SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bcq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 5 TRP B 681
VAL B 776
THR B 777
ILE B 708
 None
 1.30A 1ss4A-6bcqB:
undetectable		 1ss4A-6bcqB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 4 LEU B 510
PRO B 501
ILE B 474
LEU B 477
 None
 1.08A 1ya4B-6bcqB:
1.3		 1ya4B-6bcqB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 4 LEU B 510
PRO B 501
ILE B 474
LEU B 477
 None
 0.99A 1ya4C-6bcqB:
undetectable		 1ya4C-6bcqB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		3 / 3 TRP B 153
THR B 108
TYR B 104
 None
 1.25A 2a3bA-6bcqB:
2.1		 2a3bA-6bcqB:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 6 LEU B 569
LEU B 568
LEU B 477
LEU B 478
 None
 1.03A 2ab2A-6bcqB:
undetectable		 2ab2A-6bcqB:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 5 LEU B 569
LEU B 568
LEU B 477
LEU B 478
 None
 1.01A 2ab2B-6bcqB:
undetectable		 2ab2B-6bcqB:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 5 LEU B 395
ASP B 396
GLY B 387
ALA B 391
 None
 0.90A 2aohA-6bcqB:
undetectable		 2aohA-6bcqB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		5 / 11 GLY B 151
SER B 149
ALA B 381
THR B 363
VAL B 120
 None
 1.14A 2nnhA-6bcqB:
undetectable		 2nnhA-6bcqB:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 8 PHE B 779
ILE B 905
PHE B1065
TRP B 680
 None
 0.97A 2qwxA-6bcqB:
2.3
2qwxB-6bcqB:
3.4		 2qwxA-6bcqB:
13.85
2qwxB-6bcqB:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 5 ASP B 280
ILE B 289
ILE B 279
GLY B 306
 None
 0.95A 3bufA-6bcqB:
undetectable		 3bufA-6bcqB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		3 / 3 VAL B 672
VAL B 586
SER B 623
 None
 0.57A 3n8xB-6bcqB:
undetectable		 3n8xB-6bcqB:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		3 / 3 ARG B 251
MET B 285
ARG B 288
 None
 1.34A 3uvvA-6bcqB:
undetectable		 3uvvA-6bcqB:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 6 PHE B 619
ALA B 592
ALA B 566
LEU B 563
 None
 1.10A 4dtzB-6bcqB:
undetectable		 4dtzB-6bcqB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 5 ARG B 644
VAL B 586
LEU B 590
SER B 588
 None
 1.31A 4e1gA-6bcqB:
undetectable		 4e1gA-6bcqB:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		5 / 12 GLU B 620
ARG B 597
ALA B 592
GLY B 591
LEU B 595
 None
 1.36A 4oadA-6bcqB:
undetectable		 4oadA-6bcqB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 6 ILE B 958
ARG B 953
GLY B1005
VAL B1008
 None
 0.90A 4oltB-6bcqB:
1.9		 4oltB-6bcqB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 8 PHE B 779
ILE B 905
PHE B1065
TRP B 680
 None
 0.97A 4qogA-6bcqB:
2.9
4qogB-6bcqB:
3.4		 4qogA-6bcqB:
13.85
4qogB-6bcqB:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 6 TRP B 680
PHE B 779
ILE B 905
PHE B1065
 None
 1.09A 4qogA-6bcqB:
3.4
4qogB-6bcqB:
3.4		 4qogA-6bcqB:
13.85
4qogB-6bcqB:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		5 / 9 VAL B 586
LEU B 626
SER B 623
LEU B 590
LEU B 642
 None
 0.98A 4rs0A-6bcqB:
2.5		 4rs0A-6bcqB:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		3 / 3 GLU B 824
ILE B 897
ALA B 817
 None
 0.49A 4wnwB-6bcqB:
undetectable		 4wnwB-6bcqB:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		5 / 12 ILE B 690
VAL B 776
LEU B 780
LEU B 694
ALA B 696
 None
 1.09A 6ajiA-6bcqB:
undetectable		 6ajiA-6bcqB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 6 PHE B 441
ARG B 443
LEU B 444
ALA B 410
 None
 0.95A 6b89B-6bcqB:
undetectable		 6b89B-6bcqB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 7 PHE B 441
ARG B 443
LEU B 444
ALA B 410
 None
 0.88A 6b89A-6bcqB:
1.7		 6b89A-6bcqB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		4 / 6 GLY B 142
ASP B 137
ARG B 145
ARG B 140
 None
 1.13A 6dwdA-6bcqB:
undetectable
6dwdC-6bcqB:
undetectable		 6dwdA-6bcqB:
undetectable
6dwdC-6bcqB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Mus
musculus) 		5 / 11 MET B 431
LEU B 434
GLY B 582
PRO B 458
LEU B 464
 None
 1.47A 6euqA-6bcqB:
3.3		 6euqA-6bcqB:
undetectable