SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 6b8v ADENYLYLSULFATE
KINASE
(Cryptococcus
neoformans) 		4 / 8 GLU A  81
ARG A  84
ARG A  85
LEU A  72
 None
 0.77A 1cmaA-6b8vA:
undetectable
1cmaB-6b8vA:
undetectable		 1cmaA-6b8vA:
21.89
1cmaB-6b8vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6b8v ADENYLYLSULFATE
KINASE
(Cryptococcus
neoformans) 		5 / 12 ILE A 175
SER A 100
ILE A  99
LEU A 195
ILE A 129
 None
 1.01A 1draA-6b8vA:
undetectable		 1draA-6b8vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6b8v ADENYLYLSULFATE
KINASE
(Cryptococcus
neoformans) 		5 / 12 ILE A 175
SER A 100
ILE A  99
LEU A 195
ILE A 129
 None
 1.00A 1drbA-6b8vA:
undetectable		 1drbA-6b8vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6b8v ADENYLYLSULFATE
KINASE
(Cryptococcus
neoformans) 		5 / 12 ILE A 175
SER A 100
ILE A  99
LEU A 195
ILE A 129
 None
 1.01A 2drcA-6b8vA:
undetectable		 2drcA-6b8vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6b8v ADENYLYLSULFATE
KINASE
(Cryptococcus
neoformans) 		5 / 12 ILE A 175
SER A 100
ILE A  99
LEU A 195
ILE A 129
 None
 1.01A 3drcA-6b8vA:
undetectable		 3drcA-6b8vA:
20.45