:
undetectable		 1p33C-6b82A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 10 GLU A  97
GLY A  74
ASP A  75
THR A 396
TYR A 395
 None
 1.48A 2b82A-6b82A:
undetectable		 2b82A-6b82A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		3 / 3 GLN A 388
LYS A 399
VAL A 397
 None
 0.93A 2jfaB-6b82A:
undetectable		 2jfaB-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		3 / 3 ARG A 203
THR A 171
VAL A 169
 None
 0.95A 2q64A-6b82A:
undetectable		 2q64A-6b82A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 12 ALA A 126
ALA A 313
THR A 317
VAL A 494
GLY A 492
 HEM  A 601 (-3.8A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
None
None
 1.26A 2ve3B-6b82A:
37.4		 2ve3B-6b82A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		4 / 8 ASN A  90
ILE A  88
PHE A  65
TYR A  77
 None
 1.37A 3ccfB-6b82A:
undetectable		 3ccfB-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 12 LEU A  44
PRO A 110
SER A  78
LEU A  69
PHE A  66
 None
 1.18A 3e23A-6b82A:
undetectable		 3e23A-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		3 / 3 ALA A 313
THR A 317
CYH A 453
 HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
HEM  A 601 (-2.3A)
 0.77A 3e4eA-6b82A:
44.2		 3e4eA-6b82A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		3 / 3 ALA A 313
THR A 317
CYH A 453
 HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
HEM  A 601 (-2.3A)
 0.68A 3e4eB-6b82A:
44.1		 3e4eB-6b82A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		3 / 3 ASN A  90
HIS A  94
VAL A 392
 None
 0.69A 3elzB-6b82A:
undetectable		 3elzB-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		3 / 3 THR A 319
LYS A 259
GLU A 316
 None
 0.95A 3ijdB-6b82A:
undetectable		 3ijdB-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		3 / 3 ARG A 252
ASP A 121
GLN A 235
 None
 0.71A 3lcvB-6b82A:
undetectable		 3lcvB-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 12 LEU A 436
ASN A 430
TYR A 363
GLY A 433
GLU A 365
 None
 1.32A 3medA-6b82A:
undetectable
3medB-6b82A:
undetectable		 3medA-6b82A:
undetectable
3medB-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		9 / 12 ALA A 126
PHE A 127
TYR A 214
ILE A 218
ALA A 313
THR A 317
VAL A 377
CYH A 453
VAL A 493
 HEM  A 601 (-3.8A)
None
None
AER  A 602 (-3.9A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
HEM  A 601 ( 4.4A)
HEM  A 601 (-2.3A)
AER  A 602 ( 4.7A)
 0.62A 3rukA-6b82A:
48.9		 3rukA-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		8 / 12 ALA A 126
PHE A 127
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
None
 0.61A 3rukB-6b82A:
49.0		 3rukB-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		6 / 9 ALA A 126
PHE A 127
TYR A 214
ILE A 218
GLU A 316
THR A 317
 HEM  A 601 (-3.8A)
None
None
AER  A 602 (-3.9A)
None
HEM  A 601 ( 3.7A)
 0.87A 3rukC-6b82A:
48.6		 3rukC-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 9 TYR A 214
ILE A 218
ARG A 252
GLU A 316
THR A 317
 None
AER  A 602 (-3.9A)
None
None
HEM  A 601 ( 3.7A)
 0.98A 3rukC-6b82A:
48.6		 3rukC-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		8 / 11 ALA A 126
PHE A 127
TYR A 214
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 377
 HEM  A 601 (-3.8A)
None
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
HEM  A 601 ( 4.4A)
 0.52A 3rukD-6b82A:
48.7		 3rukD-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		8 / 11 ALA A 126
TYR A 214
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 377
 HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
None
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
HEM  A 601 ( 4.4A)
 0.64A 3rukD-6b82A:
48.7		 3rukD-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 12 SER A 285
PHE A 136
GLN A 272
MET A 140
GLY A 143
 None
