SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 131
ASP A 150
ASN A 220
 None
 0.83A 2bm9D-6b8aA:
undetectable		 2bm9D-6b8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 285
PHE A 281
LEU A 163
ALA A 146
ILE A 145
 None
 1.25A 2bxpA-6b8aA:
undetectable		 2bxpA-6b8aA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 237
VAL A 170
TRP A 234
 None
CZG  A 301 (-4.9A)
None
 0.81A 3l8lA-6b8aA:
undetectable
3l8lB-6b8aA:
undetectable		 3l8lA-6b8aA:
undetectable
3l8lB-6b8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 281
PHE A 284
ALA A 146
THR A 148
ILE A 103
 None
 1.38A 3t3qC-6b8aA:
undetectable		 3t3qC-6b8aA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 281
PHE A 284
ALA A 146
THR A 148
ILE A 103
 None
 1.39A 3t3qD-6b8aA:
undetectable		 3t3qD-6b8aA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 147
VAL A 122
PHE A 284
ARG A 289
 None
 1.19A 4xe5A-6b8aA:
undetectable		 4xe5A-6b8aA:
6.73