SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 12 LEU A 109
PHE A 104
ALA A 341
GLY A 347
LEU A 348
 None
OLC  A 402 (-4.6A)
OLC  A 402 (-3.7A)
None
None
 0.97A 1fe2A-6barA:
undetectable		 1fe2A-6barA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 12 LEU A 112
LEU A 115
LEU A 118
ALA A 119
LEU A 298
 None
 1.05A 1s9pC-6barA:
undetectable		 1s9pC-6barA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 11 LEU A 116
ALA A 119
LYS A 120
GLU A 123
LEU A  68
 None
 0.74A 2bxeB-6barA:
2.3		 2bxeB-6barA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		4 / 8 ALA A 119
LYS A 120
GLU A 123
LEU A  68
 None
 0.76A 2bxgA-6barA:
undetectable		 2bxgA-6barA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 12 LEU A 181
PHE A 309
GLY A 154
ALA A 156
LEU A 148
 None
 1.26A 3n8xA-6barA:
0.2		 3n8xA-6barA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		4 / 8 THR A 325
GLY A 155
GLN A 105
VAL A 158
 None
 0.99A 4e1vA-6barA:
undetectable		 4e1vA-6barA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		4 / 8 THR A 325
GLY A 155
GLN A 105
VAL A 158
 None
 0.99A 4e1vD-6barA:
undetectable		 4e1vD-6barA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		4 / 8 THR A 325
GLY A 155
GLN A 105
VAL A 158
 None
 0.97A 4e1vH-6barA:
undetectable		 4e1vH-6barA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 4qvmK-6barA:
undetectable
4qvmL-6barA:
undetectable		 4qvmK-6barA:
18.27
4qvmL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 4qvpK-6barA:
undetectable
4qvpL-6barA:
undetectable		 4qvpK-6barA:
17.26
4qvpL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 4qvpY-6barA:
undetectable
4qvpZ-6barA:
undetectable		 4qvpY-6barA:
17.26
4qvpZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 11 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.05A 4qvwK-6barA:
undetectable
4qvwL-6barA:
undetectable		 4qvwK-6barA:
17.59
4qvwL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 11 THR A 328
THR A 342
GLY A 335
GLY A 336
SER A 337
 None
None
None
OLC  A 402 ( 4.7A)
OLC  A 402 ( 4.6A)
 1.09A 4qvwK-6barA:
undetectable
4qvwL-6barA:
undetectable		 4qvwK-6barA:
17.59
4qvwL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 11 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.05A 4qvwY-6barA:
undetectable
4qvwZ-6barA:
undetectable		 4qvwY-6barA:
17.59
4qvwZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 11 THR A 328
THR A 342
GLY A 335
GLY A 336
SER A 337
 None
None
None
OLC  A 402 ( 4.7A)
OLC  A 402 ( 4.6A)
 1.09A 4qvwY-6barA:
undetectable
4qvwZ-6barA:
undetectable		 4qvwY-6barA:
17.59
4qvwZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.05A 4qw1Y-6barA:
undetectable
4qw1Z-6barA:
undetectable		 4qw1Y-6barA:
17.59
4qw1Z-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.05A 4qw3K-6barA:
undetectable
4qw3L-6barA:
undetectable		 4qw3K-6barA:
17.26
4qw3L-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 4qw3Y-6barA:
undetectable
4qw3Z-6barA:
undetectable		 4qw3Y-6barA:
17.26
4qw3Z-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.14A 4qwuK-6barA:
undetectable
4qwuL-6barA:
undetectable		 4qwuK-6barA:
17.77
4qwuL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.14A 4qwuY-6barA:
undetectable
4qwuZ-6barA:
undetectable		 4qwuY-6barA:
17.77
4qwuZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 5d0xK-6barA:
undetectable
5d0xL-6barA:
undetectable		 5d0xK-6barA:
17.26
5d0xL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 5d0xY-6barA:
undetectable
5d0xZ-6barA:
undetectable		 5d0xY-6barA:
17.26
5d0xZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 12 LEU A 181
LEU A 327
GLY A 155
ALA A 156
LEU A 148
 None
 1.10A 5ikqA-6barA:
0.0		 5ikqA-6barA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 12 LEU A 181
LEU A 327
GLY A 155
ALA A 156
LEU A 148
 None
 1.10A 5ikqB-6barA:
undetectable		 5ikqB-6barA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 12 LEU A 181
LEU A 327
GLY A 154
ALA A 156
LEU A 148
 None
 1.30A 5iktB-6barA:
undetectable		 5iktB-6barA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 12 LEU A 181
LEU A 327
GLY A 155
ALA A 156
LEU A 148
 None
 1.10A 5iktB-6barA:
undetectable		 5iktB-6barA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 12 VAL A 188
PHE A 309
PHE A 161
VAL A 144
VAL A 313
 None
 1.28A 5tudD-6barA:
undetectable		 5tudD-6barA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		4 / 4 HIS A 176
VAL A 163
LEU A 177
ALA A 137
 None
 1.23A 6d8pB-6barA:
undetectable		 6d8pB-6barA:
undetectable