SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 6bc1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 28
(Homo
sapiens) 		4 / 5 TYR C1124
ILE C1061
LEU C1115
LEU C1108
 None
 1.17A 2zb7A-6bc1C:
undetectable		 2zb7A-6bc1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 6bc1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 28
(Homo
sapiens) 		4 / 6 LEU C1087
LEU C1080
LEU C1058
LEU C1117
 None
 0.96A 5gs4A-6bc1C:
undetectable		 5gs4A-6bc1C:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 6bc1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 28
(Homo
sapiens) 		3 / 3 LEU C1055
GLN C1052
LYS C1084
 None
 0.96A 6exiB-6bc1C:
undetectable		 6exiB-6bc1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 6bc1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 28
(Homo
sapiens) 		3 / 3 LEU C1055
GLN C1052
LYS C1084
 None
 0.99A 6exiA-6bc1C:
undetectable		 6exiA-6bc1C:
20.00