SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		5 / 10 LEU A 352
ALA A  97
ASP A  96
GLY A   7
VAL A  15
 None
 0.99A 1d4yA-6bacA:
undetectable		 1d4yA-6bacA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 362
ARG A 361
ILE A  95
 SO4  A 405 (-3.6A)
None
None
 0.64A 1uobA-6bacA:
undetectable		 1uobA-6bacA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		4 / 5 LEU A 353
ASP A 350
GLY A 166
ALA A 357
 None
 0.95A 2aohA-6bacA:
undetectable		 2aohA-6bacA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		4 / 5 GLY A 355
PRO A 113
VAL A 114
ILE A 252
 None
SO4  A 405 (-3.8A)
None
None
 0.90A 2aoiA-6bacA:
undetectable		 2aoiA-6bacA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		4 / 8 GLY A 145
PHE A 148
ASP A 151
THR A 260
 None
 0.94A 2aouA-6bacA:
undetectable		 2aouA-6bacA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		4 / 7 GLY A 145
PHE A 148
ASP A 151
THR A 260
 None
 0.97A 2aouB-6bacA:
undetectable		 2aouB-6bacA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		5 / 9 LEU A 152
LEU A 283
ILE A 343
LEU A 296
ILE A 295
 None
 1.05A 2f7aA-6bacA:
undetectable		 2f7aA-6bacA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		5 / 11 LEU A 352
ALA A  97
ASP A  96
GLY A   7
VAL A  15
 None
 1.04A 2o4pA-6bacA:
undetectable		 2o4pA-6bacA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		3 / 3 SER A 276
TYR A 161
HIS A 275
 None
 0.75A 2r2vD-6bacA:
undetectable		 2r2vD-6bacA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		4 / 6 LEU A 208
SER A 205
PHE A 207
ILE A 182
 None
 0.98A 3ko0B-6bacA:
undetectable		 3ko0B-6bacA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		5 / 11 THR A  36
GLN A  49
GLY A  41
THR A  53
ALA A  43
 SO4  A 401 (-4.3A)
None
None
None
None
 1.35A 3mg0H-6bacA:
undetectable
3mg0I-6bacA:
undetectable		 3mg0H-6bacA:
21.73
3mg0I-6bacA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		5 / 12 ARG A 268
SER A 165
ALA A 167
LEU A 175
ILE A 269
 SO4  A 403 (-4.1A)
None
SO4  A 403 ( 4.5A)
None
None
 1.24A 3qt0A-6bacA:
undetectable		 3qt0A-6bacA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		4 / 8 ILE A  95
TRP A 354
GLY A 133
ASN A 115
 None
 0.95A 4fgjA-6bacA:
3.7
4fgjB-6bacA:
3.6		 4fgjA-6bacA:
20.67
4fgjB-6bacA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		3 / 3 LYS A  52
ASN A  39
ASP A  46
 None
 0.80A 4o1eA-6bacA:
undetectable		 4o1eA-6bacA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 110
ASP A 120
ILE A 131
ASN A 129
GLY A 133
 None
 1.00A 4obwB-6bacA:
undetectable		 4obwB-6bacA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 147
LEU A 253
ALA A 345
GLY A 298
ALA A 299
 None
 0.87A 5jw1B-6bacA:
undetectable		 5jw1B-6bacA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		4 / 6 GLU A 358
ARG A  19
LEU A  16
ARG A 361
 None
 1.18A 5l6eA-6bacA:
undetectable
5l6eB-6bacA:
undetectable		 5l6eA-6bacA:
20.45
5l6eB-6bacA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		3 / 3 ALA A  98
GLN A  73
THR A  78
 EDO  A 406 ( 4.2A)
SO4  A 401 (-3.7A)
None
 0.63A 5n0oA-6bacA:
undetectable		 5n0oA-6bacA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		3 / 3 MET A 142
ASP A 112
ARG A  19
 None
 1.12A 5z6jA-6bacA:
undetectable		 5z6jA-6bacA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		3 / 3 MET A 142
ASP A 112
ARG A  19
 None
 1.09A 5z6kA-6bacA:
undetectable		 5z6kA-6bacA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		5 / 12 ILE A  29
PHE A   5
PHE A  47
ASP A  25
ILE A  95
 None
 1.43A 6dwnB-6bacA:
undetectable		 6dwnB-6bacA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 262
PHE A 148
ASN A 250
ILE A 279
LEU A 144
 None
 1.01A 6dwnC-6bacA:
undetectable		 6dwnC-6bacA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Neisseria
gonorrhoeae) 		4 / 7 VAL A  15
LEU A 326
GLY A 324
GLY A 166
 None
 0.69A 6eu9D-6bacA:
undetectable		 6eu9D-6bacA:
12.71