SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ba5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
(Homo
sapiens) 		5 / 9 THR A  12
VAL A 110
LEU A  74
ILE A  76
ASP A  83
 None
 1.44A 1nb9A-6ba5A:
undetectable		 1nb9A-6ba5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
(Homo
sapiens) 		4 / 5 ILE A  30
ARG A  51
LEU A  34
ASN A  33
 None
 1.02A 1y0xX-6ba5A:
undetectable		 1y0xX-6ba5A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
(Homo
sapiens) 		4 / 5 ILE A  30
SER A  53
LEU A  34
ASN A  33
 None
 1.09A 1y0xX-6ba5A:
undetectable		 1y0xX-6ba5A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
(Homo
sapiens;
Homo
sapiens) 		5 / 9 LEU A  90
GLU B  45
ALA B  59
TYR B  58
LEU B  77
 None
 1.47A 2azqA-6ba5A:
undetectable		 2azqA-6ba5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 6ba5 INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
(Homo
sapiens) 		5 / 11 TYR B  96
PHE B 103
ASP B 102
ARG M 332
VAL A  96
 None
 1.40A 2vn1A-6ba5B:
undetectable		 2vn1A-6ba5B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6ba5 VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 THR M 328
ASP M 384
SER M 330
TYR B  99
 None
 1.41A 2xz5A-6ba5M:
undetectable
2xz5C-6ba5M:
undetectable		 2xz5A-6ba5M:
undetectable
2xz5C-6ba5M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 6ba5 VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS M 369
ILE B  33
PHE B  49
 None
 0.84A 3j7zS-6ba5M:
undetectable
3j7za-6ba5M:
undetectable		 3j7zS-6ba5M:
undetectable
3j7za-6ba5M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 6ba5 INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
(Homo
sapiens) 		4 / 8 SER B  26
ASP M 384
TYR B  31
LEU A  47
 None
 1.07A 3jq7B-6ba5B:
undetectable		 3jq7B-6ba5B:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6ba5 INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
(Homo
sapiens) 		3 / 3 THR M 317
ASN M 364
GLU M 370
 None
 0.76A 3v4tA-6ba5M:
undetectable
3v4tC-6ba5M:
undetectable		 3v4tA-6ba5M:
undetectable
3v4tC-6ba5M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6ba5 INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
(Homo
sapiens) 		3 / 3 THR M 317
ASN M 367
GLU M 370
 None
 0.76A 3v4tA-6ba5M:
undetectable
3v4tC-6ba5M:
undetectable		 3v4tA-6ba5M:
undetectable
3v4tC-6ba5M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 6ba5 INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
(Homo
sapiens) 		3 / 3 ASN A  95
TRP B  57
ASP M 378
 None
 1.27A 4a7tA-6ba5A:
undetectable
4a7tF-6ba5A:
undetectable		 4a7tA-6ba5A:
22.31
4a7tF-6ba5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
(Homo
sapiens) 		4 / 6 THR A 106
LEU A  34
GLN A  28
GLU A   2
 None
 1.26A 4nc3A-6ba5A:
undetectable		 4nc3A-6ba5A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE A  49
GLN A   7
TYR A  87
GLN B  38
LEU B  44
 None
 1.39A 4qztA-6ba5A:
undetectable		 4qztA-6ba5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
(Homo
sapiens) 		4 / 5 VAL A  20
ILE A  22
VAL A 108
THR A 106
 None
 0.75A 4xdtA-6ba5A:
undetectable		 4xdtA-6ba5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 6ba5 VARIABLE DOMAIN
HEAVY CHAIN,
ANTIBODY R11
INACTIVE
TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP M 378
SER B  97
TYR B  96
 None
 0.71A 5glmA-6ba5M:
undetectable		 5glmA-6ba5M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11
(Homo
sapiens) 		4 / 5 LEU A  55
LEU A  74
THR A  46
ARG A  81
 None
 0.96A 6ew0F-6ba5A:
undetectable		 6ew0F-6ba5A:
22.89