SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bbj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		5 / 12 LEU A 191
GLY A 200
GLY A 201
ALA A 194
LEU A 195
 None
 0.97A 1bx4A-6bbjA:
undetectable		 1bx4A-6bbjA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		5 / 11 LEU A 209
ALA A 213
LEU A 169
LEU A 166
VAL A 154
 None
 1.07A 1ictA-6bbjA:
undetectable
1ictC-6bbjA:
undetectable		 1ictA-6bbjA:
21.54
1ictC-6bbjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		4 / 6 TYR A 617
VAL A 554
ILE A 558
LEU A 666
 None
 1.11A 1j96A-6bbjA:
undetectable		 1j96A-6bbjA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		3 / 3 ASP A 259
ASN A 224
THR A 192
 None
 0.74A 2pymB-6bbjA:
undetectable		 2pymB-6bbjA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		3 / 3 LYS A 193
ARG A 156
VAL A 154
 None
 0.90A 2r2vC-6bbjA:
undetectable
2r2vD-6bbjA:
undetectable		 2r2vC-6bbjA:
undetectable
2r2vD-6bbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLP_A_TESA1921_1
(ANDROGEN RECEPTOR)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		5 / 11 LEU A 695
LEU A 701
MET A 621
LEU A 669
THR A 673
 None
 1.42A 2ylpA-6bbjA:
undetectable		 2ylpA-6bbjA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		5 / 10 TYR A 342
ILE A 381
VAL A 325
VAL A 429
LEU A 388
 None
 1.28A 3elzC-6bbjA:
undetectable		 3elzC-6bbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		5 / 12 THR A 319
ASP A 314
ASN A 318
LEU A 324
SER A 357
 None
 1.30A 4pooA-6bbjA:
undetectable		 4pooA-6bbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		5 / 9 ILE A 541
GLY A 591
ASN A 537
LEU A 539
LEU A 594
 None
 1.47A 5fhzB-6bbjA:
undetectable		 5fhzB-6bbjA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		5 / 9 ALA A 262
ASP A 259
ILE A 223
ILE A 242
THR A 192
 None
 1.32A 5kr2C-6bbjA:
undetectable		 5kr2C-6bbjA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		3 / 3 TRP A 582
MET A 583
ASN A 584
 None
 1.01A 5uc1B-6bbjA:
undetectable		 5uc1B-6bbjA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		3 / 3 TRP A 582
MET A 583
ASN A 584
 None
 0.95A 5uc1A-6bbjA:
undetectable		 5uc1A-6bbjA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6bbj TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL, SUBFAMILY
V, MEMBER 4
(Xenopus
tropicalis) 		4 / 5 ILE A 451
LEU A 454
THR A 735
LEU A 738
 None
 0.87A 6nmpN-6bbjA:
undetectable
6nmpW-6bbjA:
undetectable		 6nmpN-6bbjA:
undetectable
6nmpW-6bbjA:
undetectable