SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6b9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_A_FCNA1199_1
(EPOXIDASE)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		6 / 9 ARG A 102
TYR A 110
ASN A 145
HIS A 148
HIS A 190
ALA A 206
 None
None
FE  A 501 ( 4.9A)
FE  A 501 (-3.7A)
FE  A 501 (-3.6A)
None
 0.48A 2bnnA-6b9sA:
12.8
2bnnB-6b9sA:
9.8		 2bnnA-6b9sA:
14.65
2bnnB-6b9sA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		5 / 8 TYR A 110
ASN A 145
HIS A 148
HIS A 190
ALA A 206
 None
FE  A 501 ( 4.9A)
FE  A 501 (-3.7A)
FE  A 501 (-3.6A)
None
 0.44A 2bnnA-6b9sA:
12.8
2bnnB-6b9sA:
9.8		 2bnnA-6b9sA:
14.65
2bnnB-6b9sA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		5 / 12 HIS A 148
TYR A 108
TYR A 110
PHE A 192
ASN A 145
 FE  A 501 (-3.7A)
None
None
None
FE  A 501 ( 4.9A)
 1.50A 2oa1B-6b9sA:
undetectable		 2oa1B-6b9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		5 / 11 ILE A 312
ALA A 340
THR A 188
VAL A 311
THR A 339
 None
 1.23A 2w3aA-6b9sA:
undetectable		 2w3aA-6b9sA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		4 / 6 THR A 208
MET A 182
PHE A 162
ILE A 204
 None
 1.38A 2w98B-6b9sA:
undetectable		 2w98B-6b9sA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		5 / 12 LEU A 415
TYR A 368
LEU A 205
THR A 154
THR A 208
 None
 1.43A 3thrA-6b9sA:
undetectable
3thrB-6b9sA:
1.7
3thrC-6b9sA:
0.0
3thrD-6b9sA:
undetectable		 3thrA-6b9sA:
undetectable
3thrB-6b9sA:
undetectable
3thrC-6b9sA:
undetectable
3thrD-6b9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		4 / 8 PHE A 187
HIS A 190
GLY A 147
GLY A 210
 None
FE  A 501 (-3.6A)
None
None
 0.82A 3v3nB-6b9sA:
undetectable		 3v3nB-6b9sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		4 / 8 PHE A 187
HIS A 190
GLY A 147
GLY A 210
 None
FE  A 501 (-3.6A)
None
None
 0.81A 3v3nC-6b9sA:
undetectable		 3v3nC-6b9sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		4 / 5 VAL A 369
LEU A 392
ILE A 379
VAL A 351
 None
 0.96A 4a9kB-6b9sA:
undetectable		 4a9kB-6b9sA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		3 / 3 ARG A 195
ASP A 317
GLN A 318
 None
 0.85A 4azsA-6b9sA:
undetectable		 4azsA-6b9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		5 / 12 THR A 154
HIS A 190
ILE A 184
GLN A 152
ILE A 204
 None
FE  A 501 (-3.6A)
None
FE  A 501 (-2.9A)
None
 1.45A 4rp9A-6b9sA:
undetectable		 4rp9A-6b9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		4 / 6 ILE A 372
GLY A 410
ASN A 411
ILE A 414
 None
 0.93A 5j4nB-6b9sA:
undetectable		 5j4nB-6b9sA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		3 / 3 ARG A 409
ILE A 379
PHE A 408
 None
 0.68A 5kirA-6b9sA:
undetectable		 5kirA-6b9sA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		3 / 3 SER A 245
ALA A 242
THR A 307
 None
 0.75A 5n0xB-6b9sA:
undetectable		 5n0xB-6b9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 6b9s METHYLPHOSPHONATE
SYNTHASE
(Nitrosopumilus
maritimus) 		4 / 6 TYR A 110
LEU A 205
GLU A 128
LEU A 203
 None
 1.34A 5xooA-6b9sA:
undetectable		 5xooA-6b9sA:
21.59