SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		5 / 12 LEU A  33
LEU A 266
VAL A  35
VAL A 259
LEU A  60
 None
 1.23A 1ie9A-6bc5A:
undetectable		 1ie9A-6bc5A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		3 / 3 LEU A  75
HIS A  44
ILE A 175
 None
COA  A 301 (-3.8A)
None
 0.63A 1s9pB-6bc5A:
undetectable		 1s9pB-6bc5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		5 / 12 VAL A 185
ALA A 166
LEU A 169
VAL A 194
ALA A 193
 None
 1.14A 1sa1A-6bc5A:
undetectable
1sa1B-6bc5A:
undetectable		 1sa1A-6bc5A:
11.92
1sa1B-6bc5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		5 / 12 VAL A 185
ALA A 166
LEU A 169
VAL A 194
ALA A 193
 None
 1.11A 1sa1C-6bc5A:
undetectable
1sa1D-6bc5A:
undetectable		 1sa1C-6bc5A:
11.92
1sa1D-6bc5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		4 / 7 ALA A 158
ASP A 136
MET A 207
TYR A 205
 None
 1.38A 2pncA-6bc5A:
undetectable		 2pncA-6bc5A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		4 / 7 ALA A 158
TYR A 159
TYR A 205
HIS A 134
 None
 1.35A 2pncA-6bc5A:
undetectable		 2pncA-6bc5A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		4 / 6 ALA A 158
ASP A 136
MET A 207
TYR A 205
 None
 1.39A 2pncB-6bc5A:
undetectable		 2pncB-6bc5A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		4 / 7 TYR A 190
VAL A 254
ILE A 175
ARG A 251
 None
 1.17A 3ik3A-6bc5A:
undetectable		 3ik3A-6bc5A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		4 / 7 TYR A 190
VAL A 254
ILE A 175
ARG A 251
 None
 1.19A 3ik3B-6bc5A:
undetectable		 3ik3B-6bc5A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		5 / 12 LEU A  26
ALA A 118
GLY A 179
ALA A 262
SER A 264
 None
COA  A 301 (-3.3A)
None
None
None
 1.06A 3ln1A-6bc5A:
undetectable		 3ln1A-6bc5A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		5 / 12 LEU A  26
ALA A 118
GLY A 179
ALA A 262
SER A 264
 None
COA  A 301 (-3.3A)
None
None
None
 1.05A 3ln1B-6bc5A:
undetectable		 3ln1B-6bc5A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		5 / 12 LEU A  26
ALA A 118
GLY A 179
ALA A 262
SER A 264
 None
COA  A 301 (-3.3A)
None
None
None
 1.04A 3ln1C-6bc5A:
undetectable		 3ln1C-6bc5A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		5 / 10 GLY A 179
ALA A 180
ASP A 183
GLY A 117
ILE A 119
 None
COA  A 301 ( 3.9A)
COA  A 301 ( 4.7A)
COA  A 301 (-3.2A)
None
 0.88A 3ttpA-6bc5A:
undetectable		 3ttpA-6bc5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		5 / 10 GLY A 179
ALA A 180
ASP A 183
GLY A 117
ILE A 119
 None
COA  A 301 ( 3.9A)
COA  A 301 ( 4.7A)
COA  A 301 (-3.2A)
None
 0.92A 3ttpB-6bc5A:
undetectable		 3ttpB-6bc5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		4 / 7 GLU A 192
ASP A 230
ALA A 233
TYR A 232
 None
 1.19A 4zz8A-6bc5A:
undetectable		 4zz8A-6bc5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		4 / 7 GLY A 179
ALA A 180
GLY A 117
ILE A 119
 None
COA  A 301 ( 3.9A)
COA  A 301 (-3.2A)
None
 0.60A 5kqyB-6bc5A:
undetectable		 5kqyB-6bc5A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		3 / 3 SER A  24
LYS A  23
SER A  22
 None
 0.79A 6az3P-6bc5A:
undetectable		 6az3P-6bc5A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6bc5 AAC 3-VI PROTEIN
(Enterobacter
cloacae) 		4 / 7 ALA A 195
ASP A 247
ILE A 244
ILE A 272
 None
 0.93A 6fbnA-6bc5A:
undetectable		 6fbnA-6bc5A:
undetectable