 1.32A 4j7xA-6b82A:
undetectable		 4j7xA-6b82A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		4 / 8 PHE A 208
THR A 189
VAL A 315
PHE A 311
 None
None
None
ACT  A 603 ( 4.4A)
 0.89A 4ltwA-6b82A:
2.0		 4ltwA-6b82A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
None
 0.53A 4nkvA-6b82A:
49.2		 4nkvA-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		7 / 12 LEU A 118
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 494
 None
AER  A 602 (-3.9A)
None
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
None
 0.54A 4nkvA-6b82A:
49.2		 4nkvA-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
None
 0.51A 4nkvB-6b82A:
49.2		 4nkvB-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
None
 0.51A 4nkvC-6b82A:
49.2		 4nkvC-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		7 / 12 LEU A 118
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 494
 None
AER  A 602 (-3.9A)
None
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
None
 0.62A 4nkvC-6b82A:
49.2		 4nkvC-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
None
 0.51A 4nkvD-6b82A:
49.2		 4nkvD-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		7 / 12 LEU A 118
ILE A 218
ARG A 252
GLY A 312
ALA A 313
THR A 317
VAL A 494
 None
AER  A 602 (-3.9A)
None
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
None
 0.58A 4nkvD-6b82A:
49.2		 4nkvD-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
None
 0.52A 4nkxA-6b82A:
48.6		 4nkxA-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
THR A 317
ILE A 382
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 ( 3.7A)
None
AER  A 602 ( 4.7A)
None
 0.62A 4nkxA-6b82A:
48.6		 4nkxA-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		8 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
THR A 317
ILE A 382
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
HEM  A 601 ( 3.7A)
None
AER  A 602 ( 4.7A)
None
 0.60A 4nkxA-6b82A:
48.6		 4nkxA-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
ILE A 382
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
None
AER  A 602 ( 4.7A)
None
 0.63A 4nkxC-6b82A:
48.9		 4nkxC-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
ALA A 313
THR A 317
ILE A 382
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
None
AER  A 602 ( 4.7A)
None
 0.67A 4nkxC-6b82A:
48.9		 4nkxC-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
None
 0.64A 4nkxD-6b82A:
48.7		 4nkxD-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		9 / 12 LEU A 118
ALA A 126
PHE A 127
ILE A 218
GLY A 312
THR A 317
ILE A 382
VAL A 493
VAL A 494
 None
HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 ( 3.7A)
None
AER  A 602 ( 4.7A)
None
 0.65A 4nkxD-6b82A:
48.7		 4nkxD-6b82A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		4 / 6 MET A 372
ILE A 155
ILE A 159
VAL A 191
 HEM  A 601 ( 4.4A)
None
None
None
 0.93A 4olmA-6b82A:
undetectable		 4olmA-6b82A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		7 / 9 ALA A 126
TYR A 214
ILE A 218
GLY A 312
ALA A 313
THR A 317
VAL A 493
 HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
 0.68A 4r1zA-6b82A:
52.7		 4r1zA-6b82A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		6 / 9 ALA A 126
TYR A 214
SER A 215
GLY A 312
ALA A 313
VAL A 494
 HEM  A 601 (-3.8A)
None
AER  A 602 (-3.4A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
None
 0.99A 4r1zA-6b82A:
52.7		 4r1zA-6b82A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		7 / 9 ALA A 126
TYR A 214
SER A 215
ILE A 218
GLY A 312
ALA A 313
THR A 317
 HEM  A 601 (-3.8A)
None
AER  A 602 (-3.4A)
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
 0.44A 4r1zA-6b82A:
52.7		 4r1zA-6b82A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		7 / 7 ALA A 126
