SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		 6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE
(Kordia
algicida) 		5 / 9 LEU A  31
SER A  33
TYR A  37
GLU A  47
LEU A  51
 None
 1.11A 1karA-6bdeA:
undetectable
1karB-6bdeA:
undetectable		 1karA-6bdeA:
11.74
1karB-6bdeA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE
(Kordia
algicida) 		5 / 9 GLU A  47
LEU A  51
LEU A  31
SER A  33
TYR A  37
 None
 1.05A 1karA-6bdeA:
undetectable
1karB-6bdeA:
undetectable		 1karA-6bdeA:
11.74
1karB-6bdeA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE
(Kordia
algicida) 		4 / 7 ILE A   5
GLY A  71
TYR A 133
LEU A  52
 HEM  A 201 (-4.6A)
None
HEM  A 201 (-4.5A)
None
 0.81A 3elzA-6bdeA:
undetectable		 3elzA-6bdeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE
(Kordia
algicida) 		4 / 8 PHE A   9
TYR A  70
LEU A  52
PHE A  45
 None
 1.15A 3rqwC-6bdeA:
undetectable
3rqwD-6bdeA:
undetectable		 3rqwC-6bdeA:
undetectable
3rqwD-6bdeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE
(Kordia
algicida) 		4 / 8 LEU A  52
PHE A  45
PHE A   9
TYR A  70
 None
 1.15A 3rqwF-6bdeA:
undetectable
3rqwJ-6bdeA:
undetectable		 3rqwF-6bdeA:
undetectable
3rqwJ-6bdeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE
(Kordia
algicida) 		5 / 12 GLY A 145
ASN A 148
ALA A 158
SER A  98
ILE A  99
 None
None
None
None
HEM  A 201 (-4.5A)
 1.10A 5ih0A-6bdeA:
undetectable		 5ih0A-6bdeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE
(Kordia
algicida) 		6 / 12 LEU A  86
ILE A  78
LEU A 116
VAL A 107
ILE A 103
LEU A  67
 None
HEM  A 201 (-3.6A)
HEM  A 201 (-4.9A)
HEM  A 201 (-4.3A)
HEM  A 201 (-4.2A)
None
 1.44A 5ycnA-6bdeA:
undetectable		 5ycnA-6bdeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE
(Kordia
algicida) 		5 / 12 ILE A 132
MET A 147
LEU A 162
LYS A 164
THR A 130
 None
HEM  A 201 (-4.3A)
None
None
None
 1.19A 5z6fA-6bdeA:
undetectable		 5z6fA-6bdeA:
undetectable