SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 6 SER A 131
GLY A 128
LEU A  92
GLU A  88
 None
 0.99A 1fduD-6b8sA:
undetectable		 1fduD-6b8sA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 6 ASN A 116
ASN A 178
ASN A 243
THR A 244
 FMN  A 401 (-3.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-3.6A)
FMN  A 401 ( 4.8A)
 0.53A 1h7xA-6b8sA:
30.4		 1h7xA-6b8sA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 6 ASN A 116
ASN A 178
ASN A 243
THR A 244
 FMN  A 401 (-3.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-3.6A)
FMN  A 401 ( 4.8A)
 0.53A 1h7xB-6b8sA:
30.4		 1h7xB-6b8sA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 6 ASN A 116
ASN A 178
ASN A 243
THR A 244
 FMN  A 401 (-3.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-3.6A)
FMN  A 401 ( 4.8A)
 0.53A 1h7xC-6b8sA:
30.4		 1h7xC-6b8sA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 6 ASN A 116
ASN A 178
ASN A 243
THR A 244
 FMN  A 401 (-3.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-3.6A)
FMN  A 401 ( 4.8A)
 0.53A 1h7xD-6b8sA:
30.4		 1h7xD-6b8sA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		5 / 11 ASN A  72
LEU A  26
HIS A  19
GLY A  90
PHE A 315
 None
None
PGE  A 402 (-3.9A)
None
PGE  A 402 (-4.0A)
 1.42A 1l5rA-6b8sA:
undetectable		 1l5rA-6b8sA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 5 LEU A  63
PRO A  62
LEU A 309
ILE A 292
 None
 0.77A 2qd4A-6b8sA:
undetectable		 2qd4A-6b8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 5 LEU A 322
GLY A 319
PHE A 315
PHE A  84
 None
PGE  A 402 ( 4.2A)
PGE  A 402 (-4.0A)
None
 1.21A 3smtA-6b8sA:
undetectable		 3smtA-6b8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		5 / 12 LEU A  57
LEU A  79
PHE A  59
ASN A  61
ALA A  66
 None
None
None
None
FMN  A 401 (-3.2A)
 0.92A 3uwlD-6b8sA:
undetectable		 3uwlD-6b8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		5 / 12 LEU A 169
TYR A 175
ALA A 125
PHE A 177
LEU A 146
 None
 1.45A 3vw1B-6b8sA:
undetectable		 3vw1B-6b8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 4 LEU A  63
PRO A  62
LEU A 309
ILE A 292
 None
 0.81A 4f4dB-6b8sA:
undetectable		 4f4dB-6b8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 5 LEU A  63
PRO A  62
LEU A 309
ILE A 292
 None
 0.89A 4klrA-6b8sA:
undetectable		 4klrA-6b8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		4 / 6 LEU A  76
TYR A 138
ILE A 171
GLY A 143
 None
 1.03A 4l39A-6b8sA:
1.2		 4l39A-6b8sA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		5 / 11 THR A  91
ALA A  96
GLY A 124
ASP A  70
LEU A  76
 FMN  A 401 (-3.8A)
None
None
None
None
 1.06A 5lf7H-6b8sA:
undetectable
5lf7I-6b8sA:
undetectable		 5lf7H-6b8sA:
undetectable
5lf7I-6b8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Helicobacter
pylori) 		5 / 11 THR A  91
ALA A  96
GLY A 124
ASP A  70
LEU A  76
 FMN  A 401 (-3.8A)
None
None
None
None
 1.10A 5lf7V-6b8sA:
undetectable
5lf7W-6b8sA:
undetectable		 5lf7V-6b8sA:
undetectable
5lf7W-6b8sA:
undetectable