SER A 215
GLY A 312
ALA A 313
GLU A 316
THR A 317
SER A 378
 HEM  A 601 (-3.8A)
AER  A 602 (-3.4A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
None
HEM  A 601 ( 3.7A)
AER  A 602 (-3.2A)
 0.58A 4r1zB-6b82A:
52.1		 4r1zB-6b82A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		6 / 8 ALA A 126
GLU A 309
GLY A 312
THR A 317
VAL A 377
SER A 378
 HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 ( 3.7A)
HEM  A 601 ( 4.4A)
AER  A 602 (-3.2A)
 0.51A 4r20A-6b82A:
47.5		 4r20A-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		6 / 8 ALA A 126
ILE A 218
GLU A 309
GLY A 312
THR A 317
SER A 378
 HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 ( 3.7A)
AER  A 602 (-3.2A)
 0.69A 4r20A-6b82A:
47.5		 4r20A-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		6 / 9 ALA A 126
PHE A 127
ILE A 218
GLY A 312
THR A 317
SER A 378
 HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 ( 3.7A)
AER  A 602 (-3.2A)
 0.75A 4r20B-6b82A:
47.0		 4r20B-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		6 / 9 ALA A 126
PHE A 127
ILE A 218
VAL A 219
GLY A 312
THR A 317
 HEM  A 601 (-3.8A)
None
AER  A 602 (-3.9A)
AER  A 602 (-4.8A)
AER  A 602 ( 3.7A)
HEM  A 601 ( 3.7A)
 0.85A 4r20B-6b82A:
47.0		 4r20B-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 9 ALA A 126
PHE A 127
VAL A 219
GLY A 312
VAL A 494
 HEM  A 601 (-3.8A)
None
AER  A 602 (-4.8A)
AER  A 602 ( 3.7A)
None
 1.24A 4r20B-6b82A:
47.0		 4r20B-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		4 / 6 ALA A 126
ILE A 218
SER A 378
ILE A 382
 HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 (-3.2A)
None
 0.48A 4r21A-6b82A:
46.5		 4r21A-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		6 / 9 ALA A 126
ILE A 218
GLY A 312
ALA A 313
THR A 317
SER A 378
 HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 (-3.2A)
 1.15A 4r21B-6b82A:
46.9		 4r21B-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		6 / 9 ALA A 126
ILE A 218
GLY A 312
THR A 317
SER A 378
ILE A 382
 HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 ( 3.7A)
HEM  A 601 ( 3.7A)
AER  A 602 (-3.2A)
None
 1.08A 4r21B-6b82A:
46.9		 4r21B-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		6 / 9 ALA A 126
ILE A 218
VAL A 219
GLY A 312
ALA A 313
THR A 317
 HEM  A 601 (-3.8A)
AER  A 602 (-3.9A)
AER  A 602 (-4.8A)
AER  A 602 ( 3.7A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
 1.19A 4r21B-6b82A:
46.9		 4r21B-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 9 ILE A 218
VAL A 219
ALA A 313
THR A 317
VAL A 493
 AER  A 602 (-3.9A)
AER  A 602 (-4.8A)
HEM  A 601 (-3.6A)
HEM  A 601 ( 3.7A)
AER  A 602 ( 4.7A)
 0.81A 4r21B-6b82A:
46.9		 4r21B-6b82A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		4 / 4 LEU A 279
ILE A 125
HIS A 137
VAL A 141
 None
HEM  A 601 (-4.4A)
None
None
 1.09A 4xyzA-6b82A:
undetectable		 4xyzA-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		4 / 6 TYR A 214
TYR A 201
GLY A 308
ASP A 124
 None
 1.35A 5emlA-6b82A:
undetectable		 5emlA-6b82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 9 GLY A 312
TYR A 214
VAL A 315
GLU A 316
GLY A 308
 AER  A 602 ( 3.7A)
None
None
None
None
 1.13A 5zniA-6b82A:
undetectable		 5zniA-6b82A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 12 GLU A 316
PRO A 497
VAL A 502
PHE A 208
PHE A 500
 None
 1.34A 6becA-6b82A:
undetectable
6becB-6b82A:
undetectable
6becC-6b82A:
undetectable		 6becA-6b82A:
8.23
6becB-6b82A:
8.23
6becC-6b82A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1
(Danio
rerio) 		5 / 10 GLU A 316
PRO A 497
VAL A 502
PHE A 208
PHE A 500
 None
 1.36A 6behA-6b82A:
undetectable
6behB-6b82A:
undetectable
6behC-6b82A:
undetectable		 6behA-6b82A:
8.40
6behB-6b82A:
8.40
6behC-6b82A:
8.40