SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		4 / 7 ILE A  40
GLY A  41
PHE A 202
ASN A 194
 None
 0.97A 1oniG-6b8dA:
1.0
1oniI-6b8dA:
undetectable		 1oniG-6b8dA:
17.39
1oniI-6b8dA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		4 / 6 ILE A 292
TYR A 133
ILE A 295
HIS A 308
 None
 1.21A 3eteA-6b8dA:
undetectable
3eteE-6b8dA:
undetectable		 3eteA-6b8dA:
21.80
3eteE-6b8dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		4 / 5 ILE A 292
TYR A 133
ILE A 295
HIS A 308
 None
 1.20A 3eteB-6b8dA:
undetectable
3eteC-6b8dA:
undetectable		 3eteB-6b8dA:
21.80
3eteC-6b8dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		5 / 12 ARG A 137
ALA A 130
ILE A 138
MET A 278
LYS A  23
 None
 1.49A 3qt0A-6b8dA:
undetectable		 3qt0A-6b8dA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		3 / 3 PHE A  79
LYS A 249
SER A 250
 None
 1.34A 3tyeB-6b8dA:
undetectable		 3tyeB-6b8dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		5 / 10 ALA A 281
ILE A 248
LEU A 222
ILE A 186
ASP A 184
 None
 1.29A 4dtaA-6b8dA:
undetectable		 4dtaA-6b8dA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		4 / 8 ILE A  15
ILE A 138
PHE A 140
GLY A 274
 None
 0.97A 4hdlA-6b8dA:
undetectable		 4hdlA-6b8dA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		4 / 6 ARG A  11
GLU A   8
ASP A 291
ARG A 253
 None
 1.26A 4kcnA-6b8dA:
undetectable		 4kcnA-6b8dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		4 / 6 ARG A  11
GLU A   8
ASP A 291
ARG A 253
 None
 1.27A 4kcnB-6b8dA:
undetectable		 4kcnB-6b8dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		5 / 12 ILE A  30
THR A 265
ILE A 138
LEU A 286
PRO A 287
 None
 0.98A 4p3qA-6b8dA:
undetectable		 4p3qA-6b8dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		4 / 5 THR A   5
THR A   4
HIS A 365
ASN A  85
 None
 1.18A 4pgfB-6b8dA:
2.3		 4pgfB-6b8dA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		4 / 7 VAL A 182
MET A  75
ARG A  11
ILE A  30
 None
 0.85A 4uxqA-6b8dA:
undetectable		 4uxqA-6b8dA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 6b8d ELONGATION FACTOR G
(Haemophilus
influenzae) 		5 / 9 SER A 102
ALA A 109
VAL A 126
ALA A 130
VAL A  99
 None
 1.18A 6bklA-6b8dA:
undetectable
6bklB-6b8dA:
undetectable
6bklC-6b8dA:
undetectable
6bklD-6b8dA:
undetectable		 6bklA-6b8dA:
5.15
6bklB-6b8dA:
5.15
6bklC-6b8dA:
5.15
6bklD-6b8dA:
5